Goblet Cells of the Normal Human Bulbar Conjunctiva and Their Assessment by Impression Cytology Sampling

Doughty, Michael J.

doi:10.1016/j.jtos.2012.05.001

Cited by 74 publications

(62 citation statements)

References 176 publications

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“…The large standard deviation indicates that there was a huge variation in GCD, as previously reported [2]. Contrary to what was found in the present study, Zuazo et al [22] found GCD of 497 cells/mm 2 in normal subjects and 310 cells/mm 2 in subjects with dry eyes, and Torricelli et al [4] found GCD of 521 cells/mm 2 in bulbar conjunctiva of normal subjects.…”

Section: Discussioncontrasting

confidence: 81%

“…Goblet cell density (GCD) was found lower in eyes with ocular surface disease in comparison to normal eyes [2]. The number of goblet cells decreases with contact lens wear [3].…”

Section: Introductionmentioning

confidence: 99%

“…Doughty reviewed 24 different studies which reported the effects of contact lens wear on the goblet cells of the human conjunctiva and found that there has been limited consistency in the technique or the method of reporting the results across the various studies justifying the differences obtained [3]. Additionally, GCD in conjunctival surface varies highly from one region to another and from one person to another with a range from 24 to 2226 cells/mm 2 for average values [2]. Torricelli et al [4] found higher GCD in tarsal conjunctiva in comparison to bulbar conjunctiva.…”

Section: Introductionmentioning

confidence: 99%

“…Estimation of GCD has been carried out by different ways. Although 'number of goblet cells per millimeter', 'number of goblet cells per high power field' and 'number of goblet cells per 100 basal cells' have been reported in different studies; 'number of goblet cells/mm 2 ' is the mostly used unit [2]. Generally, the numbers of cells are counted in unit field of view of the microscope and cells/mm 2 is calculated.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Goblet cell density association with tear function and ocular surface physiology

Sapkota

Franco

Sampaio

et al. 2015

Contact Lens and Anterior Eye

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Section: Discussioncontrasting

confidence: 81%

“…Goblet cell density (GCD) was found lower in eyes with ocular surface disease in comparison to normal eyes [2]. The number of goblet cells decreases with contact lens wear [3].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Goblet cell density association with tear function and ocular surface physiology

Sapkota

Franco

Sampaio

et al. 2015

Contact Lens and Anterior Eye

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“…The development of less toxic antiglaucoma treatment may reduce damage to the eye surface (Doughty 2012) and improve patient compliance towards medical therapy (Messmer et al 2012). Such improvements could improve quality of life, which is strongly affected by eye surface adverse effects in patients with glaucoma (Zimmerman et al 2009).…”

Section: Discussionmentioning

confidence: 99%

In vivo confocal microscopy of conjunctiva in preservative‐free timolol 0.1% gel formulation therapy for glaucoma

Frezzotti

Fogagnolo

Haka

et al. 2013

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the effects at 1 year of preservative-free timolol gel and preserved timolol eye drops on conjunctiva and tear parameters. Methods: Forty patients with primary open-angle glaucoma or ocular hypertension were randomized to the two treatment groups and compared with 20 healthy age-matched controls. Clinical tests (IOP, Schirmer I test, and lacrimal film break-up time BUT) and in vivo conjunctival confocal microscopy (IVCM) were performed in all patients at baseline and after 12 months. IVCM (HRT II Rostock Cornea Module; Heidelberg Engineering GmbH, Heidelberg, Germany) was performed after topical anaesthesia in the four cardinal locations and at the corresponding limbus to analyse conjunctiva cells. The main IVCM outcomes were goblet cell density and epithelial regularity. Results: IVCM and clinical parameters were similar in the three groups at baseline. After 12 months, intra-epithelial goblet cell density was significantly lower in the preserved (48.25 AE 7.70) than in the preservative-free beta-blocker group (86.83 AE 22.17, p < 0.001) and controls (88.9 AE 18.33, p < 0.001). The epithelial layer was significantly more regular in the preserved beta-blocker medication group than in the preservative-free beta-blocker group (p < 0.001) and the control group (p < 0.001). A significant reduction in both Schirmer I and BUT was found in the group of preserved timolol (respectively, 11.3 AE 2.97 and 8.12 AE 0.99) compared with preservative-free timolol (16.8 AE 1.83 and 11.27 AE 1.27, p < 0.001) and controls (17.8 AE 1.87 and 12.10 AE 1.28, p < 0.001). Conclusions: Based on our IVCM data, preservative-free beta-blocker gel induces less changes at ocular surface than preserved beta-blockers, a fact that should be considered to obtain less adverse effects and maximal adherence to treatment in a chronic condition such as glaucoma.

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Ocular Surface Anatomy and Physiology

Douglas

2023

Pediatric Ocular Surface Disease

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Goblet Cells of the Normal Human Bulbar Conjunctiva and Their Assessment by Impression Cytology Sampling

Cited by 74 publications

References 176 publications

Goblet cell density association with tear function and ocular surface physiology

Goblet cell density association with tear function and ocular surface physiology

In vivo confocal microscopy of conjunctiva in preservative‐free timolol 0.1% gel formulation therapy for glaucoma

Ocular Surface Anatomy and Physiology

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