Serum carbohydrate antigen 153 and renal function in patients with type 2 diabetes mellitus

Peng, You‐Fan; Lin, Hao; Han, Manman; Li, Ling

doi:10.1002/jcla.22461

Cited by 5 publications

(6 citation statements)

References 33 publications

(33 reference statements)

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“…showed that any degree of albuminuria is a risk factor for cardiovascular events in individuals with T2DM and that risk increases progressively with UACR elevation ( 8 ). A previous study found that CA153 was negatively related to eGFR and positively related to HbA 1c and FPG in patients with T2DM ( 9 ). Turgutalp et al.…”

Section: Discussionmentioning

confidence: 94%

“…A previous study indicated that CA199 levels in T2DM patients with microvascular complications including neuropathy, diabetic nephropathy, and retinopathy were significantly increased in comparison with those without microvascular complications ( 13 ). It has also been reported that renal impairment could lead to increased serum CA125 levels, which have been independently correlated with urinary microalbumin ( 14 ). Our results are in agreement with this finding.…”

Section: Discussionmentioning

confidence: 99%

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Changes in serum tumor markers in type 2 diabetes mellitus with microalbuminuria

Chen,

Du,

et al. 2023

Front. Endocrinol.

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ObjectivesThe objective of this study was to investigate changes in serum tumor markers in type 2 diabetes mellitus (T2DM) with microalbuminuria and analyze the relationship between tumor markers and microalbuminuria.MethodsA total of 956 T2DM patients aged 40–70 years hospitalized in the Department of Endocrinology, Xinhua Hospital, China, affiliated with Shanghai Jiaotong University School of Medicine, were enrolled from January 2018 to December 2020. The sample comprised 313 T2DM patients with microalbuminuria and 643 T2DM patients with normal urinary microalbumin levels. After assessing the changes in serum tumor markers in T2DM with microalbuminuria, we analyzed the risk of microalbuminuria by the serum tumor marker category using multiple logistic regression analysis.ResultsSerum CEA, CA199, CA125, CA153, CA211, SCC, CA242, and CA50 levels were significantly higher in T2DM patients with microalbuminuria than in those without microalbuminuria, while serum AFP levels were lower in the microalbuminuria group (P < 0.05). Following adjustment of confounders, serum CEA, CA211, and SCC were independently associated with microalbuminuria in T2DM. An ROC curve was used to estimate the cutoff point of tumor markers for microalbuminuria. Taking the values under the cutoff points as a reference, values for CEA, CA211, and SCC above the cutoff points indicated a significantly high risk of microalbuminuria. The OR of increased CEA for microalbuminuria was 2.006 (95%CI 1.456–2.765), the OR of increased CA211 for microalbuminuria was 1.505 (95%CI 1.092–2.074), and the OR of increased SCC for microalbuminuria was 1.958 (95%CI 1.407–2.724).ConclusionSeveral serum tumor markers were related to microalbuminuria in T2DM. Serum tumor markers such as CEA, SCC, and CA211 may indicate early diabetic nephropathy, particularly when elevated in combination.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Changes in serum tumor markers in type 2 diabetes mellitus with microalbuminuria

Chen,

Du,

et al. 2023

Front. Endocrinol.

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“…The median, interquartile range (IQR) of RFM in females was higher than that in males (44.8 (42.3-47.2) % vs 31.3 (28.8-34.1) %, respectively; P < .0001). The median (IQR) of BMI in females was no higher than that in males (30 (27-34) kg/m 2 vs 30 (27)(28)(29)(30)(31)(32)(33)(34), respectively; P = .5152). The obesity prevalence was 99% in males and 98% in females according to RFM.…”

Section: Re Sultsmentioning

confidence: 85%

“…33 Peng et al demonstrated that serum carbohydrate antigen 153 negatively correlates with renal function in T2DM patients. 34 We did not include these laboratory tests in our study. The limitations of this study are the absence of the reference methods for the determination of body fat percentage and GFR.…”

