Glycosylated &amp;beta;-lipoprotein, Diabetes Mellitus and Atherosclerosis

道彦, 早川; 芳郎, 岩田; 文男, 葛谷

doi:10.5551/jat1973.14.1_31

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Several studies inform that free radicals and reactive oxygen species increased in DM rats and patients (34)(35)(36)(37)(38). Lipid peroxidation occurring due to free oxygen radicals is one of the most important causes of cell damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Öztürk¹,

Erdoğan²,

Ekici³

et al. 2016

West Indian Med J

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Objectives: Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ET A R) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). Methods: In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ+BQ-123 groups. Experimental diabetes was induced by delivering a single dose of 60 mg/kg intravenous STZ. The rats in the STZ+BQ-123 group received 4 mg/kg i.v.in total BQ-123 (2 mg/kg +2 mg/kg on the 39th and 40th days). The plasma specimens collected 6 hours after the last BQ-123 delivery were studied for biochemical parameters. Results: At the end of the experiment, the weights of rats in the STZ and STZ+BQ-123 groups were significantly lower compared with the values in the Control group. The levels of blood glucose were significantly higher in the STZ and STZ+BQ-123 groups than in the Control group. While rats with STZinduced diabetes demonstrated no changes in Leptin, PC and K + levels, they exhibited reduced NO, Na + and Clconcentrations. The levels of plasma TBARS was significantly higher in the STZ group than in the Control and STZ+BQ-123 groups. Conclusion: Although the levels of plasma Leptin was no statistically significant difference between the groups, BQ-123 groups lead to further decrease in reduced levels of Leptin than only diabetic group. Our findings have been considered that ET A R antagonists have positive impacts depending on the dosage in the diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Öztürk¹,

Erdoğan²,

Ekici³

et al. 2016

West Indian Med J

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“…"Free radical reactions and non-enzymatic glycosylation may play important roles not only in the development of diabetes but also in its complications" 67 .…”

Section: Diabetesmentioning

confidence: 99%

Potential of Cydonia oblonga leaves in cardiovascular disease.

Vaez¹,

Hamidi²,

Arami³

2014

HYP

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Nowadays plant-based medicine or herbal medicine research is becoming more prevalent all over the world, presumably due to natural accessibility and fewer adverse effects. Quince (Cydonia oblonga Miller), a plant in the Rosaceae family, is considered to be a good and cheap natural source for potent antioxidants including phenolic acids and flavonoids. There have been limited investigations on the efficacy of quince leaves in heart function. The potential for prophylactic and therapeutic effects of quince leaves in reducing cardiovascular disease is discussed based on its beneficial constituents. The review covers the findings from traditional medicines and various actions of effective constituents demonstrated in other investigations including antioxidant, antiatherogenic, antiinflammation, antihypertensive and vasodilatory effects, which all are in accordance with the hypothesis of a beneficial role of quince in cardiovascular health.

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“…Reactive oxygen species (ROS) have been shown to be central during the pathogenesis of several diseases including diabetes mellitus [1], aging [2] and Alzheimer's disease [3]. Normal metabolism usually leads to the formation of ROS such as superoxide and hydroxyl radicals.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Cytotoxicity and Cytoprotective Potential of Extracts ofGrewia FlavaandGrewia BicolorBerries

et al. 2021

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Objectives: Accumulation of cellular reactive oxygen species (ROS) leads to oxidative stress. Increased production of ROS, such as superoxide anion, or a deficiency in their clearance by antioxidant defences, mediates cellular pathology. Grewia Spp fruits are a source of bioactive compounds and have notable antioxidant activity. Although the antioxidant capacity of Grewia Spp has been studied, there is very limited evidence that links the antioxidant activities of Grewia bicolor and Grewia flava to the inhibition of free radical formation associated with damage in biological systems. Methods: This study evaluated the protective effects of Grewia bicolor and Grewia flava extracts against free radical-induced oxidative stress and the resulting cytotoxicity effect using HeLa cells. Antioxidant properties determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and total phenolic content (TPC) assays showed significantly higher (p < 0.05) antioxidant activity in Grewia flava (ethanol extract) than Grewia flava (water extract) and Grewia bicolor (ethanol and water extracts). Results: Using 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide or MTT assay, cytotoxicity results showed that extracts of Grewia bicolor and Grewia flava were less toxic to HeLa cells at tested concentrations compared to the untreated control. This confirmed the low toxicity of these edible fruits at the tested concentrations in HeLa cells. Furthermore, hydrogen peroxide (H 2 O 2 )-induced cell loss was effectively reduced by pre-incubating HeLa cells with Grewia bicolor and Grewia flava extracts, with Grewia flava (ethanol extract) revealing better protection. Conclusion:The effect was speculated to be associated with the higher antioxidant activity of Grewia flava (ethanol extract). Additional studies will warrant confirmation of the mechanism of action of such effects.

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Glycosylated β-lipoprotein, Diabetes Mellitus and Atherosclerosis

Cited by 4 publications

References 4 publications

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats

Potential of Cydonia oblonga leaves in cardiovascular disease.

Antioxidant, Cytotoxicity and Cytoprotective Potential of Extracts ofGrewia FlavaandGrewia BicolorBerries

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