Gold nanoclusters: synthetic strategies and recent advances in fluorescent sensing

Halawa, Mohamed Ibrahim; Lai, Jianping; Xu, Guobao

doi:10.1016/j.mtnano.2018.11.001

Cited by 77 publications

(34 citation statements)

References 141 publications

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“…164,172,173 Glutathione (GSH) is often used as a capping agent in a simple and eco-friendly synthesis process requiring no additional reducing agents, to produce biocompatible AuNCs with a relatively high quantum yield. 174,175 For use as delivery agents, inorganic NPs are often coated with polymers and conjugated to various ligands to enhance stability, biocompatibility, and transfection. As-synthesised capped AuNPs and AuNCs can easily bond with cationic polymers, such as chitosan and polyethyleneimine (PEI), facilitating interactions with anionic cell membrane components and anionic groups of other ligands.…”

Section: Gold Nanomaterialsmentioning

confidence: 99%

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Therapeutic applications of CRISPR/Cas9 in breast cancer and delivery potential of gold nanomaterials

Padayachee

Singh

2020

Nanobiomedicine

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Globally, approximately 1 in 4 cancers in women are diagnosed as breast cancer (BC). Despite significant advances in the diagnosis and therapy BCs, many patients develop metastases or relapses. Hence, novel therapeutic strategies are required, that can selectively and efficiently kill malignant cells. Direct targeting of the genetic and epigenetic aberrations that occur in BC development is a promising strategy to overcome the limitations of current therapies, which target the tumour phenotype. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system, composed of only an easily modifiable single guide RNA (sgRNA) sequence bound to a Cas9 nuclease, has revolutionised genome editing due to its simplicity and efficiency compared to earlier systems. CRISPR/Cas9 and its associated catalytically inactivated dCas9 variants facilitate the knockout of overexpressed genes, correction of mutations in inactivated genes, and reprogramming of the epigenetic landscape to impair BC growth. To achieve efficient genome editing in vivo, a vector is required to deliver the components to target cells. Gold nanomaterials, including gold nanoparticles and nanoclusters, display many advantageous characteristics that have facilitated their widespread use in theranostics, as delivery vehicles, and imaging and photothermal agents. This review highlights the therapeutic applications of CRISPR/Cas9 in treating BCs, and briefly describes gold nanomaterials and their potential in CRISPR/Cas9 delivery.

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Section: Gold Nanomaterialsmentioning

confidence: 99%

Section: Delivery Of Crispr/cas9mentioning

confidence: 99%

Therapeutic applications of CRISPR/Cas9 in breast cancer and delivery potential of gold nanomaterials

Padayachee

Singh

2020

Nanobiomedicine

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“…In recent years the metal NCs, consisting of several to several tens of metal atoms with a particle size of about 2 nm, have attracted wide attention of researchers because of its unique physical and chemical properties different from metal NPs . Especially, the metal NCs also present the enzyme‐like activity, such as Au NCs and starch‐supported Cu/Au nanoclusters . Because of its programmability and biocompatibility, DNA is often used as a ligand to synthesize nanoclusters to mimic enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

Using G‐Rich Sequence to Enhance the Peroxidase‐Mimicking Activity of DNA‐Cu/Ag Nanoclusters for Rapid Colorimetric Detection of Hydrogen Peroxide and Glucose

Wei

2020

ChemistrySelect

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Four kinds of DNA‐based Ag and Cu/Ag nanoclusters (NCs) were synthesized and their fluorescence properties were investigated at pH 7.0 and 5.5. Among them the Cu/Ag NCs templated by DNA containing both C‐rich and G‐rich sequences (the c‐myc TBA−Cu/Ag NCs) give the strongest and the most stable fluorescence emission at ∼555 nm under neutral and acidic conditions. Unexpectedly, the c‐myc TBA−Cu/Ag NCs can catalyze efficiently and rapidly the reaction of hydrogen peroxide (H2O2) with 3,3′,5,5′‐tetramethylbenzidine (TMB) to produce blue TMB oxide (TMBox) under acidic conditions, indicating the high peroxidase‐mimicking activity. Based on this nanozyme the detection for H2O2 and glucose was performed using colorimetric method. The results indicate that the linear range of detection for H2O2 is from 0.1 to 1 mM with the detection limit (LOD) of 7.42 μM, while the linear range is from 0.1 to 0.7 mM and LOD was calculated to be 9.38 μM for glucose. Additionally, glucose can be successfully detected in diluted serum samples and has an acceptable recovery rate, indicating that this nanozyme has a potential application prospect.

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“…AuNPr have been increasingly investigated as OCT contrast agents in recent years. Si et al synthesized AuNPr with high scattering cross-section and LSPR in the NIR-II window, and demonstrated that intravenous injection of AuNPr can dramatically enhance the contrast of OCT vascular imaging, Lithography with patterned photoresist posts as the template 16,162 Visible to NIR-I SERS 16 Nanocrescent Lithography with a nanosphere template and vapor-phase deposition 35,36 Visible to NIR-II SERS 36,120 Nanoclusters Alkanethiol/phosphine-stabilized reduction 163 Visible to NIR-I Fluorescence [142][143][144][145][146] especially for tumors (Fig. 5A-D).…”

Section: Optical Imaging Based On Lspr-enhanced Scatteringmentioning

confidence: 99%

Gold nanomaterials for optical biosensing and bioimaging

Razmi

Nur

et al. 2021

Nanoscale Adv.

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Gold nanoclusters: synthetic strategies and recent advances in fluorescent sensing

Cited by 77 publications

References 141 publications

Therapeutic applications of CRISPR/Cas9 in breast cancer and delivery potential of gold nanomaterials

Therapeutic applications of CRISPR/Cas9 in breast cancer and delivery potential of gold nanomaterials

Using G‐Rich Sequence to Enhance the Peroxidase‐Mimicking Activity of DNA‐Cu/Ag Nanoclusters for Rapid Colorimetric Detection of Hydrogen Peroxide and Glucose

Gold nanomaterials for optical biosensing and bioimaging

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