Glycated apolipoprotein B decreases after bariatric surgery in people with and without diabetes: A potential contribution to reduction in cardiovascular risk

Iqbal, Zohaib; Bashir, Bilal; Adam, Safwaan; Ho, Jan Hoong; Dhage, Shaishav; Azmi, Shazli; Ferdousi, Maryam; Yusuf, Zahid; Donn, Rachelle; Malik, Rayaz A.; Syed, Akheel A.; Ammori, Basil J.; Heald, Adrian; Durrington, Paul N.; Soran, Handrean

doi:10.1016/j.atherosclerosis.2022.01.005

Cited by 7 publications

(10 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The abundance of sd-LDL in metabolic syndrome and preferential nonenzymatic modifications of their ApoB moiety make them a suitable therapeutic target for metabolic surgery. We have reported significant reduction in sd-LDL and glycated ApoB along with triglycerides and an increase in HDL-C after bariatric surgery along with improvement in insulin resistance, glycaemia and markers of systemic inflammation [57 ▪ ,96]. Change in triglyceride concentration was positively correlated with change in insulin resistance and glycaemia [53,57 ▪ ].…”

Section: The Impact Of Bariatric Surgery On Cardiovascular Risk Factorsmentioning

confidence: 88%

“…We have reported significant reduction in sd-LDL and glycated ApoB along with triglycerides and an increase in HDL-C after bariatric surgery along with improvement in insulin resistance, glycaemia and markers of systemic inflammation [57 ▪ ,96]. Change in triglyceride concentration was positively correlated with change in insulin resistance and glycaemia [53,57 ▪ ]. Improvement in the atherogenic profile of LDL particles has been shown to be independent of weight loss but related to reduction in triglyceride concentration [123].…”

Section: The Impact Of Bariatric Surgery On Cardiovascular Risk Factorsmentioning

confidence: 88%

“…These irreversibly modified particles interact preferentially with scavenger receptors and receptors for AGE (RAGE) on macrophages and endothelial cells triggering a common downstream pathway of oxidative stress and inflammation culminating in endothelial dysfunction [56]. Glycation of ApoB is not a purely glycaemia-dependent process, as individuals with hyperinsulinaemia without established Type 2 diabetes (T2D) have been shown to have glyc-ApoB concentration comparable to individuals with T2D [57 ▪ ]. In addition, sd-LDL particles are more susceptible to glycation [52] and lowering apoB and LDL-C with statin treatment lowers glycated apoB significantly without changes in glycaemic parameters [58].…”

Section: Novel Cardiovascular Risk Factors and Metabolic Syndromementioning

confidence: 99%

See 2 more Smart Citations

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

Bashir,

Adam,

et al. 2023

Current Opinion in Lipidology

Self Cite

View full text Add to dashboard Cite

Purpose of review The aim of this study was to provide an overview of the role of novel biomarkers in metabolic syndrome, their association with cardiovascular risk and the impact of bariatric surgery on these biomarkers. Recent findings Metabolic syndrome encompasses an intricate network of health problems, and its constituents extend beyond the components of its operational definition. Obesity-related dyslipidaemia not only leads to quantitative changes in lipoprotein concentration but also alteration in qualitative composition of various lipoprotein subfractions, including HDL particles, rendering them proatherogenic. This is compounded by the concurrent existence of obstructive sleep apnoea (OSA) and nonalcoholic fatty liver disease (NAFLD), which pave the common pathway to inflammation and oxidative stress culminating in heightened atherosclerotic cardiovascular disease (ASCVD) risk. Bariatric surgery is an exceptional modality to reverse both conventional and less recognised aspects of metabolic syndrome. It reduces the burden of atherosclerosis by ameliorating the impact of obesity and its related complications (OSA, NAFLD) on quantitative and qualitative composition of lipoproteins, ultimately improving endothelial function and cardiovascular morbidity and mortality. Summary Several novel biomarkers, which are not traditionally considered as components of metabolic syndrome play a crucial role in determining ASCVD risk in metabolic syndrome. Due to their independent association with ASCVD, it is imperative that these are addressed. Bariatric surgery is a widely recognized intervention to improve the conventional risk factors associated with metabolic syndrome; however, it also serves as an effective treatment to optimize novel biomarkers.

show abstract

Section: The Impact Of Bariatric Surgery On Cardiovascular Risk Factorsmentioning

confidence: 88%

Section: The Impact Of Bariatric Surgery On Cardiovascular Risk Factorsmentioning

confidence: 88%

Section: Novel Cardiovascular Risk Factors and Metabolic Syndromementioning

confidence: 99%

See 1 more Smart Citation

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

Bashir,

Adam,

et al. 2023

Current Opinion in Lipidology

Self Cite

View full text Add to dashboard Cite

show abstract

“…As mentioned in the introduction, several earlier investigations indicated that BS has beneficial health effects. For example, it was found that it affects the artherogenic properties of plasma lipoprotein [ 47 ] and reduces cardiovascular risks [ 48 ]. Furthermore, several studies showed that it normalizes the metabolism of amino acids and proteins [ 49 ] as well as the levels of systemic hormones and signaling peptides [ 50 , 51 , 52 , 53 , 54 ] and improves glycemic control [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Bariatric Surgery on the Stability of the Genetic Material, Oxidation, and Repair of DNA and Telomere Lengths

et al. 2023

View full text Add to dashboard Cite

Obesity causes genetic instability, which plays a key-role in the etiology of cancer and aging. We investigated the impact of bariatric surgery (BS) on DNA repair, oxidative DNA damage, telomere lengths, alterations of antioxidant enzymes and, selected proteins which reflect inflammation. The study was realized with BS patients (n = 35). DNA damage, base oxidation, BER, and NER were measured before and 1 month and 6 months after surgery with the single-cell gel electrophoresis technique. SOD and GPx were quantified spectrophotometrically, malondealdehyde (MDA) was quantified by HPLC. Telomere lengths were determined with qPCR, and plasma proteome profiling was performed with high-resolution mass spectrophotometry. Six months after the operations, reduction of body weight by 27.5% was observed. DNA damage decreased after this period, this effect was paralleled by reduced formation of oxidized DNA bases, a decline in the MDA levels and of BER and NER, and an increase in the telomere lengths. The activities of antioxidant enzymes were not altered. Clear downregulation of certain proteins (CRP, SAA1) which reflect inflammation and cancer risks was observed. Our findings show that BS causes reduced oxidative damage of DNA bases, possibly as a consequence of reduction of inflammation and lipid peroxidation, and indicate that the surgery has beneficial long-term health effects.

show abstract

“…Bearing in mind the findings that decreased dietary AGEs are associated with lower levels of glycated LDLs in the plasma of patients with DM [ 91 ], as well as that energy-restricted weight loss is associated with reduced plasma AGEs levels [ 92 ], the importance of nutritional and lifestyle changes should not be neglected. More recently, a beneficial effect of bariatric surgery on the level of glycated apoB was reported during the follow-up of obese patients with and without type 2 DM [ 93 ].…”

Section: Implications For Cardiovascular Prevention and Future Direct...mentioning

confidence: 99%

The Role of Advanced Glycation End Products on Dyslipidemia

et al. 2023

View full text Add to dashboard Cite

Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs’ production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.

show abstract

Glycated apolipoprotein B decreases after bariatric surgery in people with and without diabetes: A potential contribution to reduction in cardiovascular risk

Cited by 7 publications

References 46 publications

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

Established and potential cardiovascular risk factors in metabolic syndrome: Effect of bariatric surgery

Impact of Bariatric Surgery on the Stability of the Genetic Material, Oxidation, and Repair of DNA and Telomere Lengths

The Role of Advanced Glycation End Products on Dyslipidemia

Contact Info

Product

Resources

About