Gold Nanocages: Engineering Their Structure for Biomedical Applications

Chen, Jingyi; Li, Zhiyuan; Campbell, Dean J.; Saeki, Fusayo; Cang, Hu; Au, Leslie; Lee, Jennifer; Li, Xingde; Xia, Younan

doi:10.1002/chin.200545229

Cited by 65 publications

(92 citation statements)

References 1 publication

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“…Preferential heating of the tumour region can be enhanced by utilising light absorbing nanoparticles [9][10][11]. Nanoparticles of different material, size and shape have been used for this purpose; examples include gold nanoshells [10,11], gold nanorods (GNR) [12][13][14], carbon nanotubes [15,16] and gold nanocages [17,18]. Mainly, gold is the material of choice as it is biocompatible [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Role of optical coefficients and healthy tissue-sparing characteristics in gold nanorod-assisted thermal therapy

Soni

Tyagi

Taylor

et al. 2013

International Journal of Hyperthermia

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Section: Introductionmentioning

confidence: 99%

Role of optical coefficients and healthy tissue-sparing characteristics in gold nanorod-assisted thermal therapy

Soni

Tyagi

Taylor

et al. 2013

International Journal of Hyperthermia

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“…[42][43][44][45][46][47][48][49][50][51][52] For example, plasmonic noble metal nanoparticles, quantum dot (QD), carbon nanotubes and iron oxide nanoparticles have a passive-targeting ability. 13,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] Their small size enhances transmigration across the blood-brain barrier (BBB), which protects the brain from harmful substances but also prevents the e®ective delivery of contrast agents. 13 As a result, nanoparticles can accumulate in the vicinity of the brain vasculature and enhance optical contrast.…”

Section: Contrast Agents: Peg-gnrsmentioning

confidence: 99%

Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

Zhang

Rong

et al. 2019

J. Innov. Opt. Health Sci.

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In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

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“…Gold nanoparticles (Au NPs) are characterized by plasmonic optical properties [1][2][3], which can be manipulated by changing their geometry [4]. Therefore, literature describes Au NPs having shapes such as: spherical, nanorods [5], nanoprisms [6,7], nanoshells [8] and nanocages [9], leading to different optical properties. The possibility to change the absorption spectral range by Au NPs made these nanoparticles find potential applications in optoelectronics [10], photonics [11], spectroscopy [12,13] as well as biomedical fields, especially in photothermal anticancer therapy (PTT), where Au NPs are used as photosensitizers [14].…”

Section: Introductionmentioning

confidence: 99%

Temperature-controlled synthesis of hollow, porous gold nanoparticles with wide range light absorption

et al. 2020

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An easy synthesis method of hollow, porous gold nanoparticles (AuHP NPs) with controlled diameter and pores sizes and with a wide range of light absorbance (continuous between 500 and 900 nm) is presented together with the explanation of the nanoparticle formation mechanism. The NPs were investigated using transmission electron microscopy (TEM) combined with the selected area electron diffraction patterns, X-ray diffraction and ultraviolet-visible spectroscopy. TEM images showed that changing the synthesis temperature allows to obtain AuHP NPs with sizes from 35 ± 4 nm at 60°C to 76 ± 8 nm at 90°C. The effects of nanoscale porosity on the far-and near-field optical properties of the nanoparticles, as well as on effective conversion of electromagnetic energy into thermal energy, were applied in simulated photothermal cancer therapy. The latter one was simulated by irradiation of two cancer cell lines SW480 and SW620 with lasers operating at 650 nm and 808 nm wavelengths. The mortality of cells after using the synthesized AuHP NPs as photosensitizers is between 20 and 50% and increases with the decrease in the diameter of the AuHP NPs. All these attractive properties of the AuHP NPs make them find application in many biomedical studies.

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Gold Nanocages: Engineering Their Structure for Biomedical Applications

Cited by 65 publications

References 1 publication

Role of optical coefficients and healthy tissue-sparing characteristics in gold nanorod-assisted thermal therapy

Role of optical coefficients and healthy tissue-sparing characteristics in gold nanorod-assisted thermal therapy

Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

Temperature-controlled synthesis of hollow, porous gold nanoparticles with wide range light absorption

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