GM‐CSF, IL‐5 and RANTES immunoreactivity and mRNA expression in chronic hyperplastic sinusitis with nasal polyposis (NP)

Hamilos, Daniel L.; Leung, Donald Y.M.; Huston, David P.; Kamil, A.; Wood, Raymond P.; Hamid, Qutayba

doi:10.1046/j.1365-2222.1998.00380.x

Cited by 167 publications

(128 citation statements)

References 34 publications

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“…It has been speculated that nasal inflammation induced by IgE-mediated mechanisms favors the development of acute and/or chronic sinus disease. A similar inflammation is observed in the nose and sinuses of patients with allergic rhinitis (2090)(2091)(2092)(2093)(2094)(2095). Moreover, sinus involvement has been observed by CT scans in allergic patients during the ragweed pollen season (2096).…”

Section: Rhinosinusitissupporting

confidence: 48%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

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Section: Rhinosinusitissupporting

confidence: 48%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

View full text Add to dashboard Cite

“…Fibroblasts can produce RANTES (3,4), eotaxin (54), monocyte chemoattractant protein-1, IL-8, GM-CSF, G-CSF, or TGF-␤ (55). RANTES proteins were highly detected in nasal polyps compared with control normal mucosa (7). Cultured nasal polyps release RANTES to attract and activate eosinophils (5,6,8).…”

Section: Discussionmentioning

confidence: 95%

Protein-Tyrosine Kinase Syk Expressed in Human Nasal Fibroblasts and Its Effect on RANTES Production

Yamada

Fujieda

Yanagi

et al. 2001

The Journal of Immunology

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Fibroblasts, a rich source of chemokines, interact with eosinophils and play a key role in the pathogenesis of airway disease. RANTES is produced by fibroblasts to attract and activate eosinophils. LPS is known to induce RANTES and cause protein tyrosine phosphorylation. Nonreceptor protein tyrosine kinase Syk is widely expressed and an important role in intracellular signal transduction in hemopoietic cells. In the present study, we examined whether Syk was expressed in a number of primary human nasal polyp tissue-derived fibroblast lines and whether it played some role in cellular function. Syk proteins were expressed in human nasal fibroblasts, but the expression level varied. There were positive correlations between the level of Syk expression and RANTES production induced by LPS. Overexpression of wild-type Syk by gene transfer enhanced RANTES production from nasal fibroblasts stimulated with LPS. The decrease of Syk expression by the administration of Syk antisense inhibited RANTES production. These results suggest that Syk expression affects RANTES production in fibroblasts of nasal polyps.

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“…9,13,14,15 Because eosinophils themselves are a prominent source of many of these mediators, CHES can best be thought of as a disease of unrestrained self-perpetuating inflammation and that once eosinophils are recruited, they provide the growth factors necessary for their further recruitment, proliferation, activation, and survival. 13,14,16,17 This certainly is consistent with the chronicity of this disorder and the requirements for frequent surgical revisions. As such, although allergy might be important in precipitating or possibly exacerbating the disorder, it has to be recognized that ongoing allergen exposure may not be required for its persistence.…”

Section: Immune Mechanisms Of Chesmentioning

confidence: 99%