Glycosides from<i>Grewia damine</i>and<i>Filicium decipiens</i>

Jayasinghe, U. L. B.; Balasooriya, B A I S; Bandara, A.G.D.; Fujimoto, Yoshinori

doi:10.1080/14786410310001620538

Cited by 34 publications

(16 citation statements)

References 4 publications

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“…Compound f : Light green powder, UV absorption at 270 and 338 nm, deprotonated ion at m/z 431.0985 [M−H] − . Identified as apigenin 6- C -glucoside (isovitexin) [21,22].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Profile and Antidepressant Effect of Ormosia henryi Prain Leaf Ethanol Extract

Lü

Zhu

et al. 2019

IJMS

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The Ormosia henryi Prain leaf (OHPL) is a new bioactive resource with potential antidepressant activity, but few reports have confirmed its chemical composition or antidepressant effect. To investigate the phytochemical profile of OHPL ethanol extract (OHPLE), six flavone C-glycosides and two flavone O-glycosides were purified by high-speed counter-current chromatography combined with preparative high-performance liquid chromatography (HSCCC-prep-HPLC). The eight isolated compounds were identified by NMR and MS. Forty-six flavonoids, including flavones, flavone C-glycosides, flavone O-glycosides, isoflavones, isoflavone O-glycosides, prenylflavones and polymethoxyflavones were definitively or tentatively identified from OHPLE using ultra-performance liquid chromatography/ electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOF-MS/MS) on the basis of fragment ions that are characteristic of these isolated compounds. The results of the antidepressant assay suggest that OHPLE significantly improved depression-related behaviors of chronic unpredictable mild stress (CUMS) mice. The observed changes in these mice after OHPLE treatment were an increased sucrose preference index, reduced feeding latency, prolonged tail suspension time, and upregulated expression of brain-derived neurotrophic factor (BDNF). The details of the phytochemicals and the antidepressant effect of OHPLE are reported here for the first time. This study indicates that the OHPL, enriched in flavone C-glycosides, is a new resource that might be potentially applied in the field of nutraceuticals (or functional additives) with depression-regulating functions.

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“…Compound f : Light green powder, UV absorption at 270 and 338 nm, deprotonated ion at m/z 431.0985 [M−H] − . Identified as apigenin 6- C -glucoside (isovitexin) [21,22].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Profile and Antidepressant Effect of Ormosia henryi Prain Leaf Ethanol Extract

Lü

Zhu

et al. 2019

IJMS

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“…1 H-NMR (500 MHz, CD 3 OD) δ 8.06 (2H, d, J = 8.6 Hz,H-2’, 6’), 6.89 (2H, d, J = 8.6 Hz, H-3’, 5’), 6.43(1H, s, H-8), 6.19 (1H, s, H-6), 5.25 (1H, d, J = 7.2 Hz, H-1”), 3.71 (1H, dd, J = 11.9, 2.0 Hz, H-6a”), 3.55 (1H, dd, J = 12.0, 5.5 Hz, H-6b”), 3.29–3.46 (4H, m, H-2”, 3”, 4”, 5”). 13 C-NMR (125 MHz, CD 3 OD), shown in Table 1 [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant capacity of phenolics in Camellia nitidissima Chi flowers and their identification by HPLC Triple TOF MS/MS

Yang

Guan²,

Wang

et al. 2018

PLoS ONE

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Camellia nitidissima Chi (CNC) is a valuable medicinal and edible plant in China. In this study, CNC flowers were extracted with 95% ethanol, then partitioned into dichloromethane, ethyl acetate, n-butanol, and water fractions, with the antioxidant capacity of flavonoids and other phytochemicals in CNC flowers investigated for the first time. Results showed that the ethyl acetate fraction exhibited the strongest antioxidant capacity and highest total phenolic content (TPC) compared with the other fractions. Furthermore, in the ethyl acetate fraction, the 50% effective concentrations (EC50) of ABTS+ and DPPH radical scavenging activities were 64.24 ± 1.80 and 78.80 ± 0.34 μg/mL, respectively, and the ferric reducing antioxidant power (FRAP) was 801.49 ± 2.30 μM FeSO4 at 1,000 μg/mL. Pearson’s correlation coefficients and principal component analyses (PCA) for the TPC and antioxidant capacity of the five fractions indicated that the phenolic compounds were the major antioxidant constituents in the flowers. To exploit the antioxidants in CNC flowers, 21 phenolic compounds in the ethanolic extract fraction were identified by HPLC Triple TOF MS/MS, next, 12 flavonoids were isolated and elucidated, of which compounds 1–5 showed potent antioxidant capacity. In addition, the potential structure-activity relationship among these 12 flavonoids showed that (1) the o-catechol group in the B-ring was primarily responsible for the antioxidant capacity of flavonoids and (2) steric hindrance, produced by glycosides and other groups, could reduce the antioxidant capacity of the flavonoids.

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“…The latter was identified by HRMS, 1 H and 13 C NMR spectrometry and comparison with the literature (Ö zden et al, 1998). Acetylation of 18 mg of impure 2 in 0.5 ml of pyridine with 1 ml of Ac 2 O overnight followed by the usual work-up and HPLC (hexane-EtOAc 2:3, flow rate 2 ml min À1 ) furnished 8 mg of isoquercitrin octaacetate (2a), T R 21 min, and 3 mg of rutin decaacetate (7), both identified by MS, 1 H and 13 C NMR spectrometry (Demetzos et al, 1989;Jayasinghe et al, 2004).…”

Section: Extraction and Isolation Of The Flavonoidsmentioning

confidence: 99%