Glycerol

Abstract

This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research spotlight Glycerol Compiled by Bin YuBin Yu was born in 1986 in Henan province, P. R. of China. He graduated from Zhengzhou University in 2012, obtaining a M.Sc. degree in pharmaceutical engineering. He is currently pursuing his Ph.D., majoring in medicinal chemistry under the supervision of Prof. Hong-Min Liu and Prof. De-Quan Yu at the same university. His research focuses on the discovery of novel small molecules with important properties using modern synthetic strategies.

Construction of Carbocycles from Methylenecyclopropanes

“…(30)]. [39] In 2009, we discovered another method to generate PhSe + + cations via the Lewis acid (LA: TiCl 4 ,A lCl 3 , FeCl 3 ,e tc. This PhSe radical was then converted into PhSe + + by the SET catalyst Cu(OAc) 2 ·H 2 Ow hich reactedw ith MCPs to produce the phenylselenylcyclobutenes 76 [Eq.…”

“…[34i,46c] In addition to CB structures,o xidative ring-expansion reactions of MCPs could be used to synthesize cyclobutanones,w hich are known as ac lass of very useful building blocks in drug development. (38)]. (36)].…”

“…[47] In 2006, Huang et al found that the oxidative ring-expansionr eactions of MCPs 1 with CAN as oxidant also led to 2-substituted cyclobutanones. (39)]. [48] Althought he abovem ethods leadt oc onvenient accesses to the useful 2-substituted cyclobutanones that are otherwise difficult to obtain, the use of chemical oxidants may leadt ot he generation of organic or inorganic wastes.T hus,t hese low atom economic reactions are not favorable for large-scale synthesis from the industrial viewpoint.…”

“…(29)]. [38] Obviously, the EtOH solvent participated in the reactiona saalcoholysisr eagent to decompose the PhSeO À Ci ntermediatea nd generate the related alcohol product 78. Ther eactionw as performed under mild conditions using visible light as the drivingforce.…”

“…(30)]. [39] In the reaction, homo-cleavage of the Se À Se bondo f( PhSe) 2 led to the PhSe radical under visible light irradiation. This PhSe radical was then converted into PhSe + + by the SET catalyst Cu(OAc) 2 ·H 2 Ow hich reactedw ith MCPs to produce the phenylselenylcyclobutenes 76 [Eq.…”