Gold-Immobilized Photonic Crystal Fiber-Based SPR Biosensor for Detection of Malaria Disease in Human Body

Chaudhary, Vijay Shanker; Kumar, Dharmendra; Kumar, Santosh

doi:10.1109/jsen.2021.3085829

Cited by 127 publications

(31 citation statements)

References 35 publications

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“…Quite recently, Chaudhary et al joined the technology of photonic crystals and SPR to develop a gold-immobilized photonic crystal fiber-based SPR biosensor for malaria detection [ 68 ]. This system measures changes in the RBCs refractive index, not specifically hemozoin [ 68 ].…”

Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

Review of Microdevices for Hemozoin-Based Malaria Detection

et al. 2022

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Despite being preventable and treatable, malaria still puts almost half of the world’s population at risk. Thus, prompt, accurate and sensitive malaria diagnosis is crucial for disease control and elimination. Optical microscopy and immuno-rapid tests are the standard malaria diagnostic methods in the field. However, these are time-consuming and fail to detect low-level parasitemia. Biosensors and lab-on-a-chip devices, as reported to different applications, usually offer high sensitivity, specificity, and ease of use at the point of care. Thus, these can be explored as an alternative for malaria diagnosis. Alongside malaria infection inside the human red blood cells, parasites consume host hemoglobin generating the hemozoin crystal as a by-product. Hemozoin is produced in all parasite species either in symptomatic and asymptomatic individuals. Furthermore, hemozoin crystals are produced as the parasites invade the red blood cells and their content relates to disease progression. Hemozoin is, therefore, a unique indicator of infection, being used as a malaria biomarker. Herein, the so-far developed biosensors and lab-on-a-chip devices aiming for malaria detection by targeting hemozoin as a biomarker are reviewed and discussed to fulfil all the medical demands for malaria management towards elimination.

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Section: Biosensors For Hemozoin-based Malaria Diagnosismentioning

confidence: 99%

Review of Microdevices for Hemozoin-Based Malaria Detection

et al. 2022

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“…It contains a periodic structure in the cladding (air holes) instead of core and cladding or a similar defect in the core to obtain a performance different than that of traditional fibers. Several MOF-based biosensors have been reported in the past decades due to the availability of longitudinal pores that perform as tiny sample chambers and provide the effective RI for light confinement simultaneously [ 49 , 50 , 51 ]. The schematics of novel MOF-based biosensors can be seen Figure 4 .…”

Section: Fiber Optic Biosensorsmentioning

confidence: 99%

“…The pH measurement sensitivity was 1.21459 with good linearity of 0.97761. In addition to the above experimental demonstrations, several groups performed detailed numerical investigations for different novel sensing configurations, such as D-shaped photonic crystal fiber (PCF), mono-rectangular core PCF, twin-core PCF, etc., to enhance the sensitivity, improve the figure of merit, and provide the user-friendly interface [ 50 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Fiber Optic Biosensorsmentioning

confidence: 99%

Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review

et al. 2022

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The increasing use of nanomaterials and scalable, high-yield nanofabrication process are revolutionizing the development of novel biosensors. Over the past decades, researches on nanotechnology-mediated biosensing have been on the forefront due to their potential application in healthcare, pharmaceutical, cell diagnosis, drug delivery, and water and air quality monitoring. The advancement of nanoscale science relies on a better understanding of theory, manufacturing and fabrication practices, and the application specific methods. The topology and tunable properties of nanoparticles, a part of nanoscale science, can be changed by different manufacturing processes, which separate them from their bulk counterparts. In the recent past, different nanostructures, such as nanosphere, nanorods, nanofiber, core–shell nanoparticles, nanotubes, and thin films, have been exploited to enhance the detectability of labelled or label-free biological molecules with a high accuracy. Furthermore, these engineered-materials-associated transducing devices, e.g., optical waveguides and metasurface-based scattering media, widened the horizon of biosensors over a broad wavelength range from deep-ultraviolet to far-infrared. This review provides a comprehensive overview of the major scientific achievements in nano-biosensors based on optical fiber, nanomaterials and terahertz-domain metasurface-based refractometric, labelled and label-free nano-biosensors.

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“…The main features of the PCF-SPR sensor, WS, is measured by the wavelength interrogation method [36],…”

Section: Sensor Structure Design Fabrication Feasibility Analysis and Numerical Modelingmentioning

confidence: 99%

Designing Highly Sensitive Surface Plasmon Resonance Sensor With Dual Analyte Channels

et al. 2021

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The ease of controlling waveguide properties through unparalleled design flexibility has made the photonic crystal fiber (PCF) an attractive platform for plasmonic structures. In this work, a dual analyte channel's highly sensitive PCF bio-sensor is proposed based on surface plasmon resonance (SPR). In the proposed design, surface plasmons (SPs) are excited in the inner flat portion of two rectangular analyte channels where gold (Au) strip is deposited. Thus, the surface roughness that might be generated during metal deposition on circular surface could be effectively reduced. Considering the refractive index (RI) change in the analyte channels, the proposed sensor is designed and fully characterized by the finite element method based COMSOL Multiphysics software. Improved sensing characteristics including wavelength sensitivity (WS) of 186,000 nm/RIU and amplitude sensitivity (AS) of 2,792.97 RIU −1 in the wide RI range of 1.30 to 1.43 is obtained. In addition, the proposed sensor exhibits excellent resolution of 5.38 × 10 −7 , signal to noise ration (SNR) of 13.44 dB, figure of merits (FOM) of 2188.23, detection limit (DL) of 101.05 nm, and detection accuracy (DA) of 0.0204 nm −1 . Outcomes of the analysis indicate that the proposed sensor could be suited for accurate detection of organic chemicals, bio-molecules, and biological analytes.INDEX TERMS plasmonic, bio-sensor, photonic crystal fiber, finite element method, detection lmimit

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Gold-Immobilized Photonic Crystal Fiber-Based SPR Biosensor for Detection of Malaria Disease in Human Body

Cited by 127 publications

References 35 publications

Review of Microdevices for Hemozoin-Based Malaria Detection

Review of Microdevices for Hemozoin-Based Malaria Detection

Optical Fiber, Nanomaterial, and THz-Metasurface-Mediated Nano-Biosensors: A Review

Designing Highly Sensitive Surface Plasmon Resonance Sensor With Dual Analyte Channels

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