Construction and performance evaluation of pH-responsive oxidized hyaluronic acid hollow mesoporous silica nanoparticles

Enyu, Xu; Xinbo, Liu; Xuelian, Chen; Huimin, Chen; Yin, Chen; Yan, Chen

doi:10.1016/j.ijbiomac.2023.128656

Cited by 3 publications

(1 citation statement)

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“…Within this nanoplatform, CuMSNs functioned as nanocarriers, creating a microenvironment rich in Cu 2+ . Additionally, the release results of DSF also include the reasons for the premature leakage of DSF from DSF@CuMSN-PDA before it reaches and accumulates at the designated target sites within the circulatory system [ 53 , 54 ].…”

Section: Resultsmentioning

confidence: 99%

Polydopamine-Modified Copper Coordination Mesoporous Silica Nanoparticles Loaded with Disulfiram for Synergistic Chemo-Photothermal Therapy

Ling,

Cai,

Feng

et al. 2024

Pharmaceutics

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Disulfiram (DSF) degrades to diethyldithiocarbamate (DTC) in vivo and coordinates with copper ions to form CuET, which has higher antitumor activity. In this study, DSF@CuMSN-PDA nanoparticles were prepared using mesoporous silica with copper ions, DSF as a carrier, and polydopamine (PDA) as a gate system. The nanoparticles selectively released CuET into tumor tissue by taking advantage of the tumor microenvironment, where PDA could be degraded. The release ratio reached 79.17% at pH 5.0, indicating pH-responsive drug release from the nanoparticles. The PDA-gated system provided the nanoparticles with unique photothermal conversion performance and significantly improved antitumor efficiency. In vivo, antitumor experiments showed that the designed DSF@CuMSN-PDA nanoparticles combined with near-infrared light (808 nm, 1 W/cm2) irradiation effectively inhibited tumor growth in HCT116 cells by harnessing the combined potential of chemotherapy and photothermal therapy; a synergistic effect was achieved. Taken together, these results suggest that the designed DSF@CuMSN-PDA construct can be employed as a promising candidate for combined chemo-photothermal therapy.

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Section: Resultsmentioning

confidence: 99%