Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man

Cham, Bill E.; Meares, Heather M.

doi:10.1016/0304-3835(87)90081-4

Cited by 80 publications

(70 citation statements)

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“…These observations are in stark contrast to other well established anti-mitotic chemotherapy drugs that only kill cancer cells while they are dividing and also kill normal cells when they too are dividing [40][41][42][43][44][45][46][47][48].…”

Section: Kill Cancer Cells In Proliferative and Non-proliferative Stamentioning

confidence: 93%

“…At these high concentrations of BEC, no significant toxic effects were observed. Subsequently clinical trials using 10% of BEC in a cream formulation determined that this formulation was effective for the treatments of keratoses, BCCs and SCCs [46]. More recently clinical trials with Curaderm BEC5 containing 0.005% BEC showed impressive results when, even very large nonmelanoma skin cancers were treated [2,27,34,38,[41][42][43][44][54][55][56].…”

Section: Bec5 Are More Effective and Safer Than Other Well Establishementioning

confidence: 99%

“…Most recently studies were published whereby the huge benefit in terms of cosmetic outcomes of Curaderm BEC5 therapy was shown [2,9,27,29,38,56,57]. Figures 13-21 illustrate some examples of cosmetic outcomes of various skin cancer treatments with Curaderm BEC5 [2,9,24,26,27,29,30,34,37,38,41,42,46,54]. Health versus cosmetic outcomes with Curaderm BEC5 have additional benefits.…”

Section: Curaderm Bec5 Shows Superior Cosmetic Outcomes Compared Withmentioning

confidence: 99%

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Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Chase¹

2011

JCT

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Section: Kill Cancer Cells In Proliferative and Non-proliferative Stamentioning

confidence: 93%

Section: Bec5 Are More Effective and Safer Than Other Well Establishementioning

confidence: 99%

Section: Curaderm Bec5 Shows Superior Cosmetic Outcomes Compared Withmentioning

confidence: 99%

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Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Chase¹

2011

JCT

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“…In 1987 we were the first to report that the plant-derived glycoalkaloids solasodine glycosides (SGs), including solamargine (SM), solasonine (SS), mono-and diglycosides of solasodine, known as BEC [1], induced anticancer effects in cell culture [2], animals [3] and humans [4].…”

Section: The Discovery and Consequences Thereofmentioning

confidence: 99%

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies

Cham¹

2017

IJCM

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Cancer remains a major cause of mortality worldwide. Progresses have been made in the understanding of the molecular basis of cancer, cancer detection, and cancer treatment. Important strides by treating early-stage cancers have resulted in improved outcomes. Despite these achievements, mortality of cancer patients is high and still there is no cure. Some oncologists remain optimistic that cytotoxic chemotherapy will significantly improve cancer survival. However, notwithstanding the use of new and expensive single and more recently, combination drugs, the improvement of the response rates remains very low. In the United States, cancer death rates decreased by a mere 1.4% to 1.8% from 2004 to 2013. Compared to other serious diseases, the improvement of the cancer patient has been disappointingly lagging, and by far, most patients with advanced cancer eventually die of their disease. The need for improved cancer therapies is self-evident. This communication gives an overview of the overwhelming resurgence of solasodine and its glycosides in cancer therapy.

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“…The aqueous layer was partitioned between H 2 O and n-butanol (BuOH). The BuOH soluble fraction was then subjected to silica gel, Chromatorex octadecyl silica (ODS), and Diaion HP20 column chromatography and HPLC on ODS to afford 17 glycosides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Notesmentioning

confidence: 99%

Five New Steroidal Glycosides from the Stems of Solanum sodomaeum

Ono

Uenosono

Umaoka

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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NotesSolanum sodomaeum L. is a solanaceous plant native to the Libyan Desert. There exist reports on the antineoplastic activity of a mixture of glycoalkaloids extracted from the fruits of this plant against Sarcoma 180 in mice.1) Furthermore, it has been reported that a cream formulation containing purified glycoalkaloids isolated from the fruits was effective in the treatment of malignant human skin tumors; basal cell carcinomas, squamous cell carcinomas, and benign tumors; and keratoses and keratoacanthomas.2) Fruit constituents such as steroidal glycosides and pyrrole alkaloids were also studied. 3,4) In the preceding paper, we had reported the isolation and structural elucidation of eight steroidal glycosides obtained from the methanol (MeOH) extract of the underground parts of this plant. Additionally, we had reported on the antiproliferative activity of these eight steroidal glycosides against human promyelocytic leukemia (HL-60) cells.5) As a continuation to this study, we now describe the isolation and structural elucidation of 5 new steroidal glycosides obtained from the MeOH extract of the stems of S. sodomaeum L., along with 12 known glycosides. In the process, the structure of one of these glycosides was corrected.The MeOH extract of the stems of S. sodomaeum was suspended in H 2 O and extracted with ethyl acetate (EtOAc). The aqueous layer was partitioned between H 2 O and n-butanol (BuOH). The BuOH soluble fraction was then subjected to silica gel, Chromatorex octadecyl silica (ODS), and Diaion HP20 column chromatography and HPLC on ODS to afford 17 glycosides (1-17).Compounds 7-17 were identified as Pd (7), 5) abutiloside O (8), 5) solamargine (9), 5) solasonine (10), 6) sycophantine (11), 6) protodioscin (12), 5) anguivioside XV (13), 10) respectively, based on the comparison of their physical and spectral data with authentic samples or those already reported (Fig. 1), although NMR spectral data of 16 and 17 have not been reported in the literature.Compound 1, tentatively named solasodoside B, was obtained as an amorphous powder, exhibiting an [MϩNa] ϩ ion peak at m/z 969 in the positive FAB-MS. The molecular formula of 1 was determined to be C 45 H 70 O 21 by high-resolution (HR)-positive FAB-MS. The IR spectrum of 1 displayed strong absorption bands at 3415 cm Ϫ1 due to hydroxyl groups and at 1768 cm Ϫ1 due to g-lactone group. The Table 1. Thus, the planar structure of 1, a steroidal glycoside possessing one g-lactone ring between C-22 and C-16 and one tetraglycosyl group at C-3 of aglycone, could be determined. On acidic hydrolysis, 1 afforded L-rhamnose, D-xylose, and D-glucose, which were confirmed by optical rotation using chiral detection in HPLC analysis. The 1 H-and 13 C-NMR data of the sugar moiety and of the C-1-C-11 of the aglycone moiety of 1 were superimposable on those of 14, 5) indicating that the sugar chain attached to the b-hydroxyl group at C-3 of aglycone was identical to the sugar chain of 14. The stereochemistry at C-16, C-17, and C-20 of aglycone was defined on the bas...

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Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man

Cited by 80 publications

References 5 publications

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies

Five New Steroidal Glycosides from the Stems of Solanum sodomaeum

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Glycoalkaloids from Solanum sodomaeum are effective in the treatment of skin cancers in man

Cited by 80 publications

References 5 publications

Curaderm&lt;sup&gt;BEC5&lt;/sup&gt; for Skin Cancers, Is It? An Overview

Curaderm&lt;sup&gt;BEC5&lt;/sup&gt; for Skin Cancers, Is It? An Overview

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies

Five New Steroidal Glycosides from the Stems of Solanum sodomaeum

Contact Info

Product

Resources

About

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview