2017
DOI: 10.1016/j.jip.2016.11.008
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Glycan region of GPI anchored-protein is required for cytocidal oligomerization of an anticancer parasporin-2, Cry46Aa1 protein, from Bacillus thuringiensis strain A1547

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Cited by 10 publications
(11 citation statements)
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“…subsequently forms a membrane embedded oligomer that forms pore and induces permeability of the plasma membrane leading to cell death (Abe et al, 2017). Other PS proteins also kill cells by pore formation.…”
Section: Bacillus Thuringiensismentioning
confidence: 99%
See 1 more Smart Citation
“…subsequently forms a membrane embedded oligomer that forms pore and induces permeability of the plasma membrane leading to cell death (Abe et al, 2017). Other PS proteins also kill cells by pore formation.…”
Section: Bacillus Thuringiensismentioning
confidence: 99%
“…Inhibit tumor growth, cell cycle arrest, apoptosis and metastasis arrest (Wu et al, 2017) Levan Increase oxidative stress and apoptosis (Queiroz et al, 2017) L-asparaginase Causes nutritional de ciencies and inhibit protein synthesis resulting in apoptosis (Shrivastava et al, 2016) Ieodoglucomide B Inhibit tumor cell growth (Tareq et al, 2013) Bacillistatins 1 and 2 Inhibit tumor cell growth (Pettit, Arce, Chapuis, & Macdonald, 2015) Mixirins A, B and C Inhibit tumor cell growth (Harris & Pierpoint, 2012) Parasporin 1 Activates apoptotic signaling pathway by binding with Beclin 1 receptor and increase Ca 2+ in ux (Katayama et al, 2007) Parasporin 2 Permeabilize plasma membrane through GPIanchored protein (Abe et al, 2017) Parasporin 3 Pore formation (Ito et al, 2004) Parasporin 4 Cholesterol independent pore formation (Yamashita et al, 2005) Parasporin 6 Swelling of cells and vacuoles formation…”
Section: Surfactinmentioning
confidence: 99%
“…Oligomerization has been studied in several wild type and mutant toxins such as Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ca, Cry1Da, Cry1Ea, Cry1Fa, Cry2Ab, Cry3Aa, Cry3Ba, Cry3Ca, Cry4Ba, Cry11Aa and Cry46Aa1 [15,[17][18][19][20][21][22][23][24][25]. Oligomerization has also been detected in other Bt toxins such as Cyt [26] and Vip [27].…”
Section: Introductionmentioning
confidence: 99%
“…In 2009, Akiba et al [134] proposed that PS2 toxins were able to produce oligomers that induce membrane pores and cell death by bind to lipid rafts. In 2017, Abe et al reported that GPI was an essential co-receptor to PS2 parasporins toxic activity [135]. The action mechanism of PS2 family members is apparent by activating apoptosis, which is associated to an increase in the tumor suppressor gene PAR-4 expression and through inhibition of the PI3K/AKT pathway [136].…”
Section: Ps2 Familymentioning
confidence: 99%