Glycolysis-based drug delivery nanosystems for therapeutic use in tumors and applications

Geng, Chenchen; Pang, Siyan; Ye, R.; Shi, Jun; Yang, Qingling; Chen, Changjie; Wang, Wenrui

doi:10.1016/j.biopha.2023.115009

Cited by 4 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This demonstrates the importance of nanomedicines targeting the glycolytic mechanisms. In a recent paper by Geng et al [ 164 ], the targeting of glycolytic enzymes and transporters, and combinational strategies based on nanomedicines were reviewed. Also, glucose metabolism in hypoxic tumor sites highly activates cancer stem cell (CSCs) phenotypes, and this promotes the activation of a stem-like polarization that is mainly regulated by the transcription factor HIF-1α and the Notch pathways [ 165 ].…”

Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

View full text Add to dashboard Cite

Solid tumors are composed of a highly complex and heterogenic microenvironment, with increasing metabolic status. This environment plays a crucial role in the clinical therapeutic outcome of conventional treatments and innovative antitumor nanomedicines. Scientists have devoted great efforts to conquering the challenges of the tumor microenvironment (TME), in respect of effective drug accumulation and activity at the tumor site. The main focus is to overcome the obstacles of abnormal vasculature, dense stroma, extracellular matrix, hypoxia, and pH gradient acidosis. In this endeavor, nanomedicines that are targeting distinct features of TME have flourished; these aim to increase site specificity and achieve deep tumor penetration. Recently, research efforts have focused on the immune reprograming of TME in order to promote suppression of cancer stem cells and prevention of metastasis. Thereby, several nanomedicine therapeutics which have shown promise in preclinical studies have entered clinical trials or are already in clinical practice. Various novel strategies were employed in preclinical studies and clinical trials. Among them, nanomedicines based on biomaterials show great promise in improving the therapeutic efficacy, reducing side effects, and promoting synergistic activity for TME responsive targeting. In this review, we focused on the targeting mechanisms of nanomedicines in response to the microenvironment of solid tumors. We describe responsive nanomedicines which take advantage of biomaterials’ properties to exploit the features of TME or overcome the obstacles posed by TME. The development of such systems has significantly advanced the application of biomaterials in combinational therapies and in immunotherapies for improved anticancer effectiveness.

show abstract

Section: Nanomedicines For Targeting Tme: Application Of Natural and ...mentioning

confidence: 99%

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Avgoustakis,

Angelopoulou

2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

Construction and performance evaluation of pH-responsive oxidized hyaluronic acid hollow mesoporous silica nanoparticles

Enyu,

Xinbo,

Xuelian

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Mu,

Zhang,

Zhou

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Glycolysis-based drug delivery nanosystems for therapeutic use in tumors and applications

Cited by 4 publications

References 73 publications

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Biomaterial-Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironments

Construction and performance evaluation of pH-responsive oxidized hyaluronic acid hollow mesoporous silica nanoparticles

Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Contact Info

Product

Resources

About