Glycated albumin is independently associated with estimated glomerular filtration rate in nondiabetic patients with chronic kidney disease

Beyond HbA1c and Glucose: the Role of Nontraditional Glycemic Markers in Diabetes Diagnosis, Prognosis, and Management

“…65,93–100 Nonetheless, despite their associations with clinical outcomes, fructosamine and glycated albumin may also be limited in this setting, since proteinuria and altered serum protein turnover may affect interpretation of these tests. 101–103 …”

Effects of incretin agonists on endothelial nitric oxide synthase expression and nitric oxide synthesis in human coronary artery endothelial cells exposed to TNFα and glycated albumin

“…Serum levels of glycated albumin are better correlated with severity of cardiovascular disease and were also found to be a better indicator of glycemic fluctuations than glycated hemoglobin HbA1c [11]. In patients with uncontrolled diabetes, the level of glycated albumin exceeds 16% of the total albumin and could be as high as 8.2 g/l in subjects with stage IV chronic kidney disease [12,13]. A 2006 study found that serum glycated albumin levels were significantly increased in diabetic patients with CAD and exceed 20% of total albumin [14].…”

Serum carbohydrate antigen 153 and renal function in patients with type 2 diabetes mellitus

“…The relationship between glycosylation and progression of chronic kidney disease has been established in T2DM , and a higher percentage of glycosylation may result in renal function impairment in both diabetic and nondiabetic subjects . Unfortunately, systemic inflammation and hyperglycemia may alter MUC1 gene expression in patients with T2DM. First, the expression of MUC1 gene is regulated by several cytokines including TNF, and MUC1 gene is related to the transcription of inflammatory cytokines by NF‐kB signaling pathway .…”