Glycoprotein contributions to mammary gland and mammary tumor structure and function: Roles of adherens junctions, ErbBs and membrane MUCs

Carraway, Kermit L.; Palau, Victoria; Carraway, Coralie A. Carothers

doi:10.1002/jcb.20612

Cited by 26 publications

(17 citation statements)

References 49 publications

(58 reference statements)

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“…It is present in about 90 % of breast cancers; its expression was also significant (p<0.05) in this study. It has been reported that Erbs can bind to the cytoplasmic tail of MUC1 [13]. This relation was also observed in this study since ErbB-2 expression marker was significant (p00.024) [30].…”

Section: Discussionsupporting

confidence: 88%

“…The discovery of the overexpression of ErbB2/HER2/Neu in about 25 % of breast cancers has been focused attention on the ErbB family of receptor tyrosine kinases as a significant contributor to tumor progression. ErbB2 is recognized as an important contributor to some types of breast cancer [13]. Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Markers in Peripheral Blood of Iranian Women with Breast Cancer

Oloomi

Bouzari

Mohagheghi

et al. 2012

Cancer Microenvironment

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A biomarker is a quantifiable laboratory measure of a disease specific biologically relevant molecule that can act as an indicator of a current or future disease state. The purpose of this study is to detect the expression of RNA biomarkers using Cytokeratin 19 (CK-19), Mammaglobin (MAM), Carcinoembryonic antigen (CEA), Mucin (MUC), C-Myc, erb-B2, a proliferation marker (Ki-67), Epidermal growth factor receptor (Her2/neu) and Estrogen receptor (ER) in Iranian women who were diagnosed with breast cancer. In this study, 90 samples; 60 cancer patients and 30 healthy controls were considered. 73.4 % patients were in stage I/II and 26.6 % were in stage III/IV. Patients were selected prior to the administration of any adjuvant systemic therapy. Total RNA extraction was obtained from peripheral blood of each patient and healthy control. Reverse transcription polymerase chain reaction (RT-PCR) method was used for detection of mRNA of the selected biomarkers of circulating breast cancer cells in blood. Molecular characterization is assessed as a method for early detection of breast cancer. For this purpose, eleven specific primers were selected and RT-PCR was used. The data of RT-PCR revealed that expression of MUC1, CK19, CEA, MAM, erbB-2, Ki67 and C-Myc biomarkers were significantly different between breast cancer patients and healthy controls. On the other hand, ERα, ERβ and Her2 markers were not significantly different between the two mentioned groups.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Molecular Markers in Peripheral Blood of Iranian Women with Breast Cancer

Oloomi

Bouzari

Mohagheghi

et al. 2012

Cancer Microenvironment

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“…It is worth noting that cell-cell junctions, which establish and maintain epithelium three-dimensional organization, are essential to proper MEC function. In fact, these complexes have essential contributions both to tissue structure and to cell signaling since they are structural elements involved in stabilizing the cell layer and providing the permeability barrier between the epithelial lumen and the underlying stroma (Carraway et al, 2005). Thus, the downregulation of FER and FYN observed in Defective CSN1S1 genotype goats suggests a stronger cell-cell interaction that could be linked to MEC function modification (Figure 4).…”

Section: Resultsmentioning

confidence: 99%

Goat’s αS1-casein polymorphism affects gene expression profile of lactating mammary gland

Ollier

Chauvet

Martin³

et al. 2008

Animal

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Goat's a S1 -casein (CSN1S1) polymorphism has a significant effect on milk protein and lipid composition, which affects the nutritional quality and technological properties of milk. Moreover, this polymorphism has a large impact on the morphology of mammary epithelial cells. To explore the metabolic pathways modulated in relation to this polymorphism, we compared the mammary gene expression profiles of two groups of lactating goats carrying either two reference or two defective alleles, using a bovine oligonucleotide microarray representing 8379 genes. We identified 41 differentially expressed genes between the two genotype groups. In particular, we showed a downregulation of two key lipogenic genes encoding fatty acid synthase and glycerol-3-phosphate acyltransferase in agreement with the low fat concentration associated with CSN1S1 deficiency. In addition, this study highlights changes in the expression level of several genes known to influence membrane fluidity, cell-cell interaction or chromatin organization. Our results open up new fields of investigation on structural modifications associated with CSN1S1 deficiency that could affect mammary gland function.

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“…Among these, β-integrins, 3 MUC-4 4 and CD44 5 are probably the best known candidates whose roles in cancer progression are well documented. 3,6,7 ErbB2 is embedded into this network of signaling and accessory molecules and by its promiscuous association profile it promotes cancer progression. 8 CD44 is recognized as the major hyaluronan receptor having several, alternatively spliced isoforms varying in their physiological function.…”

Section: Introductionmentioning

confidence: 99%