Glyproline peptide family: review on bioactivity and possible origins

Samonina, G. E.; Ashmarin, I.Р.; Lyapina, L. A.

doi:10.1016/s0928-4680(02)00018-4

Cited by 51 publications

(30 citation statements)

References 31 publications

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“…In contrast, there is some evidence that the intestinal transport of peptides or macromolecules may give, to a small but significant extent, antigens or biologically active substances. [28][29][30][31][32][33] Various positive affects of the oral administration of a gelatin and gelatin hydrolysate have been proposed. [4][5][6][7][8] The underlying mechanisms responsible for these effects have not been fully demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Absorption of Hydroxyproline-Containing Peptides in Vascularly Perfused Rat Small Intestinein Situ

Liu

Sugita

Nihei

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 99%

Absorption of Hydroxyproline-Containing Peptides in Vascularly Perfused Rat Small Intestinein Situ

Liu

Sugita

Nihei

et al. 2009

Bioscience, Biotechnology, and Biochemistry

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“…Cyclic dipeptides have been reported to exhibit physiological activities such as anti-tumour (Arunrattiyakorn et al 2007, He et al 1999, van Loevezijn et al 1999, anti-viral (Watson et al 2005), and anti-bacterial (Houston et al 2004, Park et al 2006 effects. Cyclo(-Gly-Pro), a type of cyclic dipeptide, was reported to demonstrate physiological activities such as antiamnesic effects (Gudasheva et al 1996, Samonina et al 2002 and neuroprotective actions (Guan and Peter 2009).…”

Section: Introductionmentioning

confidence: 99%

Production Method for Cyclic Dipeptide Derived from Native Collagen

Hayasaka

Yamamoto

Sakai

2016

FSTR

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In this study, a new method for producing cyclo(-Gly-Pro) using collagen as a raw material was examined.First, collagen was enzymatically hydrolysed and purified to obtain collagen tripeptide (CTP), rich in "Gly-X-Y" tripeptides. After heating this product under atmospheric pressure in an aqueous solution at 95℃ for 24 h, purification was achieved by reverse-phase column chromatography. The isolated component was confirmed to be cyclo(-Gly-Pro) through structural analysis by MS and NMR spectroscopies. Purity was determined to be 93.6%, and the recovery rate from CTP was 22%, indicating that much Gly-Pro-Y in CTP contributed to cyclization. The cyclization rate from Gly-Pro-Hyp or Gly-Pro-Ala was much higher than that of Gly-Pro, suggesting that cyclo(-GlyPro) was efficiently generated from the Gly-Pro-Y sequence. In summary, this is a simple, practical manufacturing method for producing cyclo(-Gly-Pro) from collagen at low cost with high efficiency.

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“…They maintain homeostasis in the gastric mucosa under ulcerogenic conditions, prevent microcirculatory disturbances [2], inhibit thrombus formation [8], and are involved in the regulation of vascular tone [1].…”

mentioning

confidence: 99%

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

et al. 2006

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The development of acute peritonitis in rats induced by intraperitoneal injection of thioglycollate was accompanied by a decrease in contractile function of mesenteric lymphatic vessels and impaired response to norepinephrine. Administration of proline-containing peptides after induction of inflammation significantly decreased the severity of these disorders. Our results attest to the possibility of using peptides for the correction of mesenteric microcirculatory disturbances during inflammation.

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Glyproline peptide family: review on bioactivity and possible origins

Cited by 51 publications

References 31 publications

Absorption of Hydroxyproline-Containing Peptides in Vascularly Perfused Rat Small Intestinein Situ

Absorption of Hydroxyproline-Containing Peptides in Vascularly Perfused Rat Small Intestinein Situ

Production Method for Cyclic Dipeptide Derived from Native Collagen

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

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