Glyceryl trinitrate spray in the management of painful diabetic neuropathy: A randomized double blind placebo controlled cross-over study

Agrawal, R P; Choudhary, Ramdev; Sharma, Poornima; Sharma, Saurabh; Beniwal, R.; Kaswan, K; Kochar, Dhanpat Kumar

doi:10.1016/j.diabres.2006.12.003

Cited by 50 publications

(19 citation statements)

References 27 publications

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“…Similarly, the EFNS cited the same study but also reported a study that used glyceryl trinitrate spray (class I) and determined treatment with nitrate derivatives is supported with Level A evidence based on these two studies 85 .…”

Section: Pain Management In Dnpmentioning

confidence: 88%

Diabetic neuropathy: clinical manifestations and current treatments

Callaghan¹,

Cheng²,

Stables³

et al. 2012

The Lancet Neurology

913

739

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Diabetic peripheral neuropathy is a prevalent, disabling condition. The most common manifestation is a distal symmetric polyneuropathy (DSP), but many patterns of nerve injury can occur. Currently, the only effective treatments are glucose control and pain management. While glucose control dramatically decreases the development of neuropathy in those with type 1 diabetes, the effect is likely much smaller in those with type 2 diabetes. High levels of evidence support the use of certain anticonvulsants and antidepressants for pain management in diabetic peripheral neuropathy. However, the lack of disease modifying therapies for diabetic DSP makes the identification of new modifiable risk factors essential. Intriguingly, growing evidence supports an association between metabolic syndrome components, including pre-diabetes, and neuropathy. Future studies are needed to further explore this relationship with implications for new treatments for this common disease.

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Section: Pain Management In Dnpmentioning

confidence: 88%

Diabetic neuropathy: clinical manifestations and current treatments

Callaghan¹,

Cheng²,

Stables³

et al. 2012

The Lancet Neurology

913

739

View full text Add to dashboard Cite

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“…NTG has thus been used extensively to model migraine in human subjects (13). Interestingly, in other settings NTG reduces pain, such as its common use in myocardial syndrome, and topical NTG can reduce pain in patients with reflex sympathetic dystrophy or diabetic neuropathy (14,15). …”

Section: Introductionmentioning

confidence: 99%

Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice

et al. 2009

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The association between the clinical use of nitroglycerin (NTG) and headache has led to the examination of NTG as a model trigger for migraine and related headache disorders, both in humans and laboratory animals. In this study in mice, we hypothesized that NTG could trigger behavioural and physiological responses that resemble a common manifestation of migraine in humans. We report that animals exhibit a dose-dependent and prolonged NTG-induced thermal and mechanical allodynia, starting 30–60 min after intraperitoneal injection of NTG at 5–10 mg/kg. NTG administration also induced Fos expression, an anatomical marker of neuronal activity in neurons of the trigeminal nucleus caudalis and cervical spinal cord dorsal horn, suggesting that enhanced nociceptive processing within the spinal cord contributes to the increased nociceptive behaviour. Moreover, sumatriptan, a drug with relative specificity for migraine, alleviated the NTG-induced allodynia. We also tested whether NTG reduces the threshold for cortical spreading depression (CSD), an event considered to be the physiological substrate of the migraine aura. We found that the threshold of CSD was unaffected by NTG, suggesting that NTG stimulates migraine mechanisms that are independent of the regulation of cortical excitability.

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“…Имеется единичное исследование [150], в котором показана эффективность ботулотоксина при боле-вом синдроме у больных ДПН. Недавно опубликованы дан-ные об эффективности дериватов нитратов [151] и нового класса препаратов: агонистов никотиновых рецепторов [152]. Описаны физиотерапевтические методы лечения ДПН -магнитотерапия, чрезкожная электрическая стиму-ляция нерва, лечебная гимнастика, бальнеотерапия, релак-сационная терапия, акупунктура.…”

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Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment

Нестерова¹,

Galkin²

2013

Neurology, Neuropsychiatry, Psychosomatics

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Glyceryl trinitrate spray in the management of painful diabetic neuropathy: A randomized double blind placebo controlled cross-over study

Cited by 50 publications

References 27 publications

Diabetic neuropathy: clinical manifestations and current treatments

Diabetic neuropathy: clinical manifestations and current treatments

Sumatriptan alleviates nitroglycerin-induced mechanical and thermal allodynia in mice

Diabetic polyneuropathy: pathogenesis, classification, clinical presentation, and treatment

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