Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery

Eskandari, Parvaneh; Bigdeli, Bahareh; Daryasari, Mohammad Porgham; Baharifar, Hadi; Bazri, Behrouz; Shourian, Mostafa; Amani, Amir; Sadighi, Armin; Goliaei, Bahram; Khoobi, Mehdi; Saboury, Ali Akbar

doi:10.1080/1061186x.2019.1599379

Cited by 44 publications

(17 citation statements)

References 41 publications

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“…A similar approach with the application of another MMP substrate, KDPLGVC peptide, was proposed by Eskandari et al [ 118 ]. The peptide was bound onto the surface of DOX–loaded MSN through amidation reaction, and then grafted with a gold nanoparticle–biotin conjugate (GNP) as end–capping and active targeting agent.…”

Section: Stimuli-responsive Drug Delivery Systemsmentioning

confidence: 99%

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

et al. 2021

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Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients’ recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery, simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010–2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.

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Section: Stimuli-responsive Drug Delivery Systemsmentioning

confidence: 99%

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

et al. 2021

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“…For example, one unique feature of the cancerous tissues is the overexpression of a type of extracellular proteolytic enzyme, called the matrix metalloproteinases (MMPs) [132]. Based on this feature, several MMP-responsive nanocarriers have been developed as one approach for the targeted cancer treatment [133]. For targeted anti-inflammatory treatment, a protease secreted by neutrophils, called human neutrophil elastase (HNE) is exploited as a biological cue for controlled drug release from nanocarriers equipped with HNE-sensitive peptide linkers [134,135].…”

Section: Enzyme-responsive Nanocarriersmentioning

confidence: 99%

“…With the rising awareness of assessing the safety profiles of newly developed nanocarriers, more and more investigators have started including in vivo safety and toxicity assessments in their studies. Common evaluations include: (1) hemolysis, platelet activation, and inflammatory responses using completed blood counts, white blood cell differential counts, and specific assays, (2) functional tests such as renal function studies and liver function tests, as well as (3) the potential tissue damage assessment in major organs using histology [133,182].…”

Section: Safetymentioning

confidence: 99%

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Kang

2020

Pharmaceutics

135

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Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

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“…A similar approach with the application of another MMP substrate, KDPLGVC peptide, was proposed by Eskandari et al [110]. The peptide was bound onto the surface of DOX-loaded MSN through amidation reaction, and then grafted with a gold nanoparticle-biotin conjugate (GNP) as end-capping and active targeting agent.…”

Section: Preprintsmentioning

confidence: 99%

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Butowska

Woziwodzka

Borowik

et al. 2021

Preprint

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Doxorubicin, a member of the anthracycline family, is a common anticancer agent often used as a first line treatment for the wide spectrum of cancers. Doxorubicin-based chemotherapy, although effective, is associated with serious side effects, such as irreversible cardiotoxicity or nephrotoxicity. Those often life-threatening adverse risks, responsible for the elongation of the patients' recuperation period and increasing medical expenses, have prompted the need for creating novel and safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be a promising approach, allowing for controlled and selective drug delivery simultaneously enhancing its activity towards cancerous cells and reducing toxic effects on healthy tissues. This article is a chronological examination of the history of the work progress on polymeric nanostructures, designed as efficient doxorubicin nanocarriers, with the emphasis on the main achievements of 2010-2020. Numerous publications have been reviewed to provide an essential summation of the nanopolymer types and their essential properties, mechanisms towards efficient drug delivery, as well as active targeting stimuli-responsive strategies that are currently utilized in the doxorubicin transportation field.

show abstract

Gold-capped mesoporous silica nanoparticles as an excellent enzyme-responsive nanocarrier for controlled doxorubicin delivery

Cited by 44 publications

References 41 publications

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

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