Glycoglycerolipids Isolated from Marine Derived<i>Streptomyces coelescens</i>PK206-15

Cho, Ji Young

doi:10.1271/bbb.120354

Cited by 6 publications

(6 citation statements)

References 37 publications

(38 reference statements)

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“…FX-58 is associated with marine plant Salicornia herbacea [178]. Glycoglycerolipids (332-335) (Figure 20) produced by Streptomyces coelescens PK206-15 derived from brown algae Laminaria japonica rhizosphere were active against the following fouling animals and plants: zoospores of Ulva pertusa, the diatom Navicula annexa, the mussel Mytilus edulis and fouling bacteria with an EC 50 range of 0.005-0.2 µg/mL [180].…”

Section: Other Structure Classesmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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The actinomycetes have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. With interactions of host organisms and having special ecological status, the actinomycetes associated with marine animals, marine plants, macroalgae, cyanobacteria, and lichens have more potential to produce active metabolites acting as chemical defenses to protect the host from predators as well as microbial infection. This review focuses on 536 secondary metabolites (SMs) from actinomycetes associated with these marine organisms covering the literature to mid-2021, which will highlight the taxonomic diversity of actinomycetes and the structural classes, biological activities of SMs. Among all the actinomycetes listed, members of Streptomyces (68%), Micromonospora (6%), and Nocardiopsis (3%) are dominant producers of secondary metabolites. Additionally, alkaloids (37%), polyketides (33%), and peptides (15%) comprise the largest proportion of natural products with mostly antimicrobial activity and cytotoxicity. Furthermore, the data analysis and clinical information of SMs have been summarized in this article, suggesting that some of these actinomycetes with multiple host organisms deserve more attention to their special ecological status and genetic factors.

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Section: Other Structure Classesmentioning

confidence: 99%

Natural Products from Actinomycetes Associated with Marine Organisms

Chen

Zhou

et al. 2021

Marine Drugs

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“…Its crude extracts showed anti-fouling activity against Ulva pertusa zoospore settlement with EC50 < 5 mg/mL. Four glycoglycerolipids (25-28) (Figure 3) were obtained from its crude extract, and they were active against the zoospores of U. pertusa, the mussel Mytilus edulis, the diatom Navicula annexa, and fouling bacteria, with an EC50 ranging from 0.005 to 0.2 µg/mL [54]. Streptomyces praecox 291-11 was isolated from seaweed brown algae Undaria pinnatifida rhizosphere, collected from a 10 m depth along the coast of Korea.…”

Section: Bioactive Metabolites From Streptomycesmentioning

confidence: 99%

Natural Products and Biological Activity from Actinomycetes Associated with Marine Algae

et al. 2023

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Marine natural products have been recognized as the most promising source of bioactive substances for drug discovery research. This review illustrates the diversity of culturable actinobacteria associated with marine algae, their bioactivity and metabolites, and approaches to their isolation and determination of their biological properties. Furthermore, actinobacteria associated with marine algae are presented as a new subject for an extensive investigation to find novel and active natural products, which make them a potentially rich and innovative source for new drug development deserving more attention and exploration.

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“…A comprehensive bibliographic search was conducted on antibiofilm and antifouling natural products from actinomycetes (Xu et al, 2007;Xu et al, 2010;Selvin, 2009;Cho, 2012;Prakash et al, 2015;Gopikrishnan et al, 2016;Waturangi et al, 2017;Kavitha and Vimala, 2020;Pereira et al, 2020;She et al, 2022;Stalin et al, 2022). Surprisingly, the reported studies referred to Streptomyces, with only one exception.…”

mentioning

confidence: 99%

“…Among actinomycetes, the Streptomyces genus has proven particularly prolific in producing antifouling agents. The chemical groups of these compounds encompass terpenoids, polyketides, furanones, butenolides, glycoglycerolipids, and alkaloids (Xu et al, 2010;Cho, 2012;Morgan et al, 2023).…”

mentioning

confidence: 99%

“…For instance, Streptomyces praecox 291-11, isolated from Undaria pinnatifida rhizosphere, produced diketopiperazines with antifouling activity against Ulva pertusa and Navicula annexa . Streptomyces coelescens PK206-15, associated with seaweed, produced glycoglycerolipids inhibiting various fouling organisms (Cho, 2012). Streptomyces cinnabarinus PK209, co-cultured with Alteromonas sp.…”

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confidence: 99%

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Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents

Wissner,

Almeida,

Grilo

et al. 2024

Front. Chem.

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Introduction: Biofouling poses a significant economic threat to various marine industries, leading to financial losses that can reach billions of euros annually. This study highlights the urgent need for effective alternatives to traditional antifouling agents, particularly following the global ban on organotin compounds.Material and methods:Streptomyces aculeolatus PTM-346 was isolated from sediment samples on the shores of the Madeira Archipelago, Portugal. The crude extract was fractionated using silica flash chromatography and preparative HPLC, resulting in two isolated marinone compounds: madeirone (1), a novel marinone derivative discovered in this study, and neomarinone (2). The antifouling activities of these compounds were tested against five marine bacterial species and the larvae of the mussel Mytilus galloprovincialis. Additionally, in silico and in vivo environmental toxicity evaluations of madeirone (1) and neomarinone (2) were conducted.Results: Madeirone (1) demonstrated significant antibiofilm efficacy, inhibiting Phaeobacter inhibens by up to 66%, Marinobacter hydrocarbonoclasticus by up to 60%, and Cobetia marina by up to 40%. Neomarinone (2) also exhibited substantial antibiofilm activity, with inhibition rates of up to 41% against P. inhibens, 40% against Pseudo-oceanicola batsensis, 56% against M. hydrocarbonoclasticus, 46% against C. marina, and 40% against Micrococcus luteus. The growth inhibition activity at the same concentrations of these compounds remained below 20% for the respective bacteria, highlighting their effectiveness as potent antibiofilm agents without significantly affecting bacterial viability. Additionally, both compounds showed potent effects against the settlement of Mytilus galloprovincialis larvae, with EC50 values of 1.76 µg/mL and 0.12 µg/mL for compounds (1) and (2), respectively, without impairing the viability of the targeted macrofouling species. In silico toxicity predictions and in vivo toxicity assays both support their potential for further development as antifouling agents.Conclusion: The newly discovered metabolite madeirone (1) and neomarinone (2) effectively inhibit both micro- and macrofouling. This distinct capability sets them apart from existing commercial antifouling agents and positions them as promising candidates for biofouling prevention. Consequently, these compounds represent a viable and environmentally friendly alternative for incorporation into paints, primers, varnishes, and sealants, offering significant advantages over traditional copper-based compounds.

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Glycoglycerolipids Isolated from Marine DerivedStreptomyces coelescensPK206-15

Cited by 6 publications

References 37 publications

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products from Actinomycetes Associated with Marine Organisms

Natural Products and Biological Activity from Actinomycetes Associated with Marine Algae

Novel metabolite madeirone and neomarinone extracted from Streptomyces aculeoletus as marine antibiofilm and antifouling agents

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