Glycerol as a biodegradable and reusable promoting medium for the catalyst-free one-pot three component synthesis of 4H-pyrans

Synthesis and Biological Evaluation of some Novel Pyrano[2,3-<i>d</i>]Pyrimidine Derivatives

“…As a result, a number of reports have appeared in the literature that usually requires forcing conditions, long reaction times and complex synthetic pathways. Pyrano [2,3-d]pyrimidine synthesis was reported under various conditions such as microwave irradiation [15] and [16], ultrasonic irradiation [17], solvent free condition and in aqueous medium in the absence of catalysts [18].…”

Glycerol

“…6 Besides, glycerol is also widely used in organic synthesis because it dissolves inorganic salts, acids, bases, many transition-metal complexes, and enzymes. 7 It is also used in other fields, such as protein crystallization, 8 cosmetics, pharmaceutical formulations, and foodstuffs. 9…”

Incredible Role of Glycerol in Multicomponent Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones and 1-Amidoalkyl-2-naphthols

“…5 Also 2,3-Dihydroquinazolinone derivatives are an important class of fused heterocycles that display a wide range of biological, pharmacological, and medicinal properties involving antitumor, antibiotic, antipyretic, analgesic, antihypertonic, diuretic, antihistamine, antidepressant, and vasodilating activities. 6 The preparation of 1-amidoalkyl-2-naphthols can be carried out by the condensation of aryl aldehydes, 2-naphthol and acetonitrile or amide in the presence of Lewis or Brønsted acid catalysts 7 such as K-10 clay, 8 Ce(SO4)2, 9 iodine, 10 K5CoW12O40• 3H2O, 11 p-TSA, 12 sulfamic acid, 13 cation-exchanged resins, 14 silica-sulfuric acid, 15 silica supported dual acidic ionic liquid,…”

“…Furthermore, it also dissolves organic compounds that are poorly miscible in water, many hydrophobic solvents, such as ethers and hydrocarbons, are immiscible in glycerol. 8 In this context, glycerol has a clear advantage compared with most organic solvents. Indeed, glycerol is a nontoxic, biodegradable and nonflammable solvent for which no special handling precautions or storage is required.…”