Glycosaminoglycans in human skin

Lis, J.M.J.; Kruiswijk, T.; Mager, Willem H.; Kalsbeek, G.L.

doi:10.1111/j.1365-2133.1973.tb07565.x

Cited by 13 publications

(4 citation statements)

References 16 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is featured alongside mesenchymal cell proliferation, angiogenesis, and epithelialization. Fibroblasts infiltrate at 48–72 h after wounding, leading to granulation formation [ 42 ]. The proliferation is stimulated by PDGF, TGFb, and basic FGF [ 42 ].…”

Section: Vocal Fold Wound Healing and Scarringmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Oxidative Stress on the Human Voice

Hirano,

Inufusa,

You

2024

IJMS

View full text Add to dashboard Cite

The vocal fold vibrates in high frequency to create voice sound. The vocal fold has a sophisticated histological “layered structure” that enables such vibration. As the vibration causes fricative damage to the mucosa, excessive voicing can cause inflammation or injury to the mucosa. Chronic inflammation or repeated injury to the vocal fold occasionally induces scar formation in the mucosa, which can result in severe dysphonia, which is difficult to treat. Oxidative stress has been proven to be an important factor in aggravating the injury, which can lead to scarring. It is important to avoid excessive oxidative stress during the wound healing period. Excessive accumulation of reactive oxygen species (ROS) has been found in the injured vocal folds of rats during the early phase of wound healing. Antioxidants proved to be useful in preventing the accumulation of ROS during the period with less scar formation in the long-term results. Oxidative stress is also revealed to contribute to aging of the vocal fold, in which the mucosa becomes thin and stiff with a reduction in vibratory capacity. The aged voice can be characterized as weak and breathy. It has been confirmed that ROS gradually increases in rat vocal fold mucosa with age, which may cause further damage to the vocal fold. Antioxidants have also proved effective in avoiding aging of the vocal fold in rat models. Recently, human trials have shown significant effects of the antioxidant Twendee X for maintaining the voice of professional opera singers. In conclusion, it is suggested that oxidative stress has a great impact on the damage or deterioration of the vocal folds, and the use of antioxidants is effective for preventing damage of the vocal fold and maintaining the voice.

show abstract

Section: Vocal Fold Wound Healing and Scarringmentioning

confidence: 99%

“…Fibroblasts infiltrate at 48–72 h after wounding, leading to granulation formation [ 42 ]. The proliferation is stimulated by PDGF, TGFb, and basic FGF [ 42 ]. Fibroblasts begin to produce many ECM components including collage type I, III, elastin, fibronectin, and GAGs to repair the wounded tissues.…”

Section: Vocal Fold Wound Healing and Scarringmentioning

confidence: 99%

The Effect of Oxidative Stress on the Human Voice

Hirano,

Inufusa,

You

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…42 Hyaluronic acid is the major GAG of adult human skin. 43 It is also one of the most abundant components in the ECM of the dermis, more than 50% of total HA in the body is present in skin. 39 Hyaluronic acid is an unbranched polysaccharide composed of repeating disaccharides of d -glucuronic and N-acetyl- d -glucosamine.…”

Section: Extracellular Matrix Components and Functions In Normal Skinmentioning

confidence: 99%

The Role of Extracellular Matrix in Wound Healing

Lin

Zhang

2023

Dermatol Surg

View full text Add to dashboard Cite

BACKGROUND Extracellular matrix communicates with surrounding cells to maintain skin homeostasis and modulate multiple cellular processes including wound healing. OBJECTIVE To elucidate the dynamic composition and potential roles of extracellular matrix in normal skin, wound healing process, and abnormal skin scarring. MATERIALS AND METHODS Literature review was performed to identify relevant publications pertaining to the extracellular matrix deposition in normal skin and wound healing process, as well as in abnormal scars. RESULTS A summary of the matrix components in normal skin is presented. Their primary roles in hemostasis, inflammation, proliferation, and remodeling phases of wound healing are briefly discussed. Identification of novel extracellular matrix in keloids is also provided. CONCLUSION Abnormal scarring remains a challenging condition with unmet satisfactory treatments. Illumination of extracellular matrix composition and functions in wound healing process will allow for the development of targeted therapies in the future.

show abstract

“…These GAGs substantially contribute to the ability of skin to retain water, thereby preserving its volume and elasticity. [ 13 ] After skin injury, the body quickly initiates the regeneration and repair processes. Any destruction or prolongation at any stage may hinder wound healing.…”

Section: Innate Roles Of Gags In Wound Healingmentioning

confidence: 99%

Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

Yang,

Lu,

Gou

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Glycosaminoglycans (GAGs) are important for the occurrence of signaling molecules and maintenance of microenvironment within the extracellular matrix (ECM) in living tissues. GAGs and GAG‐based biomaterial approaches have been widely explored to promote in situ tissue regeneration and repair by regulating the wound microenvironment, accelerating re‐epithelialization, and controlling ECM remodeling. However, most approaches remain unacceptable for clinical applications. To improve insights into material design and clinical translational applications, this review highlights the innate roles and bioactive mechanisms of native GAGs during in situ wound healing and presents common GAG‐based biomaterials and the adaptability of application scenarios in facilitating wound healing. Furthermore, challenges before the widespread commercialization of GAG‐based biomaterials are shared, to ensure that future designed and constructed GAG‐based artificial biomaterials are more likely to recapitulate the unique and tissue‐specific profile of native GAG expression in human tissues. This review provides a more explicit and clear selection guide for researchers designing biomimetic materials, which will resemble or exceed their natural counterparts in certain functions, thereby suiting for specific environments or therapeutic goals.

show abstract

Glycosaminoglycans in human skin

Cited by 13 publications

References 16 publications

The Effect of Oxidative Stress on the Human Voice

The Effect of Oxidative Stress on the Human Voice

The Role of Extracellular Matrix in Wound Healing

Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials

Contact Info

Product

Resources

About