Gold Nanoparticles (AuNPs) as Reactive Matrix for Detection of Trace Levels of HCN in Air by Laser Desorption/Ionization Mass Spectrometry (LDI-MS)

Giving Gold Wings: Ultrabright and Fragmentation Free Mass Spectrometry Reporters for Barcoding, Bioconjugation Monitoring, and Data Storage

“…To examine the relative ion yields, we compared the best performing thiol monolayer, 12-AuNP, to the standard NHC system, 4-AuNP, by recording LDI-MS as a function of surface coverage. These data were analyzed by normalizing the peak area of the [(4) 2 Au] + and [( 12)Au] + ions to the Au 3 + gold cluster peak area, based on the method of Pavlov and Attygalle, [21] and plotting the normalized data versus the estimated surface coverage (Figure 5 and S9). This normalized data illustrates that the NHC ion signal surpasses the thiol ion signals at all surface coverages studied and at full surface coverage the NHC-tagged particles are two orders of magnitude brighter than the best thiol system studied here.…”