Gold nanocluster-based fluorescence turn-off probe for sensing of doxorubicin by photoinduced electron transfer

Huang, Kai-Yuan; He, Hong-Xing; He, Shao‐Bin; Zhang, Xiangping; Peng, Hua-Ping; Lin, Zhen; Deng, Hao‐Hua; Xia, Xing‐Hua; Chen, Wei

doi:10.1016/j.snb.2019.126656

Cited by 67 publications

(23 citation statements)

References 54 publications

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“…The fact that DOX contains a quinone group in its structure, which is a very efficient electron transfer quencher (note that AQS also contains this group), supports this hypothesis. In addition, other works have also reported that DOX is a potent electron acceptor involved in the quenching of fluorophores through the PET process [57][58][59]. Since this mechanism only operates over very short distances, this would indicate that the DOX molecules have to be sufficiently close to the HTMA-PFP backbone or in Van der Waals contact to induce the quenching.…”

Section: Fluorescent Nanogels As Drug Carriers and Image Probes Ability Of Blue-emitting Nps To Bind Doxmentioning

confidence: 97%

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Rubio-Camacho

Martínez-Tomé

Mira

et al. 2021

IJMS

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In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop fluorescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes.

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Section: Fluorescent Nanogels As Drug Carriers and Image Probes Ability Of Blue-emitting Nps To Bind Doxmentioning

confidence: 97%

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Rubio-Camacho

Martínez-Tomé

Mira

et al. 2021

IJMS

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“…In this respect, recent efforts have been made in developing glove-based electroanalytical devices. 3–5…”

Section: Introductionmentioning

confidence: 99%

A wearable screen-printed SERS array sensor on fire-retardant fibre gloves for on-site environmental emergency monitoring

et al. 2022

Anal. Methods

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“…In a typical PET process of AuNCs, relatively weak electron–hole coupling will suppress Auger-assisted electron transfer behavior and thereby give rise to a distinguished Marcus inverted region [ 28 , 29 , 30 , 31 ]. Moreover, the fluorescence of a AuNC-based PET probe is sensitive to the alteration of their physicochemical characteristics, for instance, the surface charge, redox state, metallic core size, and ligand length [ 32 , 33 , 34 , 35 ]. Inspired by these attractive properties mentioned above, herein, a new fluorometric AQ4N assay was rationally designed by triggering molecule-like PET behavior of AuNCs ( Scheme 1 ), in which the carboxylated chitosan (CC) and dithiothreitol (DTT) co-stabilized AuNCs (CC/DTT-AuNCs) served as an electron donor and AQ4N acted as an electron acceptor.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanocluster-Based Fluorometric Banoxantrone Assay Enabled by Photoinduced Electron Transfer

et al. 2022

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Monitoring the blood concentration of banoxantrone (AQ4N) is important to evaluate the therapeutic efficacy and side effects of this new anticancer prodrug during its clinical applications. Herein, we report a fluorescence method for AQ4N detection through the modulation of the molecule-like photoinduced electron transfer (PET) behavior of gold nanoclusters (AuNCs). AQ4N can electrostatically bind to the surface of carboxylated chitosan (CC) and dithiothreitol (DTT) co-stabilized AuNCs and quench their fluorescence via a Coulomb interaction-accelerated PET process. Under optimized experimental conditions, the linear range of AQ4N is from 25 to 200 nM and the limit of detection is as low as 5 nM. In addition, this assay is confirmed to be reliable based on its successful use in AQ4N determination in mouse plasma samples. This work offers an effective strategy for AQ4N sensing based on fluorescent AuNCs and widens the application of AuNCs in clinical diagnosis and pharmaceutical analysis.

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Gold nanocluster-based fluorescence turn-off probe for sensing of doxorubicin by photoinduced electron transfer

Cited by 67 publications

References 54 publications

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

A wearable screen-printed SERS array sensor on fire-retardant fibre gloves for on-site environmental emergency monitoring

Gold Nanocluster-Based Fluorometric Banoxantrone Assay Enabled by Photoinduced Electron Transfer

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