Gökkuşağı Alabalıklarında (Oncorhynchus Mykiss) Kadmiyum Toksisitesi: Kalp ve Kas Üzerine Bir Araştırma

Abstract

This study aims to determine and compare oxidative stress responses in muscle and heart tissues of rainbow trout (Oncorhynchus mykiss) resulting from exposure (24, 48 and 96 hours) to sub-lethal concentrations of cadmium (1, 3 and 5 mg/L). Malondialdehyde (MDA) and Peroxynitrite (ONOOˉ) parameters were studied to determine oxidative/nitrosative stress, respectively. The MDA and ONOO− values of heart and muscle tissues showed statistically significant (P<0.05) differences between each other in terms of both hours and doses. The difference in muscle tissue ONOO− and MDA values between control and other groups was found to be statistically significant (P<0.05). Similarly difference in heart tissue ONOO− and MDA values between control and other groups was found to be statistically significant (P<0.05). For both parameters as the amount of the administered dose increased, the average of the ONOO− and MDA values obtained increased significantly. As a result, it was determined that cadmium increases ONOO− and MDA levels in heart and muscle tissues, causes stress and is toxic to fish even in small doses.