Glycodynamers: Fluorescent Dynamic Analogues of Polysaccharides

Ruff, Yves; Lehn, Jean‐Marie

doi:10.1002/anie.200703490

Cited by 103 publications

(68 citation statements)

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“…Binding of the mannosylated poly(amidoamine) to bacterial E. coli leads to fluorescence quenching, which allows for the detection of the bacterial species at 100 cfu/ml. Lehn and co-workers also coined the term Bglycodynamerst o describe polymers bearing oligosaccharides that demonstrate different fluorescent properties based on the constitution of the polymer that can be readily tuned through reversible reactions [109,110]. Thus, a small library of glycan-decorated hydrazides 29, 30 and aldehydes 31-33 were generated (Fig.…”

Section: Glycan Decorated Fluorescent Polymersmentioning

confidence: 98%

Fluorescently labelled glycans and their applications

Yan

Yalagala

Yan³

2015

Glycoconj J

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This review summarises the literature on the synthesis and applications of fluorescently labelled carbohydrates. Due to the sensitivity of fluorescent detection, this approach provides a useful tool to study processes involving glycans. A few general categories of labelling are presented, in situ labelling of carbohydrates with fluorophores, fluorescently labelled glycolipids, fluorogenic glycans, pre-formed fluorescent glycans for intracellular applications, glycan-decorated fluorescent polymers, fluorescent glyconanoparticles, and other functional fluorescent glycans.

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Section: Glycan Decorated Fluorescent Polymersmentioning

confidence: 98%

Fluorescently labelled glycans and their applications

Yan

Yalagala

Yan³

2015

Glycoconj J

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“…More recently, the Lehn group has reported the synthesis of dynamic polymers with oligosaccharides grafted to the main -chain [6] . These " glycodynamers " were found to be strongly fl uorescent.…”

Section: Fluorescent Sensorsmentioning

confidence: 99%

Analytical Applications of Dynamic Combinatorial Chemistry

Severin

2010

Dynamic Combinatorial Chemistry

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IntroductionThe basic concepts of selection experiments with dynamic combinatorial libraries ( DCL s) were articulated more than 10 years ago (see Chapter 1 ). Since then, a number of applications have emerged. This includes the discovery new enzyme inhibitors, receptors, and catalysts, as well as the synthesis of novel materials such as responsive gels and polymers (see Chapters 2 -5 ). A recent addition to the list of applications is the utilization of dynamic combinatorial chemistry ( DCC ) for analytical purposes. This chapter summarizes the main ideas and results in this area.The concentrations of the different members of a DCL depend on the physical and chemical environment of the respective system (pH, solvent, concentration of target molecules, etc.). The library composition is therefore a characteristic feature of the respective environment. If the DCL composition can be transduced into a signal output, it is possible to use the DCL as a sensor. Typically, DCLs are analyzed by nuclear magnetic resonance spectroscopy or high -performance liquid chromatography. For sensing purposes, however, faster and cheaper analysis methods such as fl uorescence or ultraviolet -visible ( UV -Vis ) spectroscopy are preferred. These techniques can be used if the DCL is composed of compounds with different color or fl uorescence properties (Figure 7.1 ).For a DCL sensor of this kind, the information about the analyte is distributed over the entire spectrum. The spectrum therefore represents a " fi ngerprint " of the analyte. To correlate the spectral changes with the analyte properties of interest (identity, quantity, purity), it is advantageous to use multivariate analyses techniques. In this regard, a DCL sensor is related to sensor arrays [1,2] . However, contrary to sensor arrays with independent sensor units, a DCL sensor is comprised of compounds that are connected by exchange reactions. Furthermore, the various sensors of an array have to be analyzed separately, whereas a single UV -Vis or fl uorescence measurement is suffi cient for a DCL sensor. Dynamic Combinatorial Chemistry. Edited by Joost N. H. Reek and Sijbren Otto

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“…Arabinose was functionalized with either an alkoxyamine and a masked aldehyde (A -B monomer approach) to give a directional homopolymer, or with two alkoxyamines or two (masked) aldehydes (A -A + B -B approach) to give an alternating copolymer without directional orientation of the monomers [35] . Alternatively, the carbohydrates can be side -chains of the polymer if they are appended to the main -chain exchanging monomer [25] .…”

Section: Reversible Covalent Chemistry In Polymersmentioning

confidence: 99%