Gluten Content of the Top 200 Medications: Follow-Up to the Influence of Gluten on a Patient's Medication Choices

King, Allison R.

doi:10.1310/hpj4809-736

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…However, since excipients and manufacturing processes can change over time, their advice was that it is essential to check on demand with the manufacturer regarding each specific product. The list was updated by the original authors in November 2009 [ 13 ] and July 2012 [ 14 ], including the gluten content of the top 200 medications in the US, sorted by retail sales and total number of prescriptions. The authors also included an updated list of manufacturers that claimed to be gluten-free in March 2010 [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…Databases with gluten content are intended to help prescribers make informed decisions. However, it is recommended that they be continuously updated by directly contacting the manufacturer, since raw materials or some formulation procedures could be different from those used when the data was originally collected [ 11 – 14 , 16 ] and because, although many manufacturers believed that their products were devoid of gluten, they did not certify or test the gluten-free status in the final products [ 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Gluten in pharmaceutical products: a scoping review

2021

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Background Celiac disease (CD) is one of the most common gluten-related disorders. Although the only effective treatment is a strict gluten-free diet, doubts remain as to whether healthcare professionals take this restriction into consideration when prescribing and dispensing medicines to susceptible patients. This scoping review aimed to find out the current evidence for initiatives that either describe the gluten content of medicines or intend to raise awareness about the risk of prescribing and dispensing gluten-containing medicines in patients with CD and other gluten-related disorders. Methods A scoping review was conducted using three search strategies in PubMed/MEDLINE, TripDatabase and Web of Science in April 2021, following the PRISMA extension for scoping reviews (PRISMA-ScR). References from included articles were also examined. Two researchers screened the articles and results were classified according to their main characteristics and outcomes, which were grouped according to the PCC (Population, Concept and Context) framework. The initiatives described were classified into three targeted processes related to gluten-containing medicines: prescription, dispensation and both prescription and dispensation. Results We identified a total of 3146 records. After the elimination of duplicates, 3062 articles remained and ultimately 13 full texts were included in the narrative synthesis. Most studies were conducted in the US, followed by Canada and Australia, which each published one article. Most strategies were focused on increasing health professional’s knowledge of gluten-containing/gluten-free medications (n = 8), which were basically based on database development from manufacturer data. A wide variability between countries on provided information and labelling of gluten-containing medicines was found. Conclusion Initiatives regarding the presence of gluten in medicines, including, among others, support for prescribers, the definition of the role of pharmacists, and patients’ adherence problems due to incomplete labelling of the medicines, have been continuously developed and adapted to the different needs of patients. However, information is still scarce, and some aspects have not yet been considered, such as effectiveness for the practical use of solutions to support healthcare professionals.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gluten in pharmaceutical products: a scoping review

2021

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“…Inactive ingredients produced from wheat starch can result in gluten content in medications. In a survey (28), 18% of manufacturers indicated that their medications contain gluten. Although 69% claimed to produce gluten-free products, only 17% tested their products and could provide documentation on the performed tests.…”

Section: Lactose Peanut Oil Gluten and Chemical Dyesmentioning

confidence: 99%

“Inactive” ingredients in oral medications

et al. 2019

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Oral forms of medications contain “inactive” ingredients to enhance their physical properties. Using data analytics, we characterized the abundance and complexity of inactive ingredients in approved medications. A majority of medications contain ingredients that could cause adverse reactions, underscoring the need to maximize the tolerability and safety of medications and their inactive ingredients.

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“…Food is not the only source of gluten protein. Some commonly prescribed medications (e.g., amoxicillin, azithromycin, cephalexin, levothyroxine, metformin, prednisone, albuterol, and extended-release methylphenidate) also contain gluten within their inactive ingredients such as starches (King, 2013).…”

Section: Treatmentmentioning

confidence: 99%

Celiac Disease in the Pediatric Population

Durham¹,

Temples²

2018

Journal of Pediatric Health Care

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Celiac disease is an autoimmune disorder in which the lining of the gastrointestinal tract is damaged by an immunemediated response to gluten proteins (Allen, 2015). It is a polygenetic disease that only appears in genetically susceptible individuals (Newton & Singer, 2012). It is a worldwide concern, with North America having a high prevalence rate (Liu et al., 2017). Celiac disease can present in a spectrum of manifestations, making it difficult to identify and diagnosis (Reilly & Green, 2012). High-risk populations include those with a positive family history as well as individuals with other autoimmune disorders (Newton & Singer, 2012). Screening and diagnosis are completed with a blood test followed by a biopsy of the small intestinal lining (Zevit & Shamir, 2014). Currently, the only treatment for celiac disease is a strict, gluten-free diet. Further research is warranted in areas of environmental risk factors and treatments (

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Gluten Content of the Top 200 Medications: Follow-Up to the Influence of Gluten on a Patient's Medication Choices

Cited by 8 publications

References 5 publications

Gluten in pharmaceutical products: a scoping review

Gluten in pharmaceutical products: a scoping review

“Inactive” ingredients in oral medications

Celiac Disease in the Pediatric Population

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