Gold determination in biological fluids by atomic absorption spectrophotometry: application to chrysotherapy in rheumatoid arthritis patients

Lorber, Arthur; Cohen, Richard L.; Chang, Chia Chin; Anderson, Harold E.

doi:10.1002/art.1780110207

Cited by 75 publications

(23 citation statements)

References 4 publications

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“…Thus the concentration of gamma globulin in normal synovial fluid is approximately 2.4 mg/ml (9) and the concentration of histidine in normal serum is about 0.1 mM (10-16). The concentration of gold in serum from patients being treated is about 30 pM (17)(18)(19)(20); in synovial fluid from one patient it was 10 pM (20). The concentration of nonceruloplasmin copper in normal synovial fluid is about 6 pM (21).…”

Section: Discussionmentioning

confidence: 99%

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Gerber

1974

Arthritis & Rheumatism

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Gold thiomalate (40 pM), penicillamine (40 pM), and histidine (20 pM) inhibit the copper-catalyzed (20 pM) thermal aggregation of human gamma globulin (0.8 mg/ml). At these concentrations, inhibition of gamma globulin aggregation was 87%, 96%, and 99% complete. This effect may be related to the reported suppressive effect of these agents in rheumatoid arthritis and adds support to the hypothesis that the hypohistidinemia of rheumatoid arthritis participates in the pathogenesis of the disease. Gold thiomalate (l), D-penicillamine (2),and L-histidine (3,4) have been reported to be effective in the treatment of rheumatoid arthritis. There is good evidence that aggregated gamma globulin is inflammatory, antigenic, and a stimulus to the formation of rheumatoid factors (5). There is also some evidence for the presence of aggregated gamma globulin in the synovial fluid of patients with rheumatoid arthritis (6,7).

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Section: Discussionmentioning

confidence: 99%

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Gerber

1974

Arthritis & Rheumatism

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“…The plasma, urine and supernatant from the fecal ashes were analyzed according to the method of internal standards, as described by Lorber et al (15). using a single slot burner and acetylene at 9 psi.…”

Section: Methodsmentioning

confidence: 99%

Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated

Mascarenhas¹,

Granda²,

Freyberg³

1972

Arthritis & Rheumatism

113

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Absorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Urinary excretion was greatest during the first day postinjection while fecal excretion was greatest during the middle of the week. The blood levels, as well as excretion, varied from patient to patient. Patients on maintenance therapy excreted 39,16,12 and 10% of the injected dose in the first, second, third and fourth weeks postinjection, respectively. There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity.Gold salts have been used for the treatment of rheumatoid arthritis for 40 years. Interest in this form of therapy was stimulated by Forestier (1) in 1929, who stated "the mode of action of aurotherapy in chronic rheumatism cannot

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“…The cells were then washed extensively and evaluated [2][3][4][5] ,ug/ml (37)(38)(39)(40)(41)(42), equivalent to 4-10 gg/ml of GST. Purified monocytes were suspended in medium containing 10% FBS (0.5 x 106/ml), and cultured in test tubes with or without GST.…”

mentioning

confidence: 99%

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

Lipsky¹,

Ziff²

1977

J. Clin. Invest.

186

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Gold determination in biological fluids by atomic absorption spectrophotometry: application to chrysotherapy in rheumatoid arthritis patients

Cited by 75 publications

References 4 publications

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Copper‐catalyzed thermal aggregation of human gamma‐globulin inhibition by histidine, gold thiomalate, and penicillamine

Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

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