2022
DOI: 10.1039/d1fo04170c
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Glycosides and flavonoids from the extract of Pueraria thomsonii Benth leaf alleviate type 2 diabetes in high-fat diet plus streptozotocin-induced mice by modulating the gut microbiota

Abstract: Twenty glycoside derivatives and nine flavonoids from the leaves of Pueraria (P. thomsonii) were isolated by column chromatography and characterized by nuclear magnetic resonance spectroscopy (NMR) and high performance liquid...

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Cited by 25 publications
(19 citation statements)
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“…The IC 50 value of 0.506 ± 0.001 mM for compound AF−15 (kaempferol−4’,7−dimethyl−3−O−glucoside), in which the two hydroxyl hydrogens at the 4’ and 7 positions were substituted with methyl groups and the hydroxyl hydrogens at the 3 position was substituted with glucose groups, which had the smallest IC 50 among the 12 flavonoids indicating that the α−glucosidase inhibitory activity of AF−15 was the lowest among these 12 flavonoids. The above results suggested that the reduction of phenolic hydroxyl groups in the B and C rings of the flavonoid backbone and the occurrence of glucosyl substitution led to the reduction of α−glucosidase inhibitory activity, which was consistent with the results of previous studies [ 24 , 26 ].…”
Section: Resultssupporting
confidence: 92%
See 1 more Smart Citation
“…The IC 50 value of 0.506 ± 0.001 mM for compound AF−15 (kaempferol−4’,7−dimethyl−3−O−glucoside), in which the two hydroxyl hydrogens at the 4’ and 7 positions were substituted with methyl groups and the hydroxyl hydrogens at the 3 position was substituted with glucose groups, which had the smallest IC 50 among the 12 flavonoids indicating that the α−glucosidase inhibitory activity of AF−15 was the lowest among these 12 flavonoids. The above results suggested that the reduction of phenolic hydroxyl groups in the B and C rings of the flavonoid backbone and the occurrence of glucosyl substitution led to the reduction of α−glucosidase inhibitory activity, which was consistent with the results of previous studies [ 24 , 26 ].…”
Section: Resultssupporting
confidence: 92%
“…The α−glucosidase inhibitory activity assay method of A. tenuissimum flower flavonoids was slightly modified based on previous studies [ 22 , 23 , 24 ]. A 96−well plate was used for preparing the mixture consisting of 0.1 M PBS (pH 6.8), 1.0 mg/mL sample solution, and 2 U/mL α−glucosidase, which were incubated at 37 °C for 10 min.…”
Section: Methodsmentioning
confidence: 99%
“… 35 Pueraria lobata extract improved glucose and lipid metabolism and inflammation by regulating GM and treating T2DM. 36 HAW1-2 in hawthorn directly altered the intestinal microflora (particularly Bacteroides ) and produced SCFAs. 37 Eucommia ulmoides balanced the structure and composition of intestinal microflora and improved intestinal tissue morphology.…”
Section: Discussionmentioning
confidence: 99%
“…The gut microbiota play essential roles in the digestion and absorption of flavonoids and affect the occurrence and progression of T2DM. Flavonoids effectively increased insulin levels, decreased FBG content, reduced lipid accumulation in plasma, alleviated oxidative injury and inflammation, and relieved liver and kidney damage in diabetic mice ( 50 ). For example, Pueraria extract contains nine flavonoids; they can increase intestinal probiotics to improve metabolic disorders caused by diabetes and decrease Clostridium celatum levels to alleviate inflammation.…”
Section: Effects Of Chinese Herb Ingredients On Intestinal Microbiotamentioning
confidence: 99%
“…For example, Pueraria extract contains nine flavonoids; they can increase intestinal probiotics to improve metabolic disorders caused by diabetes and decrease Clostridium celatum levels to alleviate inflammation. Flavonoids have the potential to be used to control type 2 diabetes by regulating glycolipid metabolism and inflammation levels ( 50 , 51 ).…”
Section: Effects Of Chinese Herb Ingredients On Intestinal Microbiotamentioning
confidence: 99%