Glycerol-dimethacrylate as alternative hydrophilic monomer for HEMA replacement in simplified adhesives

Neto, Vitaliano Gomes de Araújo; Nobre, Caio Felipe de Almeida; Paula, D M De; Souza, Lidiane Costa de; Silva, J.C.; Moreira, Maria Mônica Studart Mendes; Picanço, P R; Feitosa, Victor Pinheiro

doi:10.1016/j.jmbbm.2018.03.022

Cited by 21 publications

(14 citation statements)

References 26 publications

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“…Several studies specifically mention the effects of HEMA, identifying it as a key component in the toxic response . Cellular toxicity of HEMA has been identified by apoptosis or necrosis in human primary cells and by DNA damage; the possibility of systemic mutagenic effects has been raised …”

Section: Discussionmentioning

confidence: 99%

Allergic reaction from dental bonding material through nitrile gloves: Clinical case study and glove permeability testing

Sananez

Sanchez

Davis

et al. 2019

J Esthet Restor Dent

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Objective: This study examines monomer permeation of commercial dental adhesive through nitrile-based gloves, and correlates findings with clinical case studies of dental students having localized skin eruptions following resin placement on a gloved hand to manipulate composite.Methods: Three dental students self-reported presenting itchy, red skin lesions underneath the area where they placed uncured adhesive resin on a nitrile-gloved hand. Histories and cursory examinations were performed in the Department of Dermatology at The Medical College of Georgia. Infrared spectroscopic methods were used to determine permeation times of known monomer components of commercial adhesive material used through nitrile glove. Monomer permeation times were correlated with the time when the commercial adhesive first applied and penetrated through the glove.Results: Assessment by the dermatologist concluded that the reporting students had occupational contact dermatitis resulting from components of the adhesive permeating through the barrier glove. Permeation times of neat monomer components of the adhesive resin varied over a wide range, with lower molecular weight showing faster pass-through times. Spectroscopic interpretation indicated that the probable causative agent for the student's skin reaction was 2-hydroxyethyl methacrylate (HEMA).Conclusions: Probable correlation of the observed skin reaction sites was made with diffusion of HEMA in the uncured dental adhesive formulation through nitrile glove material.Clinical Significance: All measures to prevent skin contact with uncured methacrylate-based resin components should be taken, including avoidance of resin permeation through a gloved hand. Sensitization to one type of methacrylate can result in sensitization to other types of resins within this family, significantly impacting the careers of both dental auxiliaries as well as clinicians. K E Y W O R D Sallergy, dental adhesive, glove permeability, methacrylate, occupational contact dermatitis

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Section: Discussionmentioning

confidence: 99%

Allergic reaction from dental bonding material through nitrile gloves: Clinical case study and glove permeability testing

Sananez

Sanchez

Davis

et al. 2019

J Esthet Restor Dent

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“…With the help of the microscope, a laser beam generating an approximately 1 µm spot focused on the intertubular regions of the resin–dentine interface. The spectra were acquired in line scans and calculated using the following formula [43]:DC%=(1−RcuredRuncured)×100%,where R represents the ratio between the peak intensities at 1640 cm −1 and at 1610 cm −1 of the light-cured adhesive at the resin–dentine interface and uncured adhesive within the quartz capillary siphon, respectively.…”

Section: Methodsmentioning

confidence: 99%

The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinases in vitro in an etch-and-rinse adhesive system

