Gold Nanomaterials for Imaging-Guided Near-Infrared in vivo Cancer Therapy

Abstract

In recent years, tremendous efforts have been devoted into the fields of valuable diagnosis and anticancer treatment, such as real-time imaging, photothermal, and photodynamic therapy, and drug delivery. As promising nanocarriers, gold nanomaterials have attracted widespread attention during the last two decades for cancer diagnosis and therapy due to their prominent properties. With the development of nanoscience and nanotechnology, the fascinating bio-applications of functionalized gold nanomaterials have been gradually developed from in vitro to in vivo. This mini-review emphasizes some recent advances of photothermal imaging (PTI), surface-enhanced Raman scattering (SERS) imaging, and photoacoustic imaging (PAI)-guided based on gold nanomaterials in vivo therapy in near infrared region (>800 nm). We focus on the fundamental strategies, characteristics of bio-imaging modalities involving the advantages of multiples imaging modalities for cancer treatment, and then highlight a few examples of each techniques. Finally, we discuss the perspectives and challenges in gold nanomaterial-based cancer therapy.

Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

“…Furthermore, other vital organs (heart, lung, liver, kidneys, pancreas) were also extracted. The MPA and QC quantification in various vital organs including tumors was measured in order to determine the body distribution of the MPA and QC (Dun et al, 2013b;Jain N. K. et al, 2013;Chaudhary et al, 2019;Tian et al, 2019).…”

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

“…On the basis of the photothermal effects from PTAs, PTI has emerged as a powerful imaging technology in cancer diagnosis and treatment. [249] PTI uses the speed of light deflection technology to monitor the temperature change of the sample due to local wavelength-dependent light absorption. [250] PTAs can serve as exogenous photothermal transduction agents for both PTT and PTI because they have desirable PCE in the visible to NIR region which enables them to absorb light energy, which can evoke a local hyperthermia by nonradiative conversion.…”

“…[250] PTAs can serve as exogenous photothermal transduction agents for both PTT and PTI because they have desirable PCE in the visible to NIR region which enables them to absorb light energy, which can evoke a local hyperthermia by nonradiative conversion. [249,251] Briefly, this technology has the following advantages: First, the imaging platform is easy to implement (mainly relying on the laser source and a portable infrared camera); second, it has a high signal-to-noise ratio. The PTI is obtained by the detection of temperature changes within the target tissues, which results in a Figure 14.…”

Recent Advances in the Use of Iron–Gold Hybrid Nanoparticles for Biomedical Applications

“…This property makes gold NPs an ideal choice as calorimetric sensors and nanoprobes for surface-enhanced Raman spectroscopy (SERS) and labels for imaging or photothermal agents for cancer therapy. Gold NPs can be easily functionalized using thiols and amines, while iron-oxide NPs can be functionalized using catechols, silanes, diol carboxylic groups, or amines [ 14 , 15 ].…”