Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)

Dong, Jianyu; Zhao, Qinghao; Ying, Ying; Zhang, Lijie; Zou, Junrong; Zhao, Shuqi; Wang, J.; Jiang, Shanshan

doi:10.3892/mmr.2020.11580

Cited by 24 publications

(10 citation statements)

References 97 publications

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“…To form novel NDC-1 and NDC-2 drug conjugate gold nanoparticles, thiol-Au covalent bonds were used and then their solubility, stability, and anti-cancer efficacy were evaluated. Previously, AuNPs have been effectively used for drug dispersity in the literature. − Zhang et al attached Paclitaxel to AuNPs via DNA linkers for increased solubility and effectiveness . In another study, Paclitaxel was attached to AuNPs through thiol-terminated polyethylene glycol molecules and enhanced performance was obtained due to higher solubility and stability .…”

Section: Resultsmentioning

confidence: 99%

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

et al. 2023

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Ovarian cancer, which is one of the most diagnosed cancer types among women, maintains its significance as a global health problem. Several drug candidates have been investigated for the potential treatment of ovarian cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) demonstrated anti-cancer activity through the inhibition of cyclooxygenase 2 (COX-2) and by inhibiting COX-2-dependent prostaglandin (PG) production. Naproxen is one of the most used NSAIDs and Naproxen-derived compounds (NDCs) may show potential treatment effects on cancer as chemotherapeutic drugs. Although there are successful drug development studies, the lack of solubility of these drug candidates in aqueous media results in limited bioavailability and high variability of patient responses during treatment. Low aqueous solubility is one of the main problems in the pharmaceutical industry in terms of drug development. Nanotechnology-based strategies provide solutions to hydrophobic drug limitations by increasing dispersion and improving internalization. In this study, two different NDCs (NDC-1 and NDC-2) bearing a thiosemicarbazide/1,2,4-triazole moiety were synthesized and tested for chemotherapeutic effects on ovarian cancer cells, which have a high COX-2 expression. To overcome the limited dispersion of these hydrophobic drugs, the drug molecules were conjugated to the surface of 13 nm AuNPs. Conjugation of drugs to AuNPs increased the distribution of drugs in aqueous media, and NDC@AuNP conjugates exhibited excellent colloidal stability for up to 8 weeks. The proposed system demonstrated an increased chemotherapeutic effect than the free drug counterparts with at least 5 times lower IC50 values. NDC@AuNP nanosystems induced higher apoptosis rates, which established a simple and novel way to investigate activity of prospective drugs in drug discovery research.

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Section: Resultsmentioning

confidence: 99%

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

et al. 2023

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“…Considering that the molecular targets of Cu@Fe NPs do not overlap with those of conventional antibiotics, based on the properties of NPs, if antibiotics are adsorbed on the surface of nanocarriers, the synergistic effect of both nanoparticles can improve the ability of loaded drugs to pass through cell membranes and the uptake of antibiotics, which ultimately leads to an increase in antibacterial activity ( Azzopardi et al, 2013 ; Wong et al, 2013 ; Jelinkova et al, 2019 ). It has been reported that NPs as drug carriers can effectively load the first-line chemotherapeutic drug paclitaxel and improve the chemotherapeutic efficacy of paclitaxel in the treatment of cancers such as ovarian cancer ( Wang et al, 2020 ; Wu et al, 2021 ). Therefore, Cu@Fe NPs in combination with antibiotic therapy is also a new avenue to be considered, which awaits further investigation.…”

Section: Discussionmentioning

confidence: 99%

Novel copper-containing ferrite nanoparticles exert lethality to MRSA by disrupting MRSA cell membrane permeability, depleting intracellular iron ions, and upregulating ROS levels

Hou²,

Chen³

et al. 2023

Front. Microbiol.

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ObjectiveThe widespread use of antibiotics has inevitably led to the emergence of multidrug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA), making treatment of this infection a serious challenge. This study aimed to explore new treatment strategies for MRSA infection.MethodsThe structure of Fe3O4 NPs with limited antibacterial activity was optimized, and the Fe2+ ↔ Fe3+ electronic coupling was eliminated by replacing 1/2 Fe2+ with Cu2+. A new type of copper-containing ferrite nanoparticles (hereinafter referred to as Cu@Fe NPs) that fully retained oxidation–reduction activity was synthesized. First, the ultrastructure of Cu@Fe NPs was examined. Then, antibacterial activity was determined by testing the minimum inhibitory concentration (MIC) and safety for use as an antibiotic agent. Next, the mechanisms underlying the antibacterial effects of Cu@Fe NPs were investigated. Finally, mice models of systemic and localized MRSA infections was established for in vivo validation.ResultsIt was found that Cu@Fe NPs exhibited excellent antibacterial activity against MRSA with MIC of 1 μg/mL. It effectively inhibited the development of MRSA resistance and disrupted the bacterial biofilms. More importantly, the cell membranes of MRSA exposed to Cu@Fe NPs underwent significant rupture and leakage of the cell contents. Cu@Fe NPs also significantly reduced the iron ions required for bacterial growth and contributed to excessive intracellular accumulation of exogenous reactive oxygen species (ROS). Therefore, these findings may important for its antibacterial effect. Furthermore, Cu@Fe NPs treatment led to a significant reduction in colony forming units within intra-abdominal organs, such as the liver, spleen, kidney, and lung, in mice with systemic MRSA infection, but not for damaged skin in those with localized MRSA infection.ConclusionThe synthesized nanoparticles has an excellent drug safety profile, confers high resistant to MRSA, and can effectively inhibit the progression of drug resistance. It also has the potential to exert anti-MRSA infection effects systemically in vivo. In addition, our study revealed a unique multifaceted antibacterial mode of Cu@Fe NPs: (1) an increase in cell membrane permeability, (2) depletion of Fe ions in cells, (3) generation of ROS in cells. Overall, Cu@Fe NPs may be potential therapeutic agents for MRSA infections.

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“…In addition, spherical Au nanoparticles have been attracting considerable interest as non-toxic drug carrier systems for cancer treatment, thanks to the large surface-to-volume ratio; easy tuning of surface charge, hydrophilicity, and functionality; and outstanding stability [ 37 , 38 , 39 ]. Various biocompatible polymers (e.g., polyethylene glycol (PEG) [ 40 ], polyelectrolyte [ 37 ], DNA [ 25 ], liposome [ 41 ], and other bio-macromolecules [ 42 ]) can be used to tune the tumor microenvironment [ 43 ] and, more importantly, enhance the stability, payload capacity, and the cellular uptake.…”

Section: Gold Nanostructures For Cancer Treatmentmentioning

confidence: 99%

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters

Wang¹,

Shen

et al. 2022

Nanomaterials

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Cancer is a major global health issue and is a leading cause of mortality. It has been documented that various conventional treatments can be enhanced by incorporation with nanomaterials. Thanks to their rich optical properties, excellent biocompatibility, and tunable chemical reactivities, gold nanostructures have been gaining more and more research attention for cancer treatment in recent decades. In this review, we first summarize the recent progress in employing three typical gold nanostructures, namely spherical Au nanoparticles, Au nanorods, and atomically precise Au nanoclusters, for cancer diagnostics and therapeutics. Following that, the challenges and the future perspectives of this field are discussed. Finally, a brief conclusion is summarized at the end.

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Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)

Cited by 24 publications

References 97 publications

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Novel copper-containing ferrite nanoparticles exert lethality to MRSA by disrupting MRSA cell membrane permeability, depleting intracellular iron ions, and upregulating ROS levels

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters

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