Glycosides of marine invertebrates—I. A comparative study of the glycoside fractions of pacific sea cucumbers

Elyakov, G. B.; Stonik, V. A.; Levina, E. V.; Slanke, V.P.; Кузнецова, Т. А.; Levin, V. S.

doi:10.1016/0305-0491(73)90005-9

Cited by 26 publications

(27 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The smallest number of saponins was observed in H. atra which enclosed a total of four sulfated congeners. Among these, two were already described in the literature for this species [4,11,30]. Contrary to some of these authors, however, we did not detect holothurins A and A 2 in H. atra.…”

Section: Discussioncontrasting

confidence: 98%

Qualitative and Quantitative Saponin Contents in Five Sea Cucumbers from the Indian Ocean

2010

View full text Add to dashboard Cite

To avoid predation, holothuroids produce feeding-deterrent molecules in their body wall and viscera, the so-called saponins. Five tropical sea cucumber species of the family Holothuriidae were investigated in order to study their saponin content in two different organs, the body wall and the Cuvierian tubules. Mass spectrometry techniques (MALDI- and ESI-MS) were used to detect and analyze saponins. The smallest number of saponins was observed in Holothuria atra, which contained a total of four congeners, followed by Holothuria leucospilota, Pearsonothuria graeffei and Actinopyga echinites with six, eight and ten congeners, respectively. Bohadschia subrubra revealed the highest saponin diversity (19 congeners). Saponin mixtures also varied between the two body compartments within a given animal. A semi-quantitative approach completed these results and showed that a high diversity of saponins is not particularly correlated to a high saponin concentration. Although the complexity of the saponin mixtures described makes the elucidation of their respective biological roles difficult, the comparisons between species and between body compartments give some clues about how these molecules may act as predator repellents.

show abstract

Section: Discussioncontrasting

confidence: 98%

Qualitative and Quantitative Saponin Contents in Five Sea Cucumbers from the Indian Ocean

2010

View full text Add to dashboard Cite

show abstract

“…The results indicate that the Cuvierian tubules contain a proportionally larger quantity of saponins than the body wall; although in terms of hemolytic activity, the two organs appear similar. Elyakov et al (Elyakov et al, 1973) and Kobayashi et al (Kobayashi et al, 1991) already reported high concentrations of saponins in the Cuvierian tubules, concentrations that were usually higher than those in the body wall (see also Van Dyck et al, 2010a). In the present study, body wall saponin extracts were tested at different concentrations on the fish C. julis and S. ocellatus in order to evaluate their overall toxicity.…”

Section: Discussionmentioning

confidence: 84%

The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish

Dyck

Caulier

Todesco

et al. 2011

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARYMore than 100 triterpene glycosides (saponins) have been characterized in holothuroids in the past several decades. In particular, Holothuria forskali contains 26 saponins in its Cuvierian tubules and 12 in its body wall. This high diversity could be linked to a chemical defense mechanism, the most commonly accepted biological role for these secondary metabolites. We performed an integrated study of the body-wall saponins of H. forskali. The saponins are mainly localized in the epidermis and in the mesothelium of the body wall and appear to be released when the holothuroid is stressed. Among the saponins present in the epidermis, one (holothurinoside G) was detected in the seawater surrounding non-stressed holothuroids and three others (holohurinosides C and F, and desholothurin A) were secreted when the animals were stressed. In addition, two new congeners (detected at m/z 1301 and 1317) were also present in the immediate surroundings of stressed holothuroids. These new saponins do not originate from the epidermis and could come from an internal organ. Quantities of secreted saponins were very low compared with the body wall and Cuvierian tubules concentrations. At natural concentrations, saponins do not represent a threat to the health of predatory fish. The deterrent effect of saponins seems therefore to act as an aposematic signal, warning potential predators of the unpalatability of the holothuroid tissues.

show abstract

“…Senyawa glikosida yang dapat larut dalam air ini menunjukkan aktivitas hemolitik dan sitotoksik baik in vivo maupun in vitro (Kelly, 2005). Beberapa senyawa saponin yang telah berhasil diisolasi dari teripang antara lain 24-dehydroholothurin A (Kobayashi et al, 1991;Jawahar et al, 2002), holothurin A (Dang et al, 2007;Jawahar et al, 2002), holothurin B (Elyakov et al, 1973;Jawahar et al, 2002). Holothurin A dan holothurin B juga telah berhasil diisolasi dari teripang A. miliaris (Elyakov et al, 1973;Jawahar et al, 2002).…”

Section: Analisis Komposisi Golonganunclassified

ANALYSIS OF SECONDARY METABOLITES, ANTIBACTERIAL ACTIVITY AND COMPOUND COMPOSITION IN THE SEA CUCUMBER Bohadschia sp. EXTRACT

Rasyid

2017

J. Ilmu dan Teknologi Kelautan Tropis

View full text Add to dashboard Cite

Bohadschia sp. is one of the sea cucumber species that has potential to be developed as a source of antibacterial from the sea. Samples of sea cucumber Bohadschia sp. used in this study collected from the Ratai bay waters, Lampung. This study aims to determine the type of secondary metabolites, antibacterial activity and compound composition analysis containing in the sea cucumber extract. Identification of secondary metabolites by observation of color reactions, precipitation and foam. The method used to antibacterial activity test was the agar diffusion method, while identification of the composition of compounds performed with Gas Chromatogaphy-Mass Spectroscopy (GC-MS) method.Top of FormThe results showed that the type of secondary metabolites contained in the extract of sea cucumber Bohadschia sp. were steroids and saponins. The extract of sea cucumber Bohadschia sp. showed antibacterial activity against Bacillus subtilis and Vibrio eltor. Results of GC-MS were 12 compounds and have a similarity index same or more than 90%. All compounds consist of organosilicon cyclic, fatty acid, steroid, cyclo alkene and alkena. The compound with biggest abundance was cholest-5-en-3-yl nonanoate (4.89%) and retention time was 37.370 minutes.

show abstract

Glycosides of marine invertebrates—I. A comparative study of the glycoside fractions of pacific sea cucumbers

Cited by 26 publications

References 6 publications

Qualitative and Quantitative Saponin Contents in Five Sea Cucumbers from the Indian Ocean

Qualitative and Quantitative Saponin Contents in Five Sea Cucumbers from the Indian Ocean

The triterpene glycosides of Holothuria forskali: usefulness and efficiency as a chemical defense mechanism against predatory fish

ANALYSIS OF SECONDARY METABOLITES, ANTIBACTERIAL ACTIVITY AND COMPOUND COMPOSITION IN THE SEA CUCUMBER Bohadschia sp. EXTRACT

Contact Info

Product

Resources

About