The significance of TRIP11 and T3 signaling pathway in renal cancer progression and survival of patients.

Popławski, Piotr; Piekiełko-Witkowska, Agnieszka; Nauman, A

doi:10.5603/ep.a2017.0052

Cited by 3 publications

(2 citation statements)

References 36 publications

(61 reference statements)

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“…It was observed that TRIP11 expressions correlated with tumor grades of renal cell cancer and decreased expression correlated with poor survival of patients, which might be associated with triiodothyronine signaling pathway. 13 The present study confirmed the poor prognosis of patients with CLMN low expression, suggesting the possibility of triiodothyronine signaling pathway involvement in breast cancer. The metabolic etiology of breast cancer has been explored during the past years using metabolomics.…”

Section: Discussionsupporting

confidence: 82%

Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma

Liu

Cheng

et al. 2021

IJGM

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Objective Function of calmin (CLMN) was rarely reported in human diseases, especially in tumor. Present study initially assessed the significance of CLMN in breast invasive carcinoma (BRCA). Methods Expressions of CLMN containing mRNA and protein in BRCA was firstly assessed, and association of CLMN mRNA expression with clinical phenotypes of BRCA patients was analyzed as well. Prognostic value of CLMN in BRCA was subsequently predicted based on the clinical characteristics of patients. Finally, the potential biological function associated with CLMN involved in BRCA was revealed. Results (1) The mRNA expression of CLMN was lower in BRCA compared with that in normal patients ( P <0.001). However, result of CLMN total protein expression was opposite ( P <0.05). (2) The mRNA expression of CLMN was statistically associated with BRCA patient’s age, gender, PR status, ER status, histological type, tumor stage, copy number, and methylation level (all P <0.05). (3) Compared with low expression group, high expression of CLMN was conducive to the overall survival of BRCA patients ( P =0.0011). Detailed, survival difference between CLMN high and low expression groups was observed in patients with stage 1 ( P =0.0250), positive ER status ( P =0.0042), negative HER status ( P =0.0433), luminal A ( P =0.0065), luminal B ( P =0.0123) and positive lymph node status ( P =0.0069). Pathway analysis suggested that CLMN mainly participated in cell cycle process ( P <0.05) and exerted inhibition effect on the cell cycle involved in BRCA ( P <0.05). Conclusion CLMN mRNA high expression prolonged the survival time of patients and caused a favorable prognosis. The positive function of CLMN in BRCA required further investigation in future work.

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Section: Discussionsupporting

confidence: 82%

Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma

Liu

Cheng

et al. 2021

IJGM

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“…HACE1 is an E3 ligase downregulated in several cancers, including gastric cancer and breast cancer, and was found to inhibit the Wnt/β-catenin pathway, thereby playing a role in suppressing tumorigenesis [32, 33]. The pathway involving TRIP11 and triiodothyronine is necessary for localization of TRIP11 to the nucleus and was found to be disrupted in renal cell cancer, leading to progression [34]. Finally, COL5A1 has been found to have associations with gastric cancer, non-small cell lung cancer, and renal cancer [35–37].…”

Section: Discussionmentioning

confidence: 99%

An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia

et al. 2019

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Background Pediatric cancer survival rates overall have been improving, but neuroblastoma (NBL) and acute lymphoblastic leukemia (ALL), two of the more prevalent pediatric cancers, remain particularly challenging. One issue not yet fully addressed is distinctions attributable to age of diagnosis. Methods In this report, we verified a survival difference based on diagnostic age for both pediatric NBL and pediatric ALL datasets, with younger patients surviving longer for both diseases. We identified several gene expression markers that correlated with age, along a continuum, and then used a series of age-independent survival metrics to filter these initial correlations. Results For pediatric NBL, we identified 2 genes that are expressed at a higher level in lower surviving patients with an older diagnostic age; and 4 genes that are expressed at a higher level in longer surviving patients with a younger diagnostic age. For pediatric ALL, we identified 3 genes expressed at a higher level in lower surviving patients with an older diagnostic age; and 17 genes expressed at a higher level in longer surviving patients with a younger diagnostic age. Conclusions This process implicated pan-chromosome effects for chromosomes 11 and 17 in NBL; and for the X chromosome in ALL. Electronic supplementary material The online version of this article (10.1186/s12935-019-0790-5) contains supplementary material, which is available to authorized users.

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Paradigms of Dynamic Control of Thyroid Hormone Signaling

et al. 2019

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The significance of TRIP11 and T3 signaling pathway in renal cancer progression and survival of patients.

Cited by 3 publications

References 36 publications

Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma

Potential Significance and Clinical Value Explorations of Calmin (CLMN) in Breast Invasive Carcinoma

An age-based, RNA expression paradigm for survival biomarker identification for pediatric neuroblastoma and acute lymphoblastic leukemia

Paradigms of Dynamic Control of Thyroid Hormone Signaling

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