Gnathic and peripheral ameloblastomas lack human papillomavirus DNA

Verduin, Lindsey; Bishop, Justin A.; Mills, Stacey E.

doi:10.1016/j.anndiagpath.2015.06.006

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Recently, some authors have reported molecular results about altered gene signatures in ameloblastoma, and others have attempted to evaluate the presence of the human papillomavirus (HPV) and Epstein-Barr virus (EBV) in OT tissues as a hypothetical etiological agent. However, there is still insufficient data in the literature to consider these viruses as markers of prognosis as it happens in cervical or nasopharyngeal cancer [5][6][7][8][9]. Previously, observing some epidemiological data in the Lacor Hospital in Uganda, we discussed the hypothesis that the Lassa virus (LASV) could be a virus related to OT [10].…”

Section: Introductionmentioning

confidence: 99%

Detection of the Lassa Virus in a Group of Odontogenic Bone Tumor Tissues

de Feo,

Dilu Tamba,

Makaka Mutondo

et al. 2024

Anatomia

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Odontogenic bone tumor (OT) is a rare pathology in the world, but it is very common in developing countries; its etiology is still unknown, and it causes serious deformities of the mandible and maxilla if it is not operated upon soon. Lassa virus (LASV) belongs to the Arenaviridae family, and its reservoir is a rodent of the genus Mastomys. The transmission of the LASV to humans can occur through ingestion or inhalation by contact with dirty objects, the consumption of contaminated food, or exposure to wounds, as rodents shed the virus in their urine and excrement. In this observational study, we aim to evaluate the presence of LASV in OT patient tissues collected in the Democratic Republic of the Congo. For this purpose, a group of nine patients affected by OT were enrolled, and the tissues derived from the surgery were collected. In total, 81.5% of the tissues were positive for LASV presence. Interestingly, we found that not only was the tumor LASV-positive, but in some cases, the bone was close to the tumor and the oral mucosa lining. These preliminary data could suggest the hypothesis that LASV may be involved with the onset of OT.

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