“…GMAP210 relocates to the medial compartment in the presence of Brefeldin-A (Rios et al, 1994), co-purifies with microtubules (Infante et al, 1999; Kim et al, 2007), and, when over-expressed, breaks down the Golgi into aggregates of small vesicles (Pernet-Gallay et al, 2002) and perturbs the organization of the microtubule network (Infante et al, 1999). GMAP210 is necessary for maintaining the integrity of the Golgi ribbon (Rios et al, 2004; Yadav et al, 2009). The C-terminal region of GMAP210 contains a GRAB domain (GRIP-related Arf binding domain, Gillingham et al, 2004) that specifically binds flat membranes in an Arf1-dependent manner in in vitro assays (Drin et al, 2008).…”