Glycyrrhizic acid from licorice down-regulates inflammatory responses <i>via</i> blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation

Liu, Wenfeng; Huang, Shun; Li, Yonglian; Li, Yanwen; Li, Dongli; Wu, Panpan; Wang, Quanshi; Zheng, Xi; Zhang, Kun

doi:10.1039/c8md00288f

Cited by 27 publications

(18 citation statements)

References 30 publications

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“…The neuroprotective effect of AG was associated with a significant reduction in IL-1, TNF-α, COX-2, iNOS, NF-κB, and GFAP levels [60]. Further recent studies showed that AG downregulates the expression of iNOS and COX-2 in the inflamed kidney [61] and skin [62], blocking NF-κB activation. In HaCaT cells, AG inhibited the UV-B-mediated increase in intracellular ROS and downregulated the release of IL-6, IL-1α, IL-1β, TNF-α, and PGE 2 [63].…”

Section: Discussionmentioning

confidence: 99%

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

et al. 2019

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The object of the study was to estimate the long-lasting effects induced by ammonium glycyrrhizinate (AG) after a single administration in mice using animal models of pain and inflammation together with biochemical and docking studies. A single intraperitoneal injection of AG was able to produce anti-inflammatory effects in zymosan-induced paw edema and peritonitis. Moreover, in several animal models of pain, such as the writhing test, the formalin test, and hyperalgesia induced by zymosan, AG administered 24 h before the tests was able to induce a strong antinociceptive effect. Molecular docking studies revealed that AG possesses higher affinity for microsomal prostaglandin E synthase type-2 compared to type-1, whereas it seems to locate better in the binding pocket of cyclooxygenase (COX)-2 compared to COX-1. These results demonstrated that AG induced anti-inflammatory and antinociceptive effects until 24–48 h after a single administration thanks to its ability to bind the COX/mPGEs pathway. Taken together, all these findings highlight the potential use of AG for clinical treatment of pain and/or inflammatory-related diseases.

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Section: Discussionmentioning

confidence: 99%

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

et al. 2019

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“…Previous studies demonstrated that MAPK signal pathway was involved in the inflammation reaction and oxidative stress [26,27]. Some researchers also found that the ingredients of licorice has the function to mediate the expression of MAPK signaling pathway [28,29].…”

Section: Discussionmentioning

confidence: 99%

Potential Pharmacodynamic Mechanism of the Main ingredients in Licorice for Chronic Obstructive Pulmonary Disease

Cai

Shen

et al. 2021

Preprint

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Purpose: This study aimed to investigate the effect of essential ingredients of licorice on the chronic obstructive pulmonary disease (COPD). Method: The ingredients information were obtained from PubChem (https://pubchem.ncbi.nlm.nih.gov/), related genes about COPD was collected from geneCards (http://www.genecards.org/). Network pharmacology was utilized in this study. Result: The intersection data set contains 20 molecular targets between COPD and liquorice. Protein-protein interaction network showed that there are a total of 58 nodes and 137 edges involved. The link number of AKT1 in PPI network was 39, which is the highest level of interaction. MAPK1 is an important target of Licorice on COPD. Conclusion: MAPK signaling pathway could be the important key target of main ingredients of licorice on COPD.

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“…Previously, many studies revealed that levels of MMPs are regulated by activated NF-κB, AP-1, and MAPK signaling pathways [ 23 , 32 , 33 , 34 , 35 ]. UV irradiation leads to MAPK phosphorylation, which then directly affects the phosphorylation of nuclear transcription factor AP-1 (c-Jun).…”

Section: Discussionmentioning

confidence: 99%

Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-κB Signaling Pathways

Ding

Jiratchayamaethasakul

Lee

2020

IJMS

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Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin photoaging. The purpose of this study is to investigate the protective effect of protocatechuic aldehyde (PA), which is a nature-derived compound, against UVA-induced photoaging by using human dermal fibroblast (HDF) cells. In this study, our results indicated that PA significantly reduced the levels of intracellular ROS, nitric oxide (NO), and prostaglandins-E2 (PGE2) in UVA-irradiated HDF cells. It also inhibited the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Besides, PA significantly suppressed the expression of matrix metalloproteinases-1 (MMP-1) and pro-inflammatory cytokines and promoted collagen synthesis in the UVA-irradiated HDF cells. These events occurred through the regulation of activator protein 1 (AP-1), nuclear factor-κB (NF-κB), and p38 signaling pathways in UVA-irradiated HDF cells. Our findings suggest that PA enhances the protective effect of UVA-irradiated photoaging, which is associated with ROS scavenging, anti-wrinkle, and anti-inflammatory activities. Therefore, PA can be a potential candidate for the provision of a protective effect against UVA-stimulated photoaging in the pharmaceutical and cosmeceutical industries.

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Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-κB signalling pathways in TPA-induced skin inflammation

Abstract: Glycyrrhizinic acid (GA), a principal component derived from licorice, is attracting considerable attention because of its broad range of bioactivities.

Cited by 27 publications

References 30 publications

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

Potential Pharmacodynamic Mechanism of the Main ingredients in Licorice for Chronic Obstructive Pulmonary Disease

Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-κB Signaling Pathways

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