Glycosylated Haemoglobin in Uraemia

Paisey, Richard; Banks, Richard; Holton, Ronald H.; Young, Kim Ji; Hopton, M.; White, Desirée A.; Hartog, M.

doi:10.1111/j.1464-5491.1986.tb00788.x

Cited by 37 publications

(21 citation statements)

References 12 publications

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“…Although we did not find a significant cor relation between them, mean values of GHb and PGP were significantly higher in those patients which showed a worse oral glucose tolerance. Paisey et al [40] reported that GHb measured by two different methods correlated with postprandial blood glucose levels in patients with stable chronic renal failure. Normal fasting and high postprandial glucose values in end-stage renal disease patients would explain the bad correlation between fast ing glycemia and glycosylation parameters in the pres ence of high levels of GHb and total PGP.…”

Section: Discussionmentioning

confidence: 99%

Nonenzymatic Glycosylation of Hemoglobin and Total Plasmatic Proteins in End-Stage Renal Disease

et al. 1991

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In order to ascertain whether there are abnormalities of nonenzymatic glycosylation in uremia, the levels of nonenzymatically glycosylated hemoglobin (GHb), and total plasmatic glycosylated proteins (PGP) were studied using the thiobarbituric acid (TBA) method, a procedure not interfered with by carbamylation. Total hemoglobin A₁ (HbA₁) and the A_1c fraction were also determined by ion exchange chromatographic methods. Sixty-six end-stage renal disease patients (29 nondiabetic and 8 diabetic uremic patients on conservative treatment, 29 non-diabetic hemodialysis patients) and 56 controls (32 nonuremic diabetic patients and 24 healthy controls) were studied. High levels of GHb and total PGP were found in the nondiabetic uremic group on conservative treatment with all the methods used, but the persistence of high chromatographically determined HbA₁ levels in hemodialysis patients contrasts with the results obtained with the other techniques, which showed lower values on hemodialysis. Nondiabetic uremic patients with abnormal oral glucose tolerance curves had significantly higher levels of TBA-determined GHb and PGP. Uremic diabetic patients had the highest glycosylation levels of all the studied groups. We conclude that there is an abnormal nonenzymatic glycosylation of proteins in uremia, independent of carbamylation reactions and partially corrected by hemodialysis.

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Section: Discussionmentioning

confidence: 99%

Nonenzymatic Glycosylation of Hemoglobin and Total Plasmatic Proteins in End-Stage Renal Disease

et al. 1991

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“…In vitro studies (1 1) and multivariate in vivo analyses (12,13) have failed to confirm this, however. Another study reported a change in the overall rate of nonenzymatic glycosylation caused by azotemia (14).…”

Section: Is the Rate Of Glycosylation Altered By Uremia?mentioning

confidence: 95%

The Use of Glycosylated Hemoglobin in Dialysis Patients

Tzamaloukas

1998

Seminars in Dialysis

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“…La hemoglobina glucosilada A 1C (HbA 1C ) es el parámetro de referencia para valorar el control metabólico en el paciente con insuficiencia renal crónica (IRC), teniendo presentes los factores que limitan su utilidad como marcador de control glucémico, como las transfusiones y el tratamiento con eritropoyetina [38][39][40][41][42][43] .…”

Section: Manejo De La Hiperglucemia En La Enfermedad Renal Crónicaunclassified

Documento de consenso para la detección y manejo de la enfermedad renal crónica

Martínez‐Castelao

Górriz

Bover

et al. 2014

Hipertensión y Riesgo Vascular

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RESUMENLa enfermedad renal crónica (ERC) es un importante problema de salud pública que puede afectar en sus diferentes estadios a cerca del 10 % de la población española y que supone una elevada morbilidad y mortalidad, así como un importante consumo de recursos al Sistema Nacional de Salud. Diez sociedades científicas involucradas en el manejo del paciente renal nos hemos puesto de acuerdo para hacer una puesta al día del anterior documento de consenso sobre ERC de 2007. El presente es la edición abreviada del documento general extenso, que puede ser consultado en las páginas web de cada una de las sociedades firmantes. Contiene los siguientes aspectos: definición, epidemiología y factores de riesgo de la ERC. Criterios de diagnóstico, evaluación y estadiaje de la ERC, albuminuria y estimación del filtrado glomerular. Concepto y factores de progresión. Criterios de derivación a Nefrología. Seguimiento del paciente, actitudes y objetivos por especialidad. Prevención de la nefrotoxicidad. Detección del daño cardiovascular. Actitudes, estilo de vida y tratamiento: manejo de la hipertensión arterial, dislipemia, hiperglucemia, tabaquismo, obesidad, hiperuricemia, anemia, alteraciones del metabolismo mineral y óseo. Seguimiento coordinado por Atención Primaria-otras especialidades-Nefrología. Manejo del paciente en tratamiento renal sustitutivo, hemodiálisis, diálisis peritoneal y trasplante renal. Tratamiento paliativo de la uremia terminal. Esperamos que sirva de gran ayuda en el manejo multidisciplinar del paciente con ERC, a la vista de las recomendaciones más actualizadas.

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Glycosylated Haemoglobin in Uraemia

Cited by 37 publications

References 12 publications

Nonenzymatic Glycosylation of Hemoglobin and Total Plasmatic Proteins in End-Stage Renal Disease

Nonenzymatic Glycosylation of Hemoglobin and Total Plasmatic Proteins in End-Stage Renal Disease

The Use of Glycosylated Hemoglobin in Dialysis Patients

Documento de consenso para la detección y manejo de la enfermedad renal crónica

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