Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation

Byrne, Mark E.; Mildner, Robert; Menzel, Henning; Heise, Andreas

doi:10.1002/mabi.201400371

Cited by 21 publications

(20 citation statements)

References 39 publications

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“…With the addition of more galactose the helicity increases to 55.6%. This is in contrast to the recently reported decrease of helicity with increasing degree of amino sugars directly attached to poly(glutamic acid) [30,39]. Without a further systematic study it can only be speculated that this is due to the different side chain structures of both systems.…”

Section: Resultscontrasting

confidence: 83%

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Kapetanakis

Heise

2015

European Polymer Journal

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Section: Resultscontrasting

confidence: 83%

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Kapetanakis

Heise

2015

European Polymer Journal

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“…In a very recent work these PGA based star polypeptides were glycosylated. Glycosylation of star-shaped poly(glutamic acid) resulted in the formation of a diverse range of glycopolypeptide architectures with tuneable degree of sugar conjugation [200]. The secondary structure of the branched glycopolypeptides was studied as a function of the degree glycosylation.…”

Section: Non-linear Polypeptide Architectures: Star Brush and Higmentioning

confidence: 99%

Strategies to Fabricate Polypeptide-Based Structures via Ring-Opening Polymerization of N-Carboxyanhydrides

2017

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Abstract:In this review, we provide a general and clear overview about the different alternatives reported to fabricate a myriad of polypeptide architectures based on the ring-opening polymerization of N-carbonyanhydrides (ROP NCAs). First of all, the strategies for the preparation of NCA monomers directly from natural occurring or from modified amino acids are analyzed. The synthetic alternatives to prepare non-functionalized and functionalized NCAs are presented. Protection/deprotection protocols, as well as other functionalization chemistries are discussed in this section. Later on, the mechanisms involved in the ROP NCA polymerization, as well as the strategies developed to reduce the eventually occurring side reactions are presented. Finally, a general overview of the synthetic strategies described in the literature to fabricate different polypeptide architectures is provided. This part of the review is organized depending on the complexity of the macromolecular topology prepared. Therefore, linear homopolypeptides, random and block copolypeptides are described first. The next sections include cyclic and branched polymers such as star polypeptides, polymer brushes and highly branched structures including arborescent or dendrigraft structures.

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“…By deprotection the PZLL star polypeptides comprising PLL arms were obtained, while deprotection of the PBLG stars produced pH‐responsive PGA star polypeptides. The latter were further used to study glycosylation and subsequent lectin binding as a function of star polypeptide architecture and molecular weight …”

Section: Synthesis Of Polypeptide Star Polymersmentioning

confidence: 99%

Star‐Shaped Polypeptides: Synthesis and Opportunities for Delivery of Therapeutics

Byrne

Murphy

Kapetanakis

et al. 2015

Macromol. Rapid Commun.

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Significant advances in the synthesis of polypeptides by N-carboxyanhydride (NCA) polymerisation over the last decade have enabled the design of advanced polypeptide architectures such as star-shaped polypeptides. These materials combine the functionality offered by amino acids with the flexibility of creating stable nanoparticles with adjustable cargo space for therapeutic delivery. This review highlights recent advances in the synthesis of star polypeptides by NCA polymerisation followed by a critical review of the applications of this class of polymer in the delivery of therapeutic agents. This includes examples of traditional small-molecule drugs as well as the emerging class of biologics such as genetic therapeutics (gene delivery).

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Glycosylated Star Polypeptides from NCA Polymerization: Selective Binding as a Function of Degree of Branching and Glycosylation

Cited by 21 publications

References 39 publications

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

Strategies to Fabricate Polypeptide-Based Structures via Ring-Opening Polymerization of N-Carboxyanhydrides

Star‐Shaped Polypeptides: Synthesis and Opportunities for Delivery of Therapeutics

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