Section: Ta B L Ementioning

confidence: 99%

The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients

Skalický

Adamíková

Ponížil

2020

Clinical Laboratory Analysis

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Type 2 diabetes mellitus (T2DM) is associated with compromised health-related quality of life 1 and premature death from vascular disease and several types of cancers. 2 Insulin resistance is the earliest feature in the development of T2DM. Insulin resistance is induced by obesity, inflammation, 3 and low physical activity. 4 Conversely, physical activity accompanied by weight loss leads to improvement in insulin sensitivity. 5

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“…The expression of CEA correlates with age [ 26 ], smoking [ 27 ], glucose and lipid metabolism disorders [ 28 , 29 ], and the chronic inflammatory state of the body [ 30 ]. However, CA153 was also significantly increased in diseases such as renal impairment in type 2 diabetes [ 31 ], interstitial lung disease [ 32 ], idiopathic inflammatory myositis [ 33 ], sarcoidosis [ 34 ], and SARS-CoV-2 infection [ 35 ]. Adjuvant chemotherapy can aggravate blood glucose and blood lipid metabolic disorders while killing potential tumors [ 36 , 37 ], leaving the body in a state of chronic inflammation.…”

Section: Discussionmentioning

confidence: 99%

Changes of Tumor Markers in Patients with Breast Cancer during Postoperative Adjuvant Chemotherapy

et al. 2022

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Objective. Serum tumor marker (STM) elevation can detect metastasis earlier than imaging diagnosis and, although not recommended by guidelines, is still widely used in clinical practice for postoperative follow-up of breast cancer patients. The purpose of this study was to investigate the change rules of CEA and CA153 in patients with HER2-negative breast cancer during postoperative adjuvant chemotherapy and their influencing factors. Materials and Methods. The medical records of patients with HER2-negative early breast cancer who visited Xuanwu Hospital from September 2018 to June 2021 were retrospectively analyzed. Demographic characteristics and baseline data of CEA and CA153 at initial diagnosis were collected. Data of CEA, CA153, biochemistry (including ALT, AST, rGT, triglycerides, cholesterol, and blood glucose) and blood routine (including white blood cells, neutrophils, monocytes, lymphocytes, and platelets) were also collected before chemotherapy, at the end of chemotherapy and more than 3 months after the end of chemotherapy. LY/MONO, NEUT/LY, PLT/LY, and systemic immune inflammation index (SII) were calculated and statistically analyzed using SPSSAU software. Results. A total of 90 patients were enrolled, all of whom were female, with a mean age of 55.11 ± 10.60 y. The value of CEA at initial diagnosis was 2.10 ± 1.11 ng/mL, and high expression was mostly correlated with past history of chronic diseases and tumor lymph node metastasis; the value of CA153 was 11.80 ± 6.60 U/mL, and high expression was correlated with high SII at initial diagnosis. Surgery did not affect the values of serum CEA and CA153. At the end of chemotherapy, CEA and CA153 were 2.68 ± 1.34 ng/mL and 18.51 ± 8.50 U/mL, respectively, which were significantly increased compared with those before chemotherapy, and were linearly correlated with the values before chemotherapy. They decreased (CEA 2.45 ± 1.19 ng/mL, CA153 10.87 ± 5.96 U/mL) again three months after the end of chemotherapy, manifested as “spiking” phenomenon, which was associated with lymph node metastasis at diagnosis, body metabolic disorders, and chronic inflammatory status. Conclusion. CEA and CA153 were increased presenting as “spiking” phenomena in patients with early HER2-negative breast cancer during postoperative adjuvant chemotherapy, and the peak of increase was linearly correlated with the indicators before chemotherapy. Clinical attention should be paid to this change to avoid excessive diagnosis and treatment leading to medical resource consumption.

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Serum carbohydrate antigen 153 and renal function in patients with type 2 diabetes mellitus

Abstract: Serum CA153 is negatively correlated with estimated GFR in patients with T2DM, and serum CA153 may be a potentially useful clinical biomarker to assess renal function in the study population.

Cited by 5 publications

References 33 publications

Changes in serum tumor markers in type 2 diabetes mellitus with microalbuminuria

Changes in serum tumor markers in type 2 diabetes mellitus with microalbuminuria

The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients

Changes of Tumor Markers in Patients with Breast Cancer during Postoperative Adjuvant Chemotherapy

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