Shan

Zhao

et al. 2019

R. Soc. open sci.

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The biomimetic remineralization of collagen fibrils has increased interest in restoring the demineralized dentine generated by dental caries. Carboxyl-terminated polyamidoamine dendrimers (PAMAM-COOH), hyperbranched polymeric macromolecules, can act as non-collagenous proteins to induce biomimetic remineralization on a dentine organic matrix. However, in vivo remineralization is an extremely time-consuming process; before complete remineralization, demineralized dentine collagen fibrils are susceptible to degradation by host-derived matrix metalloproteinases (MMPs). Therefore, we examined the effect of fourth-generation PAMAM-COOH (G4-PAMAM-COOH) on the collagenolytic activities of endogenous MMPs, the interaction between G4-PAMAM-COOH and demineralized dentine collagen and the influence of G4-PAMAM-COOH pre-treatment on resin–dentine bonding. G4-PAMAN-COOH not only inhibited exogenous soluble rhMMP9 but also hampered the proteolytic activities of dentine collagen-bound MMPs. Cooperated with the results of G4-PAMAM-COOH absorption and desorption, FTIR spectroscopy provided evidence for the exclusive electrostatic interaction rather than hydrogen or covalent bonding between G4-PAMAM-COOH and dentine collagen. Furthermore, G4-PAMAM-COOH pre-treatment showed no damage to resin–dentine bonding because it did not significantly decrease the elastic modulus of the demineralized dentine, degree of conversion, penetration of the adhesive into the dentinal tubules or ultimate tensile strength. Thus, G4-PAMAM-COOH can effectively inactivate MMPs, retard the enzymolysis of collagen by MMPs and scarcely influence the application of resin–dentine bonding.

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“…The degree of conversion of experimental and control composites was evaluated using a previous described protocol [14]. Briefly, three milligrams of each composite were analyzed using Raman Spectroscopy (Xplora, Horiba Jobin Yvon, Paris, France) with a HeNe laser using 3.2 mW power and 532 nm laser wavelength.…”

Section: Methodsmentioning

confidence: 99%

“…The samples’ dimensions were 0.5 mm in thickness, 1 mm in width, and 8 mm in length. The experiment was performed using a previously published protocol [14] according to ISO 4049:2009. The composites were inserted into the molds, a polyester strip was placed onto the composites, and the tip of the DB-685 LED (1100 mW/cm²; Dabi Atlante, Ribeirao Preto, Brazil) was placed on the top of the sample while the curing was realized for 40 s. The tip diameter (10 mm) covered the entire specimen, allowing a single activation for each sample.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Evaluation of Experimental Self-Adhesive Orthodontic Composites Used to Bond Ceramic Brackets

et al. 2019

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The aim of this study was to evaluate the degree of conversion (DC), flexural strength (FS), and shear bond strength (SBS) of ceramic brackets bonded to enamel with experimental self-adhesive orthodontic composites. Functional monomers 10-methacryloyloxy-decyl-dihydrogen-phosphate (MDP) and glycerol-dimethacrylate-phosphate (GDMA-P) were used in experimental composites. They were compared to the same composite without an acidic monomer (negative control) and with enamel acid-etching prior to adhesive application (positive control). DC was evaluated by Raman micro-spectroscopy. Flexural three-point bending testing was performed in a universal testing machine. Ceramic brackets were bonded to bovine enamel and SBS was evaluated before and after 2000 thermal-cycles. Fracture patterns were surveyed with manual removal with specific pliers and analyzed by SEM. Statistics was performed using ANOVA and Tukey’s test (p < 0.05). DC of the control composite was significantly higher (p < 0.001) than that of GDMA-P and MDP. FS showed no significant difference between composites (p = 0.451). Regarding adhesion, the positive control (8.47 ± 0.88 MPa) and MDP (7.07 ± 2.69 MPa) obtained higher overall results. The predominant fracture pattern of the positive control and MDP was mixed while it was adhesive for further groups. The MDP-containing orthodontic composite attained similar adhesion to a conventional three-step orthodontic bonding system, with a similar fracture pattern and mechanical properties. Nevertheless, the presence of acidic functional monomers reduced the DC.

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Glycerol-dimethacrylate as alternative hydrophilic monomer for HEMA replacement in simplified adhesives

Cited by 21 publications

References 26 publications

Allergic reaction from dental bonding material through nitrile gloves: Clinical case study and glove permeability testing

Allergic reaction from dental bonding material through nitrile gloves: Clinical case study and glove permeability testing

The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinases in vitro in an etch-and-rinse adhesive system

In Vitro Evaluation of Experimental Self-Adhesive Orthodontic Composites Used to Bond Ceramic Brackets

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