Glycemia and Memory

Welcome, M. Osain; Переверзев, В. А.

doi:10.5772/58241

Cited by 3 publications

(1 citation statement)

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“…Since sweet taste receptor heterodimer, T1R2+T1R3, is a novel glucosensor in the hypothalamus, further research in unraveling the signaling mechanisms associated with this receptor and other glucosensors in key brain areas is necessary to further understanding the association between glucosensors (including their relationship to metabolism) and cognitive functioning. In line with our earlier model of glucose memory facilitation [ 50 , 61 , 154 ], investigation into the mechanisms of neuroastroglial metabolic cooperativity in light of recent discoveries about sweet taste signaling is without doubt necessary.…”

Section: Future Directionmentioning

confidence: 64%

Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning

Welcome¹,

Mastorakis

Переверзев

2015

Neurology Research International

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Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning.

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Section: Future Directionmentioning

confidence: 64%