Gold nanoclusters conjugated berberine reduce inflammation and alleviate neuronal apoptosis by mediating M2 polarization for spinal cord injury repair

Zhou, Zipeng; Li, Dan; Fan, Xiangyi; Yuan, Yajiang; Wang, Hongyu; Wang, Dahao; Mei, Xifan

doi:10.1093/rb/rbab072

Cited by 16 publications

(9 citation statements)

References 43 publications

(36 reference statements)

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“…iNOS was a phenotypic marker of proinflammatory macrophages [ 38 ]. It was reported that local accumulation of proinflammatory iNOS + macrophages often represented the accelerated loss of graft [ 39 , 40 ]. Thus, reducing inflammatory response damage was also an important strategy to promote neural regeneration [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

Wang

Sun

et al. 2022

Regenerative Biomaterials

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Transplantation of adult spinal cord tissue (aSCT) is a promising treatment for spinal cord injury (SCI) basing on various types of neural cells and matrix components inside aSCT. However, long-term systemic administration of immunosuppressors (e.g. tacrolimus, TAC) is required for the survival of allogeneic tissue, which often associated with severe side effects such as infection, liver damage, and renal failure, etc. In this study, a triglycerol monostearate-based (TGM) TAC delivery system (e.g. TAC@TGM) with high drug loading concentration was developed, which possessed injectable properties as well as sustainable and immune-responsive drug release behaviors. In complete transected SCI model, locally injected TAC@TGM could reduce the infiltration of inflammation cells, enhance the survival of transplanted aSCT (e.g. Tuj-1+ and NF+ neurons), and promote the recovery of locomotor function. Moreover, controlled release of TAC by TAC@TGM attenuated side effects of TAC on liver and kidneys compared with traditional systemic administration. More importantly, the developed TAC@TGM system provided a facile single dose of long-term immunosuppressive effect not just for aSCT transplantation, but also for other tissue/organ and cell transplantations. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

Wang

Sun

et al. 2022

Regenerative Biomaterials

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“…Recently, Mei et al. [ 57 ] developed novel AuNCs conjugated to positively charged berberine through electrostatic interactions. One hundred 20-nm NPs stabilized by bovine serum albumin (BSA) showed effective anti-apoptotic ability and regulated M2 macrophage polarization.…”

Section: Functional Nanomaterials For Sci Treatmentmentioning

confidence: 99%

Recent advances in nanomaterials for the treatment of spinal cord injury

Gong

Zhang

Che

et al. 2023

Materials Today Bio

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“…‘Immune-interactive’ biomaterials can modulate such a balance and thereby direct the suitable immune response for tissue regeneration [ 444 , 445 ]. Some biomaterials that are capable of mediating macrophage polarization are particularly attractive for tissue regeneration [ 446 ]. Macrophages can polarize to pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype.…”

Section: Cell–biomaterials Interactionsmentioning

confidence: 99%

Recent advances in regenerative biomaterials

Cao

Ding

2022

Regenerative Biomaterials

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Nowadays, biomaterials have evolved from the inert supports or functional substitutes, to the bioactive materials able to trigger or promote the regenerative potential of tissues. The interdisciplinary progress has broadened the definition of “biomaterials”, and a typical new insight is the concept of tissue induction biomaterials. The term “regenerative biomaterials” and thus the contents of the present paper are relevant to yet beyond tissue induction biomaterials. This review summarizes the recent progress of medical materials including metals, ceramics, hydrogels, other polymers, and bio-derived materials. As the application aspects are concerned, this paper introduces regenerative biomaterials for bone and cartilage regeneration, cardiovascular repair, three dimensional bioprinting, wound healing, and medical cosmetology. Cell-biomaterial interactions are highlighted. Since the global pandemic of COVID-19, the review particularly mentions biomaterials for public health emergency. In the last section, perspectives are suggested: (1) Creation of new materials is the source of innovation; (2) Modification of existing materials is an effective strategy for performance improvement; (3) Biomaterial degradation and tissue regeneration are required to be harmonious with each other; (4) Host responses can significantly influence the clinical outcomes; (5) The long-term outcomes should be paid more attention to; (6) The non-invasive approaches for monitoring in vivo dynamic evolution are required to be developed; (7) Public health emergencies call for more research & development of biomaterials; (8) Clinical translation needs to be pushed forward in a full-chain way. In the future, more new insights are expected to be shed into the brilliant field — regenerative biomaterials.

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Gold nanoclusters conjugated berberine reduce inflammation and alleviate neuronal apoptosis by mediating M2 polarization for spinal cord injury repair

Cited by 16 publications

References 43 publications

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue

Recent advances in nanomaterials for the treatment of spinal cord injury

Recent advances in regenerative biomaterials

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