Goblet cell density association with tear function and ocular surface physiology

Sapkota, Kishor; Franco, Sandra; Sampaio, Paula; Lira, Madalena

doi:10.1016/j.clae.2015.01.016

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…The most severe ocular surface diseases, such as Stevens-Johnson syndrome, mucous membrane pemphigoid, graft versus host disease and severe alkali burns involving the conjunctiva, often have a complete loss of conjunctival goblet cells [69,[103][104][105]. Goblet cell loss is accompanied by decreased concentration of the goblet cell mucin, MUC5AC, in tears [106] and correlates with increased conjunctival lissamine green and Rose Bengal dye staining and rapid TBUT [70,[107][108][109]. Eyes with extensive goblet cell loss often have instantaneous TBU.…”

Section: Conjunctival Diseasementioning

confidence: 99%

Defining Dry Eye from a Clinical Perspective

Ohta

Pflugfelder

Liu

et al. 2020

IJMS

155

115

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Over the past decades, the number of patients with dry eye disease (DED) has increased dramatically. The incidence of DED is higher in Asia than in Europe and North America, suggesting the involvement of cultural or racial factors in DED etiology. Although many definitions of DED have been used, discrepancies exist between the various definitions of dry eye disease (DED) used across the globe. This article presents a clinical consensus on the definition of DED, as formulated in four meetings with global DED experts. The proposed new definition is as follows: “Dry eye is a multifactorial disease characterized by a persistently unstable and/or deficient tear film (TF) causing discomfort and/or visual impairment, accompanied by variable degrees of ocular surface epitheliopathy, inflammation and neurosensory abnormalities.” The key criteria for the diagnosis of DED are unstable TF, inflammation, ocular discomfort and visual impairment. This definition also recommends the assessment of ocular surface epitheliopathy and neurosensory abnormalities in each patient with suspected DED. It is easily applicable in clinical practice and should help practitioners diagnose DED consistently. This consensus definition of DED should also help to guide research and clinical trials that, to date, have been hampered by the lack of an established surrogate endpoint.

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Section: Conjunctival Diseasementioning

confidence: 99%

Defining Dry Eye from a Clinical Perspective

Ohta

Pflugfelder

Liu

et al. 2020

IJMS

155

115

View full text Add to dashboard Cite

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“…Another study reported reduced TBUT test in 30.3% of pterygium group and 21.9% eyes without that 16 . Another study reported TBUT instability in 39.7% eyes with pterygium and in 23% eyes without it 17 . Bekibele et al 18 mentioned lower TBUT values in pterygium patients than normal eyes similar to our study.…”

Section: Resultsmentioning

confidence: 94%

Dry Eye Disease and Pterygium

Munir¹

2019

pak J Ophthalmol

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Purpose: To find the changes in tear film and ocular surface in patients with pterygium. Study Design: A descriptive cross sectional study. Place and Duration of Study: Federal Government Services Hospital Islamabad during June 2013 to December 2014. Material and Methods: Dry eye questionnaire (DEQ-6) was administered by a trained researcher and DE tests were performed in all 256 willing subjects (136 with pterygium+120 control) age 30-76 years, by a single surgeon under same physical conditions after taking the consent and approval from Hospital Ethical committee. Diagnosis was made on presence of both symptoms and tear film parameters. Statistical analysis by simple percentages. Results: Dry eyes (DE) were found in 73 (53.7%) of the pterygium cases and 28 (23.5%) of the normal patients. In this study, 55 (40.5%) patients were symptomatic, defined as reporting 1 or more DE symptoms often or all the time. There were 53 (39%) patients that showed corneal fluorescein staining (CFS) and 69 (51%) showed plugging/mucous threads in both groups. Of 136 eyes with pterygium there were 91 (67%) males and 45 (33%) females. Out of these 50 (36.7%) patients showed normal tear film and 86 (63.2%) showed deranged functions. Moreover, among the 120 control eyes there were 73 (61%) males and 47 (39%)] females. Out of these 86 (72.3%) patients were normal and 34 (27.7%) had abnormal functions. These values were reduced indicating altered tear film in these patients. Conclusion: Pterygium disturbs tear functions causing dry eye like symptoms. Key Words: Dry eye, pterygium, tear film instability, ocular surface.

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“… 3 As mentioned in an earlier study, we performed a thorough slit-lamp examination including evaluation of NIBUT as well as Schirmer’s test to ascertain the inclusion criteria of CL wear. 4 So, we suppose that there was not a significant influence of the tear film quality and quantity on the contrast sensitivity in our subjects. Yes of course it would be interesting if we measured lipid content and quality of tear debris, however, it was out of the scope of this study.…”

mentioning

confidence: 77%