Gold‐Nanoparticle‐Decorated Metal‐Organic Frameworks for Anticancer Therapy

Dhakshinamoorthy, Amarajothi; Navalón, Sergio; Asiri, Abdullah M.; Garcı́a, Hermenegildo

doi:10.1002/cmdc.202000562

Cited by 12 publications

(4 citation statements)

References 125 publications

(208 reference statements)

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“…In this regard, it causes highly toxic ROS species that modulate TME and eventually kill the cancer cell mass. Due to this mechanism, the presence of molecules such as O 2 can significantly increase the ability of nanoparticles to produce ROS, including 1 O 2; it also prevents the PDT from being endangered due to the hypoxic state of TME ( Dhakshinamoorthy et al, 2020 ; Yang et al, 2021 ).…”

Section: Metal Nanoparticles For Tme Modulationmentioning

confidence: 99%

Metallic Nanoparticles for the Modulation of Tumor Microenvironment; A New Horizon

Shariatzadeh

Moghimi

Khalafi

et al. 2022

Front. Bioeng. Biotechnol.

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Cancer is one of the most critical human challenges which endangers many people’s lives every year with enormous direct and indirect costs worldwide. Unfortunately, despite many advanced treatments used in cancer clinics today, the treatments are deficiently encumbered with many side effects often encountered by clinicians while deploying general methods such as chemotherapy, radiotherapy, surgery, or a combination thereof. Due to their low clinical efficacy, numerous side effects, higher economic costs, and relatively poor acceptance by patients, researchers are striving to find better alternatives for treating this life-threatening complication. As a result, Metal nanoparticles (Metal NPs) have been developed for nearly 2 decades due to their important therapeutic properties. Nanoparticles are quite close in size to biological molecules and can easily penetrate into the cell, so one of the goals of nanotechnology is to mount molecules and drugs on nanoparticles and transfer them to the cell. These NPs are effective as multifunctional nanoplatforms for cancer treatment. They have an advantage over routine drugs in delivering anticancer drugs to a specific location. However, targeting cancer sites while performing anti-cancer treatment can be effective in improving the disease and reducing its complications. Among these, the usage of these nanoparticles (NPs) in photodynamic therapy and sonodynamic therapy are notable. Herein, this review is aimed at investigating the effect and appliances of Metal NPs in the modulation tumor microenvironment which bodes well for the utilization of vast and emerging nanomaterial resources.

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Section: Metal Nanoparticles For Tme Modulationmentioning

confidence: 99%

Metallic Nanoparticles for the Modulation of Tumor Microenvironment; A New Horizon

Shariatzadeh

Moghimi

Khalafi

et al. 2022

Front. Bioeng. Biotechnol.

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“…Integrated systems with gold nanoparticles and porphyrin NMOF show tremendous promise in the theranostic field. The fabrication of low-cost materials within a single high-efficiency theranostic platform remains, however, a challenge [ 103 ]. The PDT oxygen dependency makes it less efficient under hypoxic conditions on solid tumours, and the generation of ROS has a narrow effective function range.…”

Section: Porphyrin Mofs As Theranostic Agentsmentioning

confidence: 99%

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

2022

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Metal-Organic Frameworks (MOFs) are hybrid multifunctional platforms that have found remarkable applications in cancer treatment and diagnostics. Independently, these materials can be employed in cancer treatment as intelligent drug carriers in chemotherapy, photothermal therapy, and photodynamic therapy; conversely, MOFs can further be used as diagnostic tools in fluorescence imaging, magnetic resonance imaging, computed tomography imaging, and photoacoustic imaging. One essential property of these materials is their great ability to fine-tune their composition toward a specific application by way of a judicious choice of the starting building materials (metal nodes and organic ligands). Moreover, many advancements were made concerning the preparation of these materials, including the ability to downsize the crystallites yielding nanoporous porphyrin MOFs (NMOFs) which are of great interest for clinical treatment and diagnostic theranostic tools. The usage of porphyrins as ligands allows a high degree of multifunctionality. Historically these molecules are well known for their reactive oxygen species formation and strong fluorescence characteristics, and both have proved helpful in cancer treatment and diagnostic tools. The anticipation that porphyrins in MOFs could prompt the resulting materials to multifunctional theranostic platforms is a reality nowadays with a series of remarkable and ground-breaking reports available in the literature. This is particularly remarkable in the last five years, when the scientific community witnessed rapid development in porphyrin MOFs theranostic agents through the development of imaging technologies and treatment strategies for cancer. This manuscript reviews the most relevant recent results and achievements in this particular area of interest in MOF chemistry and application.

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“…Metal nanoparticles, especially gold nanoparticles, have shown miracles in the field of nanoscience with their unique attributes like good biocompatibility, large surface-to-volume ratio, optoelectronic properties, low toxicity, etc., which make these important for an enormous range of applications such as imaging, catalysis, sensing, and therapeutics. − However, the high surface energy for small particles often leads to their aggregation under reaction conditions to form larger particles, leading to a decrease in the number of active sites, which affects their catalytic performance . This disadvantage can be overcome by protecting NPs using surface-capping agents. , However, these protecting ligands are found to be having adverse effects on the catalytic activity of NPs because of their strong chemical interaction with metal atoms.…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Gold Nanoparticles on Postsynthetically Modified NU-1000 for Hydrogen Evolution Reaction

et al. 2023

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NU-1000, being a hydrothermally stable metal− organic framework (MOF), with structural robustness is viable for functionalization with various entities. A postsynthetic modification strategy called solvent-assisted ligand incorporation (SALI) is chosen for functionalizing NU-1000 with thiol moieties using 2mercaptobenzoic acid. In accordance with soft acid-soft base interactions, the thiol groups on NU-1000, as a scaffold, can immobilize the gold nanoparticles without much aggregation. The catalytically active gold sites on thiolated NU-1000 are utilized for hydrogen evolution reaction (HER). The catalyst delivered an overpotential of 101 mV at a current density of 10 mAcm −2 in 0.5 M H 2 SO 4 . The faster charge transfer kinetics determined from the Tafel slope of 44 mV/dec enhances the HER activity. The sustainable performance of the catalyst for 36 h proves its utility as a potential catalyst to produce neat hydrogen.

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Gold‐Nanoparticle‐Decorated Metal‐Organic Frameworks for Anticancer Therapy

Cited by 12 publications

References 125 publications

Metallic Nanoparticles for the Modulation of Tumor Microenvironment; A New Horizon

Metallic Nanoparticles for the Modulation of Tumor Microenvironment; A New Horizon

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

Immobilization of Gold Nanoparticles on Postsynthetically Modified NU-1000 for Hydrogen Evolution Reaction

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