Glyphosate differentially affects the allergic immune response across generations in mice

Buchenauer, Lisa; Junge, Kristin M.; Haange, Sven-Bastiaan; Simon, Jan C.; Bergen, Martin von; Hoh, Anna-Lena; Aust, Gabriela; Zenclussen, Ana Claudia; Stangl, Gabriele I.; Polte, Tobias

doi:10.1016/j.scitotenv.2022.157973

Cited by 13 publications

(6 citation statements)

References 63 publications

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“…For example, paraquat enriches the gene expression for IL17 signalling in human cells ( 45 ). Murine exposure to glyphosate leads to IL-17A reduction in peripheral blood at low doses and has been linked to immune deregulation across generations ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Santos,

da Silva,

Jaques

et al. 2023

Front. Immunol.

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Pesticides are compounds known to cause immunetoxicity in exposed individuals, which have a potential to substantially modify the prognosis of pathologies dependent on an efficient immune response, such as breast cancer. In this context, we examined the circulating cytokine profile of Th1/Th2/Th17 patterns in women occupationally exposed to pesticides and their correlation with worse prognostic outcomes. Peripheral blood samples were collected from 187 rural working women with breast cancer, occupationally exposed or not to pesticides, to quantify the levels of cytokines IL-1β, IL-12, IL-4, IL-17-A, and TNF -α. Data on the disease profile and clinical outcomes were collected through medical follow-up. IL-12 was reduced in exposed women with tumors larger than 2 cm and in those with lymph node metastases. Significantly reduced levels of IL-17A were observed in exposed patients with Luminal B subtype tumors, with high ki67 proliferation rates, high histological grade, and positive for the progesterone receptor. Reduced IL-4 was also seen in exposed women with lymph node invasion. Our data show that occupational exposure to pesticides induces significant changes in the levels of cytokines necessary for tumor control and correlates with poor prognosis clinical outcomes in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Santos,

da Silva,

Jaques

et al. 2023

Front. Immunol.

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“…Maternal exposure to GLY or GBH has reported impacts on cardiac parameters ( de Marins et al , 2023 ), anxiety and hyperactivity ( de Castro Vieira Carneiro et al , 2023 ), immune responsivity ( Buchenauer et al , 2022 ), hepatic function ( Rieg et al , 2022 ; Teleken et al , 2020 ), and muscle structure ( Barbosa et al , 2022 ) in offspring and although the species and route of exposure differ, the potential for maternal exposure to impair offspring viability is supported. This study investigated a maternal pre-conceptional exposure to GLY at a dose not previously determined to be of concern for development and reproduction ( Ganesan and Keating, 2020 ; Ganesan et al , 2020 ; USEPA, 1993 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome

Novbatova

Timme

Severin

et al. 2023

Toxicological Sciences

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Glyphosate (GLY) is an herbicide used for rural and urban weed control. Urinary GLY in women is associated with shortened gestational length yet effects of GLY on offspring due to maternal exposure are unclear. This study tested the hypothesis that maternal chronic pre-conceptional GLY exposure would cause phenotypic and molecular changes in F1 offspring. Female C57BL/6 mice (7 wk old; n = 40) received saline vehicle control (CT; n = 20) or GLY (2 mg/Kg; n = 20) daily per os for ten weeks. At dosing completion, females were housed with unexposed males and divided into Cohort 1 who were euthanized at gestation day (GD) 14 (n = 10 per treatment), and Cohort 2 who completed gestation (n = 10 per treatment). F1 female ovarian and liver samples underwent LC-MS/MS and bioinformatic analysis. Maternal exposure did not affect litter (P > 0.05) sex ratio, or embryonic or neonatal gross phenotypes. In Cohort 2 offspring, no treatment effect on (P > 0.05) offspring anogenital distance, puberty onset or ovarian follicular composition was noted. Body weight was increased (P < 0.05) in male GLY-exposed compared to CT dam offspring. F1 females from GLY-exposed dams, had altered (P < 0.05) abundance of 54 ovarian and 110 hepatic proteins. Pathways altered in the ovary (FDR ≤ 0.07) included thermogenesis and PI3K-AKT signaling and in liver (FDR ≤ 0.08) included metabolic, glutathione metabolism, oxidative phosphorylation, non-alcoholic fatty liver disease, and thermogenesis. Thus, pre-conceptional GLY exposure affected offspring phenotypic and molecular profiles potentially impacting reproductive health.

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“…Additionally, maternal diet, nutrition, prenatal stress, supplementation of prebiotics and probiotics during pregnancy, as well as exposure to environmental pollutants, have all been proven to affect the allergic immune response across generations. However, it is unknown whether there is any direct involvement of maternal gut microbiota ( 211 – 215 ). Maternal treated with antibiotics during pregnancy was associated with increased asthma severity in the offspring in a dose-dependent way ( 194 , 216 – 218 ).…”

Section: Maternal Gut Microbiota: the Role In Offspring Healthmentioning

confidence: 99%

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

Lu,

Shi,

Jiang

et al. 2024

Front. Immunol.

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Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages. Some other evidence has also shown that aberrant maternal gut microbiota increases the risk of various diseases in the offspring, such as allergic and neurodevelopmental disorders, through the immune alignment between mother and fetus and the possible intrauterine microbiota. Probiotics and the high-fiber diet are effective inventions to prevent mothers and fetuses from diseases. In this review, we summarize the role of maternal gut microbiota in the development of pregnancy complications and the health condition of future generations from the perspective of immunology, which may provide new therapeutic strategies for the health management of mothers and offspring.

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Glyphosate differentially affects the allergic immune response across generations in mice

Cited by 13 publications

References 63 publications

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Occupational exposure to pesticides dysregulates systemic Th1/Th2/Th17 cytokines and correlates with poor clinical outcomes in breast cancer patients

Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome

Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology

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