GNB3 C825T and ACE I/D Polymorphisms on the Sodium–Proton Exchanger and the Prevalence of Essential Hypertension in Males

Kędzierska, Karolina; Ciechanowski, Kazimierz; Safranow, Krzysztof; Bober, Joanna; Gołembiewska, Edyta; Kwiatkowska, Ewa; Kabat‐Koperska, Joanna; Ostrowski, Marek; Adler, Grażyna; Chlubek, Dariusz

doi:10.1016/j.arcmed.2005.05.012

Cited by 12 publications

(15 citation statements)

References 18 publications

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“…38,43 K The associations between GNB3 C825T and ACE I/D polymorphisms and hypertension have been carried out, but found conflicting results in ethnic backgrounds. 23,44 What this study adds K The interaction between the GNB3 825T and ACE D alleles was found to be significantly associated with hypertension in this study. K This finding suggests that the allelic combination of two genes may contribute to the predisposing effect for the development of hypertension in Koreans.…”

Section: Discussionmentioning

confidence: 58%

“…In the recent study, Kedzierska et al 23 indicated that the presence of the GNB3 825T allele and increased activity of erythrocyte NHE independent of ACE genotype increase the risk for the development of hypertension. In particular, they suggest that the coexistence of genetic variants can lead to the disclosure of intermediate phenotype such as increased NHE activity.…”

Section: Discussionmentioning

confidence: 99%

“…The increased NHE activity in vascular smooth muscle cells can cause the increase of vascular tone and hypertrophy of vascular tunica media. 23 Thus, it was postulated that expression of Gb3s variant might contribute to the pathogenesis of EH. The recent reports indicate that the presence of GNB3 825T carriers associated with the increased activity of NHE in hypertensive subjects.…”

Section: Introductionmentioning

confidence: 99%

“…The recent reports indicate that the presence of GNB3 825T carriers associated with the increased activity of NHE in hypertensive subjects. 21,23 To date, association studies have shown that the GNB3 825T allele is significantly associated with EH in Africans 24 and Caucasians, 25 and it is also associated with variations in BP. However, the effects of the 825T allele on variations in EH and BP among Asian populations have presented conflicting results.…”

Section: Introductionmentioning

confidence: 99%

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Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

et al. 2006

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Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene-gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The G-protein b3-subunit (GNB3) 825T allele, associated with enhanced G-protein signalling, is a strong candidate for interactions with polymorphisms, such as insertion/deletion (I/D) polymorphism of angiotensin I-converting enzyme (ACE) gene. We investigated whether there is an association between GNB3 C825T and ACE I/D polymorphisms for the development of EH. We carried out a case-control study of 688 hypertensive and 924 normotensive subjects recruited from South Korea. The GNB3 C825T and ACE I/D genotypes were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism methods, respectively. The distributions of alleles and genotypes for the GNB3 C825T and ACE I/D polymorphisms were not found to be significantly associated with hypertensive status in either males or females. Logistic regression analysis indicated that the GNB3 825T allele carriers were positively associated with EH in males (odds ratio (OR) for TT/CT, 1.459; 95% confidence interval (CI), 1.048-2.033, P ¼ 0.0255). In analysis of gene-gene interaction, we found that there was a significant interaction between the GNB3 825T and ACE D alleles (Po0.05). OR for EH was significantly higher in 825T allele carriers with ACE D allele (OR, 1.490; 95% CI, 1.117-1.987, P ¼ 0.0067). A significant interaction between the GNB3 825T and the ACE D alleles may contribute to the predisposing effect for the development of EH in Koreans.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans

et al. 2006

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“…Essential hypertension was significantly associated (P < 0.01) with 825T carriers with the ACE D allele in a case-control study of 688 hypertensive and 924 normotensive subjects. Nevertheless, a current study in a small cohort of white subjects was not able to replicate these findings [105].…”

Section: G-protein Interactionsmentioning

confidence: 65%