Glyphosate-based phospho-organic herbicides – an outline of action, metabolism and the selected effects on humans and other organisms

Baran, Michał Jacek; Cibiński, Michał

doi:10.15442/apgr.19.2.10

Cited by 4 publications

(4 citation statements)

References 47 publications

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“…In Sri Lanka, increased levels of glyphosate are present in farm-lands' topsoil, indicating prolonged exposure which can be one of the causative agents for CKDu. 77 Despite the fact that the WHO considered pesticides containing arsenic as hazardous, many farmers still continue to use them as they are unaware of the harm caused by these heavy metals. 78 European Union passed a bill to limit the use of cadmium-containing fertilizers.…”

Section: Agrochemicals and Nephrotoxic Exposurementioning

confidence: 99%

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<p>Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology</p>

Abdissa¹

2020

IJNRD

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The global burden of chronic kidney disease (CKD) has risen, and chronic kidney disease of unknown etiology (CKDu) contributes considerably to the national burden of CKD. It is characterized by irreversible, slowly advancing disease, and symptoms often appear in the late stages of the disease. It is a serious, novel cause of kidney failure and leads to premature deaths. Many hypotheses have emerged; however, the etiology of CKDu continues to be elusive and debatable and it is claimed that the etiology is multifactorial, encompassing environmental, genetic, occupational, and social factors. The dominant histopathological feature is chronic tubulointerstitial nephritis. It predominantly affects individuals with low socio-economic status, of working age, largely without chronic comorbidities, who perform strenuous labor in extreme conditions in various tropical areas of the world. It is often fatal due to fast progression and limited access to dialysis or transplant options in the involved geographic areas. Early recognition and appropriate interventions at the earliest possible stage are imperative for decreasing its associated morbidity and mortality. In this review, I tried to summarize available evidence on the risk factors, epidemiology, clinical features, treatment, and prevention of CKDu. The literature search for this review was conducted comprehensively by using different electronic databases and by using appropriate search terms.

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Section: Agrochemicals and Nephrotoxic Exposurementioning

confidence: 99%

“…In Sri Lanka, increased levels of glyphosate are present in farm-lands’ topsoil, indicating prolonged exposure which can be one of the causative agents for CKDu. 77 …”

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

<p>Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology</p>

Abdissa¹

2020

IJNRD

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“…Addition of saccharin increases the populations of Lactobacillus and concentration of lactic acid in the caecum (Daly et al, 2015). It was proved that regardless of the way of introduction of glyphosate-conteining prepara-tions into organisms of human and animals, its impact can manifest in toxicity, individual disorders of metabolism, teratogenicity, disorders of cell cycle, genetic dysfunctions, endocrinous pathologies (for example, disorders in regulations of sexual functions) (Baran & Cibiński, 2014).…”

Section: Resultsmentioning

confidence: 99%

Combined effect of glyphosate, saccharin and sodium benzoate on the gut microbiota of rats

Bilan

Lieshchova

Tishkina

et al. 2019

Regul. Mech. Biosyst.

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Glyphosate is the main component of many broadly used herbicides due to its safety for humans and animals. It is known that the remains of glyphosate are present in allowable doses in fodders and food products, and, consumrd in low doses, it is found in insignificant amounts in milk, eggs and even in the internal organs (liver, kidneys) of animals. For determining combined impact of glyphosate and the commonest food additives on the composition of microbiota of animals, four groups of laboratory male rats were formed, which during 42 days consumed pure water without any restrictions; 1% aqueous solution of glyphosate; 1% solution of glyphosate in combination with 1% solution of sodium benzoate; 1% solution of glyphosate with 1% solution of saccharin. After killing the animals, 1 g of feces were collected and by serial dilutions with 10–1 to 10–9 sterile physiologic solution, a microbiological analysis was undertaken. Out of each dilution an inoculation of the studied material to the elective growth media was performed, by 0.1 cm3, then the material was incubated in a thermostat (24–72 hours, temperature 37 °С), the results were recorded after 24–72 h. The microorganisms were identified by studying morphological parameters, tinctorial, cultural and enzymic properties. Results are provided in CFU/g (colony-forming unit per gramm) of feces. The impact of glyphosate and glyphosate with food additives led to no changes in the number of Escherichia coli and emergence of this species of microorganism with changed enzymic activity. Also no changes occurred in the number of microorganisms of Bifidobactrium and Lactobacillus spp. Addition of glyphosate, and also glyphosate in combination with saccharin to the diet contributes to broader reproduction of microorganisms of Klebsiella, Citrobacter, Enterobacter and Pseudomonas genera. Mixtures of glyphosate and food additives allow conditionally pathogenic yeast-like Candida fungi (Candida glabrata and C. albicans) to spread more widely in the intestine. Significant fluctuations in the number of Enterococcus spp. bacteria genus were observed: by 80 times within range of each of the three experimental groups of rats with addition of herbicide with benzoate and saccharin to the diet.

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“…Regardless of the fact the WHO deemed glyphosate as "probably carcinogenic", the damage caused by the heavy metal can significantly impact the growth and metabolism in individuals when exposed for a long period of time [23]. In Sri Lanka increased levels of glyphosate is presented in farming lands topsoil indicating prolonged exposure which can be one of the causative agents for CKDu [24]. A study carried out in 2015 identified heat stress as the main causative factor of CKDu in Mesoamerican nephropathy patients in South America [30] and studies are ongoing currently to prove the hypothesis made by the research team.…”

Section: Socio-demographical Factorsmentioning

confidence: 99%

Risk Factors Associated with Chronic Kidney Disease of Unknown Origin (Ckdu) in North Central Province (NCP) of Sri Lanka: An Analysis of Evidence to Date

Aslam¹

2020

J COMM MED PUB HEALTH REP

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Chronic kidney disease of unknown origin (CKDu) is a global burden among the agricultural communities, this is a non-communicable disease (NCD) which is asymptomatic and irreversible until latter stages of the disease. The disease has no common features unlike chronic kidney diseases (CKD’s) making early detection impossible in the patients. The most recent form of CKDu was reported in India, known as the Indian CKDu in late 2010’s. In Sri Lanka, CKDu is highly prevalent in the north central province of the country with nearly15.1%-22.9% presented with the disease. This region is a dry-zone in which agricultural and farming activities are carried out as the main occupation. Several studies have been carried out linking CKDu to various factors such as heavy metals in water, agrochemicals, heat, dehydration and socio-demographics in NCP. Despite several researches being conducted none of them were able to prove the root cause and causative factors of the disease. Using the available articles online, studies from countries such as India, Nicaragua, Sri Lanka and South America were chosen in which heat stress, dehydration, heavy metal involvement, agrochemicals were common causative factors reported in these geographical locations. Several studies analyzed indicate that the affected CKDu population were part of the agricultural community in rural areas with less or no proper high school education and family history with CKDu. Recent findings do suggest that a combination study involving socio-demographical data and geographical data will help to end the CKDu debate worldwide and provide new insights into early diagnosis.

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Glyphosate-based phospho-organic herbicides – an outline of action, metabolism and the selected effects on humans and other organisms

Cited by 4 publications

References 47 publications

<p>Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology</p>

<p>Purposeful Review to Identify Risk Factors, Epidemiology, Clinical Features, Treatment and Prevention of Chronic Kidney Disease of Unknown Etiology</p>

Combined effect of glyphosate, saccharin and sodium benzoate on the gut microbiota of rats

Risk Factors Associated with Chronic Kidney Disease of Unknown Origin (Ckdu) in North Central Province (NCP) of Sri Lanka: An Analysis of Evidence to Date

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