Glycerin and CeCl₃ · 7H₂O: A New and Efficient Recyclable Reaction Medium for the Synthesis of Quinoxalines

FeCl3Mediated Simple, Green, and Efficient Method for the One-Pot Synthesis of Pyrazine-based Polycyclic Aromatic Compounds under Mild Conditions

“…Comparison of our results with some previously reported data for the synthesis of compound 3a(32)(33)(34)(35) …”

“…Then the reaction mixture was cooled to room temperature and filtered. The residue was purified by crystallization in ethanol or column chromatography on silica gel (ethylacetate/n-hexane (1:4)) (30)(31)(32)(33)(34)(35).…”

Bio-based solvents: an emerging generation of fluids for the design of eco-efficient processes in catalysis and organic chemistry

“…29 An efficient and environmentally benign process for the synthesis of quinoxalines 7 from diketones and 1,2-phenylenediamines has been developed using glycerol as a medium in the presence of cerium chloride as a catalyst (Scheme 2). 30 In this condensation, the reaction medium as well as the catalyst could be recycled without appreciable loss of its activity. Condensation of a-bromoketones and thiourea or thioamide compounds could also be performed in glycerol, affording the corresponding substituted thiazole derivatives in excellent yields.…”

Glycerol as Suitable Solvent for the Synthesis of Metallic Species and Catalysis

“…Lanthanide metals, in particular Ce III salts, have proven their ability as Lewis acid catalysts in glycerol for the synthesis of N‐containing heterocycles, such as bis(indoles),40 dihydropyridines,41 and quinoxalines,42 which exhibit a large range of biological activities.…”