Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection

Review—Recent Advances in FSCV Detection of Neurochemicals via Waveform and Carbon Microelectrode Modification

“…Other coatings such as gold nanoparticles, have also enhanced the sensitivity and temporal resolution by increasing the conductivity and electroactive surface area of the carbon electrode substrate. 64 As gold microelectrodes have been used to detect many NTs and are comparable to CFMEs, 65 electrodeposition of Au nanoparticles (NP) was considered.…”

“…Energy-dispersive X-ray spectroscopy (EDS/EDX) measurements detailed a heterogeneous carbongold surface that increased sensitivity and provided for faster electron transfer kinetics. 64 Dopamine metabolites.-Other catecholamines that have been detected using FSCV are metabolites of DA. DOPAL (3,4-Dihydroxyphenylacetaldehyde) is metabolized by monoamine oxidase or MAO and is an aldehyde product of DA.…”

Timed Electrodeposition of PEDOT:Nafion onto Carbon Fiber-Microelectrodes Enhances Dopamine Detection in Zebrafish Retina

“…17,21 Recordings with CFMEs have been utilized over the past several decades as the standard for detection of neurotransmitters such as DA 15,22 because of their high sensitivity, high spatiotemporal resolution, low cost, and ease of operation. 23 Novel materials, such as epoxy coated electrodes, 24,25 carbon nanospikes grown onto metal wires, 26 carbon nanotube fibers, 27,28 and carbon nanotube yarns, [29][30][31] and other materials 32 have been used to enhance CFMEs with increased chemical sensitivities. Thus, FSCV utilizing CFMEs provides enhanced selectivity and temporal resolution than conventional slow scan CV, allowing for the measurement of neurotransmitter release on a subsecond timescale.…”