Glycodendrimers and Their Derivatives as Potential Therapeutic Agents

Abstract

Ключевые слова: Гликоконъюгаты, гликодендримеры, гликотерапия, анти-адгезионные свойства, углеводы.

Efficient Synthesis of Muramic and Glucuronic Acid Glycodendrimers as Dengue Virus Antagonists

“…Glycoconjugates perform key important functions in many pathological processes, such as viral and bacterial infections, often regulated by carbohydrate–protein interactions. With mounting evidence that not only the molecular structure but also the valency and spatial organization of carbohydrate epitopes in glycoconjugates influence the specificity and avidity of their interactions with cognate receptors, glycodendrimers have increasingly served as a tool for probing the underlying mechanisms of these events . In addition, there has been much interest in using glycodendrimers mimetics of glycoconjugates found on cell membrane to control the presentation of carbohydrates in glycan microarrays, which have emerged as a powerful platform for interrogating ligand specificities of carbohydrate‐binding proteins –…”

Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity

“…Glycodendrimers are synthetic macromolecules that have been extensively used to mimic many structural and functional features of cell‐surface glycoconjugates, and they have become increasingly used in recent years as a tool to study carbohydrate–protein interactions, allowing the identification of key factors in these interactions. The molecular structure, valency and spatial organisation of carbohydrate epitopes in glycodendrimers are major determinants of specificity and avidity in carbohydrate–protein interactions [3b, c, 9b, 10, 105] …”

“…Within this framework, various types of synthetic polymers bearing sugar residues (multivalent glycostructures) have been described. Glycodendrimers, [3b, 5, 105] neoglycoproteins, [6] glycopolymers [7] and glyconanoparticles [8] represent the four major classes [9]…”

Synthesis of Dipeptide and Carbohydrate Ivermectin B1 Derivatives

“…Большинство из них используется для лечения различных инфекций вирусного и бактериального происхождения, [3] гельмин-тозов и грибковых поражений. [4] Кроме того, имеются данные о положительном влиянии дополнительных фармакофорных азотсодержащих фрагментов в молеку-лах макролидов на проявление или усиление противо-воспалительной, анальгетической, противовирусной, антимикробной и противоопухолевой, а также иммуно-модулирующей активности.…”