Glycemic control, oxidative stress, and lipid profile in children with type 1 diabetes mellitus

Erciyas, Füsun; Taneli, Fatma; Arslan, Banu; Uslu, Yasemin

doi:10.1016/j.arcmed.2003.10.002

Cited by 81 publications

(71 citation statements)

References 25 publications

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“…Administration of BMBE in diabetic rats resulted in decreased levels of glycosylated hemoglobin showing its hypoglycemic effect. Glycosylated hemoglobin level was noted as showing positive correlation with total cholesterol, LDL cholesterol, triglycerides, and VLDL-cholesterol in DM patients (Ercyias et al, 2004). Our study also showed a significant correlation between glycosylated hemoglobin and lipid profile.…”

Section: Experimental Groupsupporting

confidence: 67%

Ethanol extract ofButea monospermabark modulates dyslipidemia in streptozotocin-induced diabetic rats

Divya

Mini

2014

Pharmaceutical Biology

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Context: Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus (DM). The availability of multiple lipid-lowering drugs and supplements provides new opportunities for patients to regulate lipid levels. Objective: The present study was designed to evaluate the effect of Butea monosperma Lam. (Fabaceae) bark extract in diabetes-induced dyslipidemia. Materials and methods: A daily dose of B. monosperma bark extract (BMBE, 500 mg/kg body weight) was given orally to streptozotocin (STZ)-induced diabetic rats for 60 d. Several indices such as blood glucose, insulin, glycosylated hemoglobin, TC, TG, high-density lipoproteincholesterol (HDL-C), apo A1, apo B, activities of lipogenic enzymes in tissues, liver function tests, and histopathology of liver were analyzed to assess the modulation of STZ-induced diabetic dyslipidemia by B. monosperma bark. Results: BMBE significantly reduced blood glucose (40.79%) and increased plasma insulin (37.5%) levels in diabetic rats. Altered levels of serum lipids, lipoproteins, and activities of lipogenic enzymes in tissues were partially restored upon the administration of BMBE in diabetic rats. Liver function tests and histopathological examination revealed that consumption of BMBE at a dose of 500 mg/kg body weight had no toxic effects in experimental rats. Conclusion: The findings suggest that BMBE supplementation could ameliorate dyslipidemia in DM.

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Section: Experimental Groupsupporting

confidence: 67%

Ethanol extract ofButea monospermabark modulates dyslipidemia in streptozotocin-induced diabetic rats

Divya

Mini

2014

Pharmaceutical Biology

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“…However, it is not known whether the lipid profile (lipid concentrations and lipoprotein composition) in youth with type 1 diabetes is proatherogenic compared with that in healthy nondiabetic youth. Some data suggest that, in adults with diabetes, lipoprotein composition is more atherogenic (7) and is substantially influenced by glycemic control (8). The goals of this study were to compare the lipid and lipoprotein profile, as measured by total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, non-HDL cholesterol, the triglycerideto-HDL cholesterol ratio, apolipoprotein B (apoB), and LDL particle size and density in youth with and without type 1 diabetes, and to explore the role of glycemic control, as measured by A1C, on the hypothesized altered lipid profile in type 1 diabetic youth.…”

mentioning

confidence: 99%

Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes

et al. 2009

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OBJECTIVE -The purpose of this study was to compare the lipid profile and the prevalence of lipid abnormalities in youth with and without type 1 diabetes and explore the role of glycemic control on the hypothesized altered lipid profile in youth with type 1 diabetes.RESEARCH DESIGN AND METHODS -We conducted a cross-sectional analysis of 512 youth with type 1 diabetes (mean duration 4.22 years) and 188 healthy control subjects aged 10 -22 years in Colorado and South Carolina. SEARCH for Diabetes in Youth (SEARCH) participants with type 1 diabetes and healthy control subjects recruited from primary care offices in the same geographic regions were invited to attend a research visit. Fasting lipid profiles were compared between youth with type 1 diabetes (stratified according to categories of optimal [A1C Ͻ7.5%] and suboptimal [A1C Ն7.5%] glycemic control) and healthy nondiabetic youth, using multiple linear and logistic regression.RESULTS -Youth with type 1 diabetes and optimal A1C had lipid concentrations that were similar (total cholesterol, LDL cholesterol, and LDL particle size) or even less atherogenic (HDL cholesterol, non-HDL cholesterol, triglyceride, and triglyceride-to-HDL cholesterol ratio) than those observed in nondiabetic youth, whereas youth with suboptimal glycemic control had elevated standard lipid levels (total cholesterol, LDL cholesterol, and non-HDL cholesterol). Youth with type 1 diabetes also had significantly elevated apolipoprotein B levels and more small, dense LDL particles than nondiabetic youth, regardless of glycemic control.CONCLUSIONS -Youth with type 1 diabetes have abnormal lipid levels and atherogenic changes in lipoprotein composition, even after a relatively short disease duration. As in adults, glycemic control is an important mediator of these abnormalities.

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“…attempts to employ markers of oxidative stress as additional clinical manifestations to evaluate the metabolic status in diabetes or to predict the risk of developing late complications have been undertaken by numerous authors [4][5][6][7].…”

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confidence: 99%

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

Salmonowicz¹,

Krzystek−Korpacka²,

Noczyńska³

2014

Adv Clin Exp Med

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Background. Magnesium (Mg), selinium (Se), zinc (Zn), manganese (Mn), and copper (cu) are involved in the mechanisms of antioxidant defense. Mn and cu, which participate in the generation of reactive oxygen species (ROS), also have pro-oxidative properties. Objectives. To evaluate the levels of Mg, Se, Zn, Mn, and cu, as well as the effectiveness of antioxidant defense mechanisms in children with Type 1Diabetes Mellitus (T1DM) and in their siblings. The preliminary findings were originally reported in 2009 at the 35 th annual conference of the International Society for Pediatric and adolescent Diabetes (ISPaD) in Ljubljana, Slovenia. Material and Methods. The study involved 87 children with T1DM, 2-19 years old, treated for T1DM for an average of 3.5 years. The sibling and control groups comprised 27 and 41 children, aged 4.5-16.5 years and 10.5-18 years respectively. The parameters named above were assessed in relation to metabolic compensation levels (Hb a1c ) and disease duration. Results. compared with the control group, T1DM children had lower plasma levels of Mg and Zn and higher levels of cu; the siblings had lower levels of Zn; T1DM children had lower copper/zinc superoxide dismutase (cuZnSOD) activity; and both T1DM children and their siblings had higher catalase (caT) activity and lower total antioxidant status (TaS) levels. Conclusions. There may be a correlation between impaired antioxidant status and Mg and Zn deficiency and increased cu levels in T1DM children. Oxidative stress in T1DM is accompanied by alterations in enzymatic activity and non-enzymatic mechanisms of antioxidant defense. The decreased TaS levels noted in T1DM patients may impair the effectiveness of non-enzymatic antioxidant systems. The increased caT activity and unimpaired selenium-dependent glutathione peroxidase (Se-GSHPx) activity point indirectly to enhanced ROS generation in T1DM children. The impaired antioxidant defense found in the siblings of T1DM patients may indicate that genetic factors play a role (Adv Clin Exp Med 2014, 23, 2, 259-268).

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Glycemic control, oxidative stress, and lipid profile in children with type 1 diabetes mellitus

Cited by 81 publications

References 25 publications

Ethanol extract ofButea monospermabark modulates dyslipidemia in streptozotocin-induced diabetic rats

Ethanol extract ofButea monospermabark modulates dyslipidemia in streptozotocin-induced diabetic rats

Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes

Trace Elements, Magnesium, and the Efficacy of Antioxidant Systems in Children with Type 1 Diabetes Mellitus and in Their Siblings